Low Back Pain in Parkinson Disease

帕金森病的腰痛

基本信息

批准号：
10362616
负责人：
Ryan P Duncan
金额：
$ 11.31万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-10 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10362616
关键词：
Address Affect Age Aging Anxiety Area Articular Range of Motion Behavior Biomechanics Characteristics Clinical Complement Complication Constipation Development Development Plans Disabled Persons Disease Education Elderly Exercise Failure Foundations Fright Future General Population Goals Health Impaired cognition Impairment Institution International Intervention Investigation Isotonic Exercise Lead Low Back Pain Low Prevalence Measures Mental Depression Mentors Mentorship Mission Modeling Morbidity - disease rate Movement Movement Disorders Muscle Musculoskeletal Pain Nature Neurologic Non-Steroidal Anti-Inflammatory Agents Operative Surgical Procedures Opioid Analgesics Pain Pain Nature Pain Threshold Parkinson Disease Patients Persons Pharmacology Physical activity Physical therapy Play Population Posture Quality of life Regression Analysis Research Research Personnel Role Sampling Sensory Severities Shapes Testing Therapeutic Intervention Time Training Universities Washington Work career career development conditioned pain modulation disability effective intervention effective therapy flexibility improved improved mobility insight medical schools nervous system disorder pain processing pain relief pain-related disability patient population pressure prevent psychologic reduce symptoms rehabilitation management research and development sex statistics therapeutic development therapy development

项目摘要

Project Summary Low back pain (LBP) is the most prevalent secondary condition in Parkinson disease (PD), affecting up to 74% of patients. In the general population, LBP causes significant morbidity, but the effect of LBP in patients with PD is not well understood and treatment options are lacking. Non-steroidal anti-inflammatory drugs provide insufficient pain relief. Opioid pain medications are addictive and may worsen PD manifestations like cognitive impairment and constipation. Surgery has high failure and complication rates in PD. Consequently, LBP is often not addressed. Physical therapy effectively reduces LBP in the general population and may provide an effective treatment option for LBP in patients with PD. However, people with PD have disease-specific characteristics that warrant consideration in treatment development. As such, tailoring physical therapy for LBP in PD requires a better understanding of the multi-factorial nature of LBP in this population. The overall goal of this cross-sectional investigation is to comprehensively characterize LBP in PD. We will determine whether and how factors known to contribute to LBP (e.g., biomechanical, sensory, and psychologic impairments) differ between people with PD and older adults. Further, we will explore how these impairments contribute to LBP-related disability in people with PD. Our central hypothesis is that LBP in PD is different (i.e., greater severity of biomechanical, sensory, and psychologic impairments) from LBP in older adults. This investigation complements NCMRR’s mission to enhance health and quality of life in people with disabilities by beginning to understand LBP in PD. This study will help to inform the development of effective interventions to address it. Dr. Duncan’s career goal is to understand and ultimately prevent or reduce the burden of secondary musculoskeletal pain conditions in people with primary neurologic disease. Dr. Duncan’s career development plan will focus on education in the following areas: 1) the multi-factorial nature of pain from a clinical perspective, 2) the interaction between pain and PD, and 3) advanced statistics (e.g., multiple regression modeling). Dr. Duncan will receive mentorship from Dr. Joel Perlmutter and Dr. Linda Van Dillen, who are world-renowned experts in PD and LBP, respectively. This investigation will take place at Washington University in St. Louis School of Medicine, an internationally acclaimed research institution. The Movement Disorders Center, which follows more than 2,500 people with PD, will provide more than sufficient access to the sample required for this investigation. Information gained from this study will lay the foundation for development of therapeutic interventions for LBP in PD, which may reduce disability and improve quality of life.

项目摘要腰痛（LBP）是帕金森病（PD）中最普遍的次要疾病，高达74％在一般人群中，LBP会引起明显的病态，但LBP的影响 PD不太了解，缺乏治疗选择。止痛药不足。障碍和施工通常没有解决物理疗法。在PD患者中，LBP的有效治疗选择。保证在治疗开发中考虑的特征。在PD中，需要更好地了解该人群中LBP的多因素自然。横截面投资的总体目标是全面地描述了PD的LBP 确定已知因素以及如何促进LBP的因素（例如，生物力学，感觉和心理学障碍）PD和老年人之间有所不同。 PD患者中与LBP相关的残疾有助于。老年人的LBP的生物力学，感觉和心理障碍的严重程度更大调查COMRR的使命在残疾人中的健康和生活质量。开始了解PD的LBP。邓肯博士的职业目标是理解并最终预防或减轻中学的负担原发性神经疾病的人的肌肉疼痛状况。计划将重点关注以下领域的教育：1）临床上疼痛的多因素性质透视图，2）疼痛与PD之间的相互作用，以及3）高级统计（例如，多重回归 Duncan博士将获得Joel Perlmutter博士和博士的指导。 PD和LBP的世界知名专家将在华盛顿进行。在国际知名的研究所，路易斯大学的大学遵循2500多人PD的疾病中心将提供更多的机会调查所需的样本。在PD中开发LBP的治疗性介入，这可能会降低拒绝性并改善生活质量。