Antibody Profiles and Genetics of Pernio-Like Lesions during the COVID-19 pandemic

COVID-19 大流行期间冻疮样病变的抗体谱和遗传学

基本信息

批准号：
10212890
负责人：
Esther E Freeman
金额：
$ 5.39万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-07 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10212890
关键词：
2019-nCoV Acute Africa South of the Sahara Antibodies Antibody Response Area Biological COVID-19 COVID-19 patient Caring Cellular Immunity Cessation of life Chilblains Clinical Clinical Trials Collaborations Communities Complex Convalescence Cutaneous Databases Dermatologic Dermatology Development Disease Enrollment Family Future General Hospitals Genetic Genetic Determinism Genetic Polymorphism HIV Hand Hospitalization Immune response Individual Infection Inflammation Inflammatory Inflammatory Response Information Systems Infrastructure Institution International Intramural Research Investigation Kaposi Sarcoma Knowledge Laboratories Lesion Massachusetts Molecular Patients Phenotype Proteomics Protocols documentation Reporting Research Resources Role SARS-CoV-2 infection Sampling Serology Skin Specimen Symptoms Testing Therapeutic Time Toes United States National Institutes of Health Vaccines Viral Virus Virus Diseases acute infection adaptive immune response antibody detection asymptomatic COVID-19 clinical phenotype cohort coronavirus disease foot improved pandemic disease patient population patient response patient subsets recruit response sample collection skin disorder skin lesion

项目摘要

A subset of patients with coronavirus disease-2019 (COVID-19) develop cutaneous manifestations of their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, including pernio of their feet and hands, known as “COVID toes.” These patients tend to have a mild disease course, which may indicate successful viral control by the host. By leveraging an existing patient cohort at Massachusetts General Hospital (MGH), and the extensive laboratory infrastructure at the NIH, this proposal aims to elucidate the complex determinants of a unique phenotype of COVID-19: pernio/ “COVID toes,” with the following Aims. Aim 1: To evaluate genetic determinants of pernio-like lesions (“COVID toes”) in response to SARS-CoV-2 infection. Aim 2: To characterize the inflammatory and serological response during acute infection and convalescence of patients with SARS-CoV-2 who develop pernio-like lesions as a symptom of COVID-19. Biological samples will be obtained at MGH and sent to collaborating labs at the NIH. In particular, this proposal will help us understand the host immune response to COVID-19 by focusing on patients who have controlled the disease and have had relatively mild clinical courses, as characterized by their skin lesions. Successful completion of our aims will immediately and directly respond to important gaps in our knowledge regarding mild/asymptomatic COVID-19, which in turn can help inform our understanding of how to harness this type of successful control for other patients.

一部分 2019 冠状病毒病 (COVID-19) 患者会出现严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的皮肤表现，包括脚和手的冻疮，即所谓的“新冠脚趾”。患者的病程往往较轻，这可能表明宿主成功控制了病毒。通过利用马萨诸塞州总医院 (MGH) 现有的患者队列和 NIH 广泛的实验室基础设施，该提案旨在阐明复杂的决定因素。 COVID-19 的独特表型：pernio/“COVID 脚趾”，目标 1：评估针对 SARS-CoV-2 感染的 pernio 样病变（“COVID 脚趾”）的遗传决定因素。 2：为了表征出现冻疮样病变作为 COVID-19 症状的 SARS-CoV-2 患者在急性感染和恢复期期间的炎症和血清学反应。特别是，该提案将重点关注已控制疾病且临床病程相对较轻（以皮肤病变为特征）的患者，从而帮助我们了解宿主对 COVID-19 的免疫反应。成功完成我们的目标将立即直接弥补我们在轻度/无症状 COVID-19 方面的知识差距，这反过来又可以帮助我们了解如何对其他患者进行这种成功的控制。