Using Longitudinal Research to Engage African American and Latinx Sexual- and Gender-Minority Youth in the HIV Prevention and Care Continua and Reduce HIV/AIDS-Related Disparities

利用纵向研究让非裔美国人和拉丁裔性少数群体青年参与艾滋病毒预防和护理工作并减少与艾滋病毒/艾滋病相关的差距

• 批准号: 10200724
• 负责人: Michele D. Kipke
• 金额: $ 281.48万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10200724
• 关键词: AIDS prevention; AIDS/HIV problem; Accounting; Address; Adherence; Administrative Supplement; African American; Age; Age-Years; Award; Awareness; Caring; Collaborations; Color; Data; Data Collection; Development; Disease Progression; Drug Screening; Drug usage; Epidemic; Fright; Goals; Grant; HIV; HIV Infections; HIV Seronegativity; Health; Healthcare; Immigration; Infection; Interview; Latino; Latinx; Los Angeles; Major Depressive Disorder; Mental Health; Mental disorders; Methods; National Institute of Drug Abuse; Outcome; Participant; Patient Self-Report; Pediatric Hospitals; Pharmaceutical Preparations; Plasma; Policy Maker; Population; Populations at Risk; Process; Quality of life; Reporting; Research; Research Methodology; Research Personnel; Resources; Risk; Sexual and Gender Minority Youth; Sexually Transmitted Diseases; Structure; Surveys; Swab; Testing; Time; Work; Youth; anxious; barrier to care; care systems; cohort; community organizations; comorbidity; drug testing; early childhood; early-career faculty; experience; follow-up; food insecurity; gender minority; gender nonconforming; high risk; improved; infection risk; innovation; interest; marijuana use; men; multi-racial; pre-exposure prophylaxis; prevent; prevention service; racial and ethnic; recruit; rectal; retention rate; sexual HIV transmission; social stigma; stem; transgender; translational pipeline; transmission process; uptake; young adult; young man; young men who have sex with men

The U.S. has set a goal to end the HIV epidemic by the year 2030, which can be achieved but only if targeted approaches are implemented with at-risk populations to address known barriers of engagement along the HIV prevention and care continua. Populations of greatest concern include young men who have sex with men (YMSM), especially YMSM of color, who now account for the vast majority of new HIV infections each year. Transgender and gender non-conforming/non-binary youth are also at high risk for HIV acquisition, accounting for an increasing proportion of new infections each year. In 2015, we were awarded a grant from NIDA to establish a new cohort of 448 African American/Black (AA/B) and Latino YMSM, called the Healthy Young Men’s (HYM) Cohort. We also received an administrative supplement to collect two waves of data from a smaller cohort of B/AA and Latinx 108 transgender and gender nonconforming/non-binary youth (TGMY), called the TRUTH Cohort. Both HYM and TRUTH participants were 16 to 24 years of age at the time of recruitment. The overarching aim was to conduct longitudinal research focused on these youths’ engagement in the HIV prevention and care continua in an effort to prevent new HIV infections, reduce transmission, and reduce HIV/AIDS-related disparities. Mixed methods research is conducted using qualitative interviews, a self- report survey, drug screening, and testing for sexually transmitted infections (STIs) and HIV. Biospecimens (plasma, buffy coat, rectal swabs) are also collected and banked. Analyses performed to date provide clear evidence that participants in both cohorts are at high risk for HIV, drug use, and mental health/psychiatric conditions. Intersectional stigma—i.e., experiences of stigma stemming from multiple, intersecting identities1- 5—also appears to discourage AA/B and Latinx YMSM and TGMY from engaging in care and perhaps may impact their developmental arcs of risk, transmission, and health. Building on this work, we are proposing to longitudinally: i) examine B/L-YMSM’s engagement in the HIV prevention and care continua, as well as their developmental transitions and trajectories in drug use, STI/HIV infection, health, and psychiatric/mental health comorbidities (Aim 1); ii) examine TGMY’s engagement in the HIV prevention and care continua and identify shared and unique transitions and trajectories with respect to TGMY’s use of drugs, infections with STI/HIV, health and psychiatric/mental health comorbidities (Aim 2); and iii) serve as a local and national resource for collaborations and dissemination. We will actively participate in and contribute to the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO), the Coordinating Center for NIDA’s U01 cohorts. We will also partner with key stakeholders (e.g., community organizations, policy makers) and collaborate with trainees, early career faculty and investigators across the translational spectrum (Aim 3).

美国设定了一个目标，以结束艾滋病毒的流行，到2030年，这可以痛苦，但仅在针对目标的情况下才是 通过处于危险的人口中实施方法，以解决艾滋病毒沿线的已知互动障碍 预防和关怀连续性。 （YMSM），尤其是YMSM的颜色，现在他们现在每年都会占绝大多数新的艾滋病毒感染。 跨性别和性别不合格/非二进制青年也有艾滋病毒剥夺，会计的高风险 对于每年越来越多的新感染的建议。 建立一个新的448个非洲裔美国/黑色（AA/B）和拉丁裔YMSM的队列，称为健康的年轻人 男子（赞美诗）同类 B/AA和Latinx 108跨性别者和性别不合格/非二进制青年（TGMY）的较小队列， 称为真相队列。 招聘。 在艾滋病毒和连续性的艾滋病毒中，以防止新的艾滋病毒感染，减少传播，并 减少艾滋病毒/艾滋病相关的差异。 报告调查，药物筛查和性传播感染（STI）和生物测量的测试 （血浆，Buffy Coat，直肠拭子）也收集并进行分析。 两个队列中的tharticants都有艾滋病毒，吸毒和心理健康/精神病的高风险 条件。 5-似乎也阻止AA/B和Latinx YMSM和TGMY从事护理，也许可能 我们建议的是，他们正在影响他们的风险，传播和健康。 纵向：i）检查b/l-ymsm在艾滋病毒预防和teir中的参与 毒品使用，STI/HIV感染，健康和精神/心理健康的发展过渡和轨迹 合并症（目标1）； 关于TGMY使用药物的共享和独特的过渡和轨迹，感染感染/艾滋病毒， 健康和精神病/心理健康专辑（AIM 2）； 我们将积极参与并为合作联盟做出贡献。 在NIDA U01的协调中心，生产NIDA机会（C3PNO） 还与关键利益相关者（例如社区组织，政策制定者）​​合作，并与 翻译范围内的学员，早期职业教师和调查人员（AIM 3）。