Biostatistics Shared Resource

生物统计共享资源

基本信息

批准号：
8682938
负责人：
DANIEL J. SARGENT
金额：
$ 57.63万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-25 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8682938
关键词：
Area Authorship Basic Science Biostatistics Shared Resource Cancer Center Support Grant Cancer Patient Charge Clinical Clinical Trials Clinical Trials Design Collaborations Comprehensive Cancer Center Data Data Analyses Development Doctor of Philosophy Epidemiologic Studies Faculty Family Caregiver Funding Genetic Genomics Grant Intervention Leadership Malignant Neoplasms Mayo Clinic Cancer Center Measurement Molecular Epidemiology NCI Center for Cancer Research Observational Study Patient Education Peer Review Pilot Projects Population Sciences Proteomics Publications Quality of life Research Research Personnel Research Project Grants Surrogate Endpoint Survival Analysis Translational Research United States National Institutes of Health Work data management genetic epidemiology member psychosocial public education tool

项目摘要

The Biostatistics Shared Resource (BSR) of the Mayo Clinic Cancer Center (MCCC), under the leadership of Dr. Daniel Sargent, PhD (since 2001) has provided expert statistical collaboration with MCCC investigators for over 40 years for the development and conduct of peer-reviewed cancer center research encompassing basic science, clinical trials, epidemiologic research, and other translational and educational research. The primary usage of CCSG funds within the BSR is to support statistical collaboration on pilot projects, for assistance to investigators in developing approved research projects not otherwise funded but leading towards external funding, and to support unanticipated needs for statistical collaboration on MCCC approved projects. Funding is primarly provided to protect FTE of key faculty members to collaborate with MCCC members at no charge; funding is also provided to select senior MS statisticans for work on approved MCCC projects. In the current grant period the BSR has successfully and strategically firmly established high dimensional genomic and proteomic data analysis, and a robust presence at all 3 MCCC campuses. BSR faculty includes statistical methodological research leaders in clinical trial design, survival analysis, high-dimensional data, statistical genetics, quality of life research, and surrogate endpoints. The BSR has three focus areas (teams) tied together into a well-organized, efficient core. These are: (I) a Clinical Trials team responsible for cancer clinical trials, associated translational research, and patient and public education research projects, (11) a Population Science/Computational Genomics team responsible for statistical collaboration and data management support for high dimensional data analyses and cancer observational studies, including genetic and molecular epidemiology, and (III) a Quality of Life team responsible for collaboration, measurement tools, and analysis for MCCC investigators investigating the impact of clinical and psychosocial interventions on cancer patients, families, caregivers, and others. The BSR has been remarkably productive, with authorship on 833 peer reviewed publications and collaborations on 63 NIH or NIH-equivalent grants in the current grant period.

梅奥诊所癌症中心 (MCCC) 的生物统计共享资源 (BSR)，在 Daniel Sargent 博士（自 2001 年起）与 MCCC 研究人员提供专家统计合作 40 多年来致力于开发和开展同行评审的癌症中心研究，包括基础科学、临床试验、流行病学研究以及其他转化和教育研究。这 BSR 内 CCSG 资金的主要用途是支持试点项目的统计合作，协助研究人员开发经批准的研究项目，这些项目没有其他资助，但处于主导地位寻求外部资金，并支持已批准的 MCCC 统计合作的意外需求项目。资金主要用于保护与 MCCC 合作的主要教职人员的 FTE 会员免费；还提供资金来选拔高级 MS 统计学家，从事经批准的 MCCC 工作项目。在当前的资助期内，BSR 已成功并战略性地牢固地建立了高水平三维基因组和蛋白质组数据分析，并在 MCCC 的所有 3 个校区拥有强大的影响力。缓冲状态报告教员包括临床试验设计、生存分析、高维统计方法学研究领导者数据、统计遗传学、生活质量研究和替代终点。 BSR 将三个重点领域（团队）联系在一起，形成一个组织良好、高效的核心。它们是：（一）临床试验团队负责癌症临床试验、相关转化研究以及患者和公共教育研究项目，（11）人口科学/计算基因组学团队，负责高维数据分析和癌症的统计协作和数据管理支持观察性研究，包括遗传和分子流行病学，以及 (III) 生活质量团队负责为调查 MCCC 调查人员提供协作、测量工具和分析临床和社会心理干预对癌症患者、家庭、护理人员和其他人的影响。这 BSR 卓有成效，拥有 833 篇同行评审出版物和合作成果当前资助期内 63 项 NIH 或 NIH 同等资助。