Project 1

项目1

基本信息

批准号：
10360625
负责人：
DAVID D LO
金额：
$ 38.34万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-08 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10360625
关键词：
Aerosols Affect Agriculture Allergens Asthma Biocompatible Materials Biological Biological Assay Chemicals Chronic Chronic Obstructive Pulmonary Disease Clinical Collaborations Collection Communication Communities Consultations Data Databases Dust Employment Environmental Exposure Environmental Health Epidemiology Exposure to Family Geography Health Health Disparities Research Housing Incidence Inflammatory Response Infrastructure Latino Lead Lung Maps Modeling Monitor Movement Network-based Outcome Particulate Pattern Plants Population Protocols documentation Pulmonary Heart Disease Pulmonary Inflammation Research Research Project Grants Resources Sea Seasonal Variations Site Socioeconomic Status Source Testing Vascular Diseases Work aerosolized base community engagement health disparity improved interdisciplinary approach lung health marine organism microbial mineral dust mouse model particle pollutant pollutant transport programs remote sensing soil sampling trend water sampling

项目摘要

U54 Research Project 1: Disparities in environmental exposures and health impacts Abstract The main premise of the proposed research is that health disparities in the eastern Coachella Valley (ECV), especially with regard to asthma and cardiopulmonary disease within the Latino community, are significantly affected by differential chronic environmental exposures to aerosols including biological materials (e.g., allergens and microbial components). To focus on the specific question of environmental exposures and health, we aim to develop a monitoring protocol and database that would allow us to assess correlates between aerosolized particulate components, effects on pulmonary inflammatory responses, and the epidemiology of asthma and other cardiopulmonary diseases in the Coachella Valley. We aim to accomplish this in conjunction with a community advisory board to enable continuous community engagement. The research program will include transport studies to identify patterns of particle/pollutant transport in the Coachella Valley, collection of particulate, soil and water samples in and near the Salton Sea to track the origins and movement of biological components in aerosols, and exposure of the collected material in mouse models to identify materials that may contribute to lung inflammation and asthma in the community.

U54研究项目1：环境暴露和健康影响的差异抽象的拟议研究的主要前提是东部的健康差异 Coachella Valley（ECV），特别是关于哮喘和心肺疾病拉丁裔社区受到差异慢性环境暴露的影响到包括生物材料（例如，过敏原和微生物成分）在内的气溶胶。集中精力关于环境暴露和健康的具体问题，我们旨在开发监控协议和数据库，该协议和数据库可以评估雾化颗粒之间的相关性成分，对肺部炎症反应的影响以及哮喘的流行病学以及Coachella Valley的其他心肺疾病。我们的目标是在与社区顾问委员会的结合，以实现持续的社区参与。研究计划将包括运输研究以识别粒子/污染物的模式在Coachella Valley中运输，收集颗粒物，土壤和水样在附近和附近索尔顿海跟踪气溶胶中生物成分的起源和运动，在鼠标模型中接触收集的材料，以识别可能有助于社区中的肺部炎症和哮喘。