Infection-Associated Cancer Research Training Program in Mali

马里感染相关癌症研究培训计划

• 批准号: 10223788
• 负责人: Lifang Hou
• 金额: $ 26.37万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223788
• 关键词: Address; Africa; Africa South of the Sahara; Bioinformatics; Biological Markers; Biometry; Clinical Management; Collaborations; Collection; Data; Detection; Diagnostic; Discipline; Doctor of Philosophy; Educational workshop; Epidemiologist; Epidemiology; Faculty; Funding; Goals; Health system; Individual; Infection; Interdisciplinary Study; Knowledge; Laboratories; Mali; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of liver; Malignant neoplasm of lung; Mentors; Microscopic; Modality; Molecular; Morbidity - disease rate; National Cancer Institute; Outcome; Pathologist; Population; Population Study; Populations at Risk; Prevention; Protocols documentation; Public Health; Research Personnel; Research Priority; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Science; Scientist; Screening procedure; Source; Specimen; Techniques; Technology; Telepathology; Training; Training Programs; Training and Education; Treatment outcome; United States National Institutes of Health; Universities; anticancer research; biomarker development; cancer epidemiology; design; early-career faculty; epidemiology study; experience; global health; improved; malignant stomach neoplasm; mortality; novel; population based; programs; risk stratification; screening; skills; specific biomarkers; tool; virtual

PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research Training Program addresses a National Cancer Institute (NCI) high research priority and a significant and growing source of morbidity and mortality in sub-Saharan Africa, particularly in Mali. In 2018, the four most common infection-associated cancers (IACs; cervical, liver, gastric and lung cancers) represented more than a quarter (27%) of all registered cancers in Mali. The NM-IAC Program seeks to build an interdisciplinary, collaborative, research training program to train researchers in the conduct of population-based cancer epidemiology and molecular studies and advance the discovery of unique population-specific risk factors and biomarkers for the development of risk stratification and screening tools of individuals with underlying infections at increased risk of associated cancers, with the ultimate goal of improving detection, treatment, and outcomes. The NM-IAC Program will leverage our team’s extensive experience in conducting NIH-funded global health research training programs in Africa, program refinements, and highly successful training resources and outcomes from our decade-long, research-training collaboration between USTTB and NU. Our central hypothesis is that building capacity in the key disciplines involved in IACs will empower Malian and US investigators to develop and implement novel, contextually appropriate, and culturally adapted risk stratification and screening tools. To achieve our goals, our specific aims are to (1) Train two (2) PhD-level cancer epidemiologists, each with a focus on one of the four IACs and capable of (i) designing and conducting population-based cancer epidemiology studies; (ii) developing protocols for biospecimen collection, processing, and storage; and (iii) evaluating population-specific biomarkers for use in screening and identifying “at-risk” populations; and Two master’s-level molecular pathologists, one biostatistician, and one bio-informatician, capable of (i) collecting and managing clinical, laboratory, and population-level specimens and data; (ii) using virtual modalities for training, education, and mentoring and telepathology for distance microscopic diagnostics and training; and (iii) performing comprehensive biostatistical and bioinformatics analyses, generated from population-level studies; (2) Enhance the knowledge and skills of existing faculty, particularly early career faculty, to contribute to and participate in interdisciplinary research teams of mechanistic and population-based studies of IACs through medium-term intensive workshops and mentored research projects led by the scientists trained in Aim 1; and (3) Optimize engagement of public health scientists, clinicians, and health system stakeholders through workshops and seminars to disseminate knowledge about the novel epidemiological and biomarker tools and strategies, for use in new programs focused on the prevention and detection of IACs in Mali.

项目摘要 西北大学（NU）和马里科学大学和技术 Bamako（USTTB）的感染相关癌症（NM-IAC）研究培训计划解决了一个国家 癌症研究所（NCI）的高度研究优先级，以及在病态和死亡率的重要来源 撒哈拉以南非洲，特别是在2018年的马里。 宫颈，肝，胃癌和肺癌）代表所有注册癌症的四分之一以上（27％） 马里。 研究人员从事基于人群的癌症流行病学和分子研究并推进了您 发现独特的特定特定风险因素和生物标志物，以开发风险分层和 筛查具有潜在感染的个体的工具，与您相关的癌症风险增加了 改善检测，治疗和结果的最终目标。 在非洲进行NIH资助的全球健康研究培训计划方面的丰富经验 精炼以及非常成功的培训资源和我们十年的研究培训的成果 USTTB和NU之间的合作是我们的中心假设 参与IACS将使马里安和美国调查人员能够开发和实施小说 适当的和文化适应的风险分层和筛选工具。 目的是（1）训练两（2）个PHD级癌症的表演者，每个癌症的焦点是四个IACS之一 并且能够（i）设计和结合基于人群的癌症流行病学研究； 生物测量，处理和存储的协议； 用于筛选和识别“处于危险”的流行分子的生物标志物 病理学家，一位生物统计学家和一位生物 - 形式的人，能够（i）收集和管理临床， 实验室和人口级标本和数据； 距离微观诊断和培训的指导和远程病理学； 综合的生物阶级和生物信息学分析，是由人口级研究产生的（2）； 增强现有教师，尤其是早期职业教师的知识和技能，以贡献和 通过参加IAC的机械和人群研究的跨学科研究团队 在AIM 1中追踪的科学家领导的中期密集研讨会和指导研究项目； （3）优化公共卫生科学家，临床医生和卫生系统利益相关者的参与 讲习班和研讨会，以讨论有关唯一的流行病学和生物标志物工具的知识 策略，用于用于预防和发现马里IAC的新计划。