O-Specific Polysaccharide Responses and Cholera

O 特异性多糖反应和霍乱

• 批准号: 10372233
• 负责人: Edward T. Ryan
• 金额: $ 73.95万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-07 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10372233
• 关键词: 5 year old; Address; Affect; Antibodies; Antibody Response; Antigens; Bangladesh; Bangladeshi; Binding Sites; Biopsy; Cessation of life; Child; Cholera; Cholera Vaccine; Clinical; Clinical Research; Country; Data; Disease; Ecology; Endoscopy; Evaluation; Gender; Genetic; Goals; Homing; Household; Human; Immune; Immune response; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologics; Ingestion; Institutional Review Boards; International; Intestines; Lymphocyte; Mediating; Mediator of activation protein; Memory B-Lymphocyte; Methods; Modeling; Monoclonal Antibodies; Mucins; Mucosal Immune Responses; Mucous Membrane; Nature; O Antigens; Oral; Patients; Peer Review; Penetration; Plasmablast; Population; Positioning Attribute; Protocols documentation; Public Health; Publications; Reagent; Resources; Sampling; Structure; T-Lymphocyte; Testing; Tissues; Translational Research; Vaccinated; Vaccination; Vaccinee; Vertebral column; Vibrio cholerae; Vibrio cholerae O1; Vibrio cholerae infection; Work; antigen binding; blood group; cell motility; cost; dimer; experience; holotoxins; human monoclonal antibodies; human subject; immunogenic; improved; long term memory; nano; novel; pathogen; programs; response; sound; success; translational medicine; vaccination strategy; vaccine strategy

PROJECT SUMMARY Cholera is a severe dehydrating illness of humans. It is endemic in over 50 countries and causes 3 to 5 million cases a year, resulting in approximately 100,000 deaths. Currently available cholera vaccines have shortcomings. They are often poorly immunogenic in children under the age of 5 years, and often do not induce robust long-term memory responses in immunologically naïve populations. We provide strong preliminary data that antibodies targeting O-specific polysaccharide (OSP) affect Vibrio cholerae and are associated with protection against cholera. We here propose an international clinical study approach to investigate the impact of OSP-specific antibodies on V. cholerae and to define OSP-specific immune responses in humans.

项目概要 霍乱是一种严重的人类脱水疾病，在 50 多个国家流行，导致 3 至 3 人死亡。 目前霍乱每年发生 500 万例，导致约 10 万人死亡。 疫苗有缺点，它们对 5 岁以下儿童的免疫原性通常较差。 数年，并且通常不会在免疫学上幼稚的人中引起强烈的长期记忆反应 我们提供了针对 O 特异性多糖的抗体的强有力的初步数据。 (OSP) 影响霍乱弧菌并与预防霍乱有关。 国际临床研究方法来调查 OSP 特异性抗体对 V 的影响。 霍乱并定义人类 OSP 特异性免疫反应。