The MobileToolbox for Monitoring Cognitive Function - Data and Statistical Analysis Core

用于监测认知功能的 MobileToolbox - 数据和统计分析核心

基本信息

批准号：
10212851
负责人：
David Michael Condon
金额：
$ 17.82万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10212851
关键词：
Age Alzheimer&apos s Disease Assessment tool Calibration Censuses Clinical Cognition Computing Methodologies Data Data Aggregation Data Analyses Data Analytics Data Files Data Scientist Data Security Data Storage and Retrieval Databases Development Disease Education Engineering Ensure Ethics Ethnic Origin FAIR principles Funding General Population Genomics Goals Gold HIV-associated neurocognitive disorder Impaired cognition Impairment Information Systems Infrastructure International Libraries Maintenance Measurement Measures Metadata Monitor Parkinson Disease Participant Patient Outcomes Assessments Population Population Distributions Privacy Procedures Process Property Psychometrics Race Reproducibility Research Research Personnel Residencies Resources Rural Sampling Science Secure Sensitivity and Specificity Statistical Data Interpretation Structure Synapses System Technology Testing United States National Institutes of Health Validation Work analytical method base biological sex cloud based cognitive ability cognitive function cognitive testing computer science data interoperability data management data privacy data repository data sharing digital experience field study human very old age (85+)longitudinal design mHealth mild cognitive impairment novel

项目摘要

Data Core Summary The Data and Statistical Analysis Core (Data Core) will provide both the data management and analytic support needed to ensure the validity and reproducibility of MobileToolbox assessment tools. It will oversee the development, refinement and maintenance of the data management infrastructure needed to ensure data interoperability, data security and privacy (Aim 1). The data management infrastructure will include Sage Bionetworks’ existing Synapse platform. Synapse is a cloud-based data storage and organization system developed to facilitate sharing data, analysis and computational methods across distributed research teams. The Data Core will also serve as a central unit to direct, manage, and coordinate both psychometric and statistical analysis (Aim 2). The Data Core will manage and conduct the analyses needed for psychometric validation and norming of measures included in the MobileToolbox library. The Data Core will develop new normative values and conduct a multi-pronged validation analyses using several diverse samples. This work will be performed by the team of statisticians and psychometricians responsible for norming and validation of the NIH Toolbox, the Patient Reported Outcome Measurement Information System, and the International Cognitive Ability Resource. The Data Core will calibrate newly developed item banks and validate the MobileToolbox by conducting psychometric (item-level) and statistical (scale-level) analyses to determine psychometric properties, structural validity, construct validity, and longitudinal validity (both “burst” and traditional) of measures made available in the MobileToolbox Library. The Data Core will also conduct regression-based analyses in order to create normative values for MobileToolbox Cognition measures, including values corrected for relevant demographic variables such as age, education, race and ethnicity. Norms for change will also be created.

数据核心总结数据和统计分析核心（Data Core）将提供数据管理和分析确保 MobileToolbox 评估工具的有效性和可重复性所需的支持它将进行监督。确保数据所需的数据管理基础设施的开发、完善和维护互操作性、数据安全性和隐私（目标 1）。 Bionetworks 现有的 Synapse 平台是一个基于云的数据存储和组织系统。旨在促进分布式研究团队之间共享数据、分析和计算方法。数据核心还将作为一个中央单元来指导、管理和协调心理测量和统计分析（目标 2）。数据核心将管理和进行心理测量所需的分析。 MobileToolbox 库中包含的措施的验证和规范将开发新的。规范值并使用多个不同样本进行多管齐下的验证分析。将由负责规范和验证的统计学家和心理测量师团队执行 NIH 工具箱、患者报告结果测量信息系统和国际认知能力资源。数据核心将校准新开发的项目并验证银行。 MobileToolbox 通过进行心理测量（项目级）和统计（量表级）分析来确定心理测量特性、结构有效性、建构有效性和纵向有效性（“爆发”和“ MobileToolbox 库中提供的传统）措施也将进行。基于回归的分析，以便为 MobileToolbox 认知测量创建规范值，包括针对年龄、教育程度、种族和民族等相关人口变量进行校正的值。变革的规范也将被创建。