Infant Bronchiolitis and Viral Core (IBVC)
婴儿细支气管炎和病毒核心 (IBVC)
基本信息
- 批准号:10205988
- 负责人:
- 金额:$ 6.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-09-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:Accident and Emergency departmentAge-MonthsAllergensAsthmaBasic ScienceBiologicalBronchiolitisChildChild HealthClinicalClinical ResearchCommunicable DiseasesDataDevelopmentDiagnosticDiseaseDisease ProgressionEnrollmentEnsureEnvironmentEpigenetic ProcessEpithelialEquipmentExperimental DesignsFundingGoalsHomeHospitalsHumanHuman ResourcesHypersensitivityImmunityImmunoassayImmunologyImmunology procedureIndividualInfantInfectionInstitutesInterferonsLaboratoriesLower Respiratory Tract InfectionLower respiratory tract structureMeasurementMedicalMethodologyMethodsMorbidity - disease rateMucous MembraneNoseOutcomeOutpatientsPathogenesisPerformancePhysiciansPhysiologyPlayPneumoniaPreparationProceduresProductivityReagentRecurrenceReproducibilityResearchResearch PersonnelResearch Project GrantsResourcesRespiratory MucosaRespiratory Syncytial Virus InfectionsRespiratory Tract DiseasesRespiratory Tract InfectionsRespiratory syncytial virusRoleSamplingScientistServicesSeveritiesSeverity of illnessSignal TransductionStimulusSucroseTechnical ExpertiseTranslational ResearchUnited States National Institutes of HealthUpper Respiratory InfectionsViralViral Respiratory Tract InfectionVirusWheezingWorkairway inflammationairway remodelingbasecohortcostcost efficientcytokineexperiencemouse modelmultidisciplinaryoperationoxidative damagepediatric departmentperformance testsprogramsresponsesuccesssynergismsynthetic polymer Bioplextherapeutic developmentvaccine development
项目摘要
PROJECT SUMMARY/ABSTRACT
Respiratory syncytial virus (RSV) causes a spectrum of disease in children ranging from upper respiratory
infections to severe lower respiratory tract disease, such as bronchiolitis and pneumonia. Although the
determinants of disease progression from the upper to the lower respiratory tract, severity of bronchiolitis,
recurrences, and long-term morbidity, such as recurrent wheezing or asthma, are not fully understood, both
host- and virus-specific factors appear to contribute to the pathogenesis and/or the outcome of this infection.
The long-term goal of our P01 is to understand the role the mucosa plays in virus- and allergen-induced airway
inflammation and remodeling. We will advance our aims and the field by providing new mechanisms by which
innate viral and allergen stimuli produce epigenetic remodeling, oxidative injury and reprogramming of the
innate mucosal interferon (IFN) response. The purpose of the Infant Bronchiolitis and Viral Core (IBVC) is to
acquire high-quality, clinically annotated mucosal samples from a cohort of young children infected with
respiratory syncytial virus (RSV), and to provide a centralized scientific resource that supports the need for
optimized, homogeneous (highly reproducible) RSV preparations, immunoassay performance, and use of
state-of-the art experimental mouse models of infection, which are required in research project (RP) RP1-RP3
of our P01. Efficient management and distribution of samples and data will ensure the success of the projects.
Furthermore, the IBVC will provide services, technical and intellectual assistance to the P01 Center
investigators in a functional, cost-efficient, and multi-user environment that will enhance the productivity of both
individual and collaborative research programs. In addition to state-of-the-art equipment and methods, the key
personnel of the IBVC provide scientific and technical expertise that greatly benefits the Center investigators in
terms of experimental design, execution and interpretation, as well as, by providing a focus for collaborative
interactions.
