2015 Muscle: Excitation/Contraction Coupling Gordon Research Conference & Gordon Research Seminar

2015年肌肉：兴奋/收缩耦合戈登研究会议

• 批准号: 8825143
• 负责人: Robert T Dirksen
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8825143
• 关键词: Addendum; Aging; Area; Atrophic; Back; Basic Science; Calcium Signaling; Clinical; Clinical Research; Communication; Communities; Coupling; Defect; Development; Discipline; Disease; Elements; Environment; Functional disorder; Gender; Geographic Locations; Goals; Government; Growth; Health; Human; Individual; Inherited; International; Knowledge; Lead; Leadership; Maintenance; Metabolic Diseases; Metabolism; Modification; Molecular; Muscle; Muscle Fatigue; Mutation; Myocardium; Myopathy; Neuromuscular Diseases; Outcome; Oxidation-Reduction; Participant; Patients; Performance; Postdoctoral Fellow; Process; Proteins; Quality of life; Race; Regulation; Research; Research Personnel; Resolution; Resort; Rivers; Roentgen Rays; Ryanodine Receptor Calcium Release Channel; Scientist; Site; Skeletal Muscle; Staging; Structure; Students; Switzerland; Time; Translational Research; Triad Acrylic Resin; Universities; University Hospitals; Work; base; career; combat; effective therapy; experience; graduate student; improved; innovation; insight; meetings; muscle metabolism; new therapeutic target; news; novel; novel strategies; posters; programs; public health relevance; sarcopenia; symposium

 DESCRIPTION (provided by applicant): This is a proposal for partial support of the only major national or international meeting dedicated to excitation/contraction coupling and how defects in this critical process underlie muscle disease. The Muscle: Excitation/Contraction Coupling (ECC) Gordon Research Conference (GRC) will meet from May 30 - June 5, 2015 at the new Sunday River Resort GRC site in Newry, ME. The GRC program was developed by an Executive Organizing Committee consisting of leaders in ECC research including Drs. Robert T. Dirksen (University of Rochester), Susan Treves (Basel University Hospital), and Isaac N. Pessah (UC Davis). The two overarching objectives of the 2015 Muscle: Excitation/Contraction Coupling GRC are: Objective 1: To discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control ECC and how this process is altered in muscle fatigue, atrophy, sarcopenia, metabolic disease, and genetically-inherited forms of skeletal and cardiac muscle disease. Objective 2: To promote visibility and leadership of junior investigators in the field by providing a platform for students, postdoctoral fellows, and new independent investigators to present their work, as well as to interact and network with established senior investigators. The 2015 GRC conference will consist of 35 speakers, 18 Discussion Leaders, and 16 poster presentations. Scientific sessions will focus on structural studies of the ECC apparatus, new insights into the molecular mechanisms and regulation of ECC, identification of new therapeutic targets, and the development of innovative treatments for muscle fatigue, sarcopenia, and skeletal and cardiac muscle disorders that adversely impact millions of individuals in the US. For the first time for this GRC, the meeting will be preceded by a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows. In addition, a different young investigator will be paired with a senior investigator to serve as Co-Discussion Leaders for sessions during the GRC. Innovative "Rapid Poster Preview" and "This Just In" speaker slots will be used to highlight late-breaking news. These innovative program elements will also maximize poster session visibility, as well as to enhance the integration and exposure of promising young investigators in the field during the GRC. We expect that this conference will attract 150-200 basic and clinical scientists across all career stages, genders, races, heritages, research disciplines, professional affiliations (academic, industrial, government), and geographical locations. Our overall aim is to promote: 1) open dialogue and communication, 2) exposure and career advancement of promising young investigators in the field, 3) fundamental understanding in the mechanisms of ECC and how defects in this process lead to compromised muscle performance, and 4) the development of novel and effective therapies to combat skeletal and cardiac muscle disorders.

 描述（由申请人提供）：这是对唯一一个致力于兴奋/收缩耦合以及这一关键过程中的缺陷如何导致肌肉疾病的主要国家或国际会议的部分支持的提案：肌肉：兴奋/收缩耦合（ECC）戈登。研究会议 (GRC) 将于 2015 年 5 月 30 日至 6 月 5 日在缅因州纽里的新 Sunday River Resort GRC 地点举行。GRC 计划由由领导人组成的执行组织委员会制定。 ECC 研究人员包括 Robert T. Dirksen 博士（罗切斯特大学）、Susan Treves（巴塞尔大学医院）和 Isaac N. Pessah（加州大学戴维斯分校）。 2015 年肌肉：兴奋/收缩耦合 GRC 的两个总体目标是：目标 1：讨论和批判性评估关于控制 ECC 的分子机制的新突破，以及该过程如何在肌肉疲劳、萎缩、肌肉减少症、代谢性疾病和目标 2：通过为学生、博士后研究员和新的独立研究人员提供展示其工作以及互动和交流的平台，提高该领域初级研究人员的知名度和领导力。 2015 年 GRC 会议将由 35 名演讲者、18 名讨论领袖和 16 场海报演讲组成，重点讨论 ECC 装置的结构研究、分子机制的新见解和此次 GRC 会议将首次讨论 ECC 的监管、新治疗靶点的确定以及针对肌肉疲劳、肌肉减少症以及骨骼和心肌疾病的创新疗法的开发，这些疾病对美国数百万人产生了不利影响。在此之前，将为研究生和博士后研究员举办为期两天的戈登研究研讨会 (GRS)。此外，另一位年轻研究员将与一名高级研究员配对，担任 GRC 创新会议期间的共同讨论领导者。 “快速海报预览”和“This Just In”演讲时段将用于突出最新突发新闻，这些创新的节目元素还将最大限度地提高海报会议的可见度，并增强该领域有前途的年轻研究人员的整合和曝光。我们预计本次会议将吸引 150-200 名来自各个职业阶段、性别、种族、传统、研究学科、专业背景（学术、工业、政府）和地理位置的基础和临床科学家。到促进：1）公开对话和交流，2）该领域有前途的年轻研究人员的接触和职业发展，3）对 ECC 机制的基本了解以及该过程中的缺陷如何导致肌肉性能受损，以及 4）发展对抗骨骼和心肌疾病的新颖有效的疗法。