项目概要/摘要
呼吸道合胞病毒 (RSV) 可引起儿童一系列疾病,包括上呼吸道疾病
感染严重的下呼吸道疾病,例如细支气管炎和肺炎。虽然
疾病从上呼吸道到下呼吸道进展的决定因素、细支气管炎的严重程度、
复发和长期发病率(例如反复喘息或哮喘)尚不完全清楚
宿主和病毒特异性因素似乎有助于这种感染的发病机制和/或结果。
我们 P01 的长期目标是了解粘膜在病毒和过敏原诱导的气道中所起的作用
炎症和重塑。我们将通过提供新的机制来推进我们的目标和领域
先天病毒和过敏原刺激会产生表观遗传重塑、氧化损伤和细胞重编程
先天粘膜干扰素(IFN)反应。婴儿细支气管炎和病毒核心 (IBVC) 的目的是
从一群感染了新冠病毒的幼儿中获取高质量的、经过临床注释的粘膜样本
呼吸道合胞病毒(RSV),并提供集中的科学资源来支持对呼吸道合胞病毒(RSV)的需求
优化的、均质的(高度可重复的)RSV 制剂、免疫测定性能以及使用
研究项目 (RP) RP1-RP3 所需的最先进的实验小鼠感染模型
我们的P01。样本和数据的有效管理和分发将确保项目的成功。
此外,IBVC将为P01中心提供服务、技术和智力援助
研究人员在功能齐全、经济高效的多用户环境中工作,这将提高双方的生产力
个人和合作研究项目。除了最先进的设备和方法外,关键
IBVC 人员提供的科学和技术专业知识使中心研究人员受益匪浅
实验设计、执行和解释方面,以及通过提供协作焦点
互动。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Roberto P Garofalo其他文献
MyPEEPS Mobile App for HIV Prevention Among Transmasculine Youth: Adaptation Through Community-Based Feedback and Usability Evaluation
用于跨男性青少年艾滋病毒预防的 MyPEEPS 移动应用程序:通过基于社区的反馈和可用性评估进行调整
- DOI:
10.2196/56561 - 发表时间:
2024 - 期刊:
- 影响因子:2.2
- 作者:
Dorcas Adedoja;L. Kuhns;Asa Radix;Roberto P Garofalo;Maeve Brin;Rebecca Schnall - 通讯作者:
Rebecca Schnall
Roberto P Garofalo的其他文献
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{{ truncateString('Roberto P Garofalo', 18)}}的其他基金
Role of the endogenous gasotransmitter H2S in ETS-mediated airway disease
内源性气体递质 H2S 在 ETS 介导的气道疾病中的作用
- 批准号:
9093199 - 财政年份:2016
- 资助金额:
$ 6.27万 - 项目类别:
Role of the endogenous gasotransmitter H2S in ETS-mediated airway disease
内源性气体递质 H2S 在 ETS 介导的气道疾病中的作用
- 批准号:
9272402 - 财政年份:2016
- 资助金额:
$ 6.27万 - 项目类别:
Antiviral Innate Pathways and Superoxide Dismutase in RSV Bronchiolitis
RSV 毛细支气管炎中的抗病毒先天途径和超氧化物歧化酶
- 批准号:
8621088 - 财政年份:2013
- 资助金额:
$ 6.27万 - 项目类别:
Antiviral Innate Pathways and Superoxide Dismutase in RSV Bronchiolitis
RSV 毛细支气管炎中的抗病毒先天途径和超氧化物歧化酶
- 批准号:
8779708 - 财政年份:2013
- 资助金额:
$ 6.27万 - 项目类别:
Chemokine and Protein Patterns in RSV Infection
RSV 感染中的趋化因子和蛋白质模式
- 批准号:
8134693 - 财政年份:2010
- 资助金额:
$ 6.27万 - 项目类别:
Chemokine and Protein Patterns in RSV Infection
RSV 感染中的趋化因子和蛋白质模式
- 批准号:
7392737 - 财政年份:2007
- 资助金额:
$ 6.27万 - 项目类别:
Chemokine and Protein Patterns in RSV Infection
RSV 感染中的趋化因子和蛋白质模式
- 批准号:
6878399 - 财政年份:2004
- 资助金额:
$ 6.27万 - 项目类别:
Epithelial innate signaling in airway inflammation and remodeling
气道炎症和重塑中的上皮先天信号传导
- 批准号:
10205986 - 财政年份:2004
- 资助金额:
$ 6.27万 - 项目类别:
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