Pathology Core

病理学核心

• 批准号: 10356012
• 负责人: ROBERT A. ANDERS
• 金额: $ 11.17万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10356012
• 关键词: Acute Hepatitis; Address; Alcohol abuse; Alcoholic Hepatitis; Alcoholic Liver Diseases; Basic Science; Biological; Cataloging; Chronic; Clinical; Clinical Data; Collaborations; Collection; Data; Databases; Disease; Formalin; Fostering; Freezing; Harvest; Life; Link; Liquid substance; Liver; Medical; National Cancer Institute; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patient Care; Patients; Practice Guidelines; Recording of previous events; Research; Research Personnel; Resource Sharing; Resources; Sampling; Services; Specimen; Supervision; Surgeon; System; Time; Tissue Banks; Tissue Sample; Tissues; Transplant Recipients; Transplantation; Universities; Work; animal tissue; biobank; disorder control; human tissue; interdisciplinary approach; liver transplantation; member; mortality; programs; translational impact

PROJECT SUMMARY The purpose of this shared resource is to provide human tissues, biological fluids, and expert pathologic interpretation for project investigators. The Pathology Core will work with an existing resource, the GI SPORE Tissue Bank, which is under the same director (Dr. R. Anders) as this proposed Pathology Core, to establish a collection of properly banked liver tissue and biological fluids. The tissue samples will range from formalin- fixed paraffin-embedded and frozen tissues available from liver transplantation specimens which will be linked to clinical data. This Pathology Core will collect high quality snap frozen and formalin fixed samples from liver transplant patients. The biospecimens will be harvested and banked in accordance with the National Cancer Institute’s Best Practice Guidelines for Biorepositories. Distribution of these specimens to project investigators will be coordinated by the Pathology Core director. This CORE will procure specimens under the supervision of a pathologist with expertise in hepatopathology and in close collaboration with surgeons, transplant hepatologists and basic research investigators to maximize translational impact of the projects. This proposed CORE will leverage existing database framework, specimen distribution and prioritization systems that originated from existing SPORES. Specifically, we will have clinical histories linked to pathologic data in a password protected database. A mechanism will be in place for prioritization of distribution of requested resources to investigators within and external to the Johns Hopkins Medical System.

项目摘要 共享资源的目的是提供人体组织，生物液和专家病理学 项目调查人员的解释。病理核心将与现有资源（GI孢子）一起使用 组织库（R. Anders博士）与该拟议的病理核心相同的董事（R. Anders博士），以建立一个 收集适当的肝组织和生物液。组织样品的范围从福尔马林 - 固定的石蜡包裹和冷冻的组织可从肝移植样品可用 到临床数据。该病理核心将收集肝脏的高质量快照和福尔马林固定样品 移植患者。将根据国家癌症收获和储存生物测量 研究所的生物局限器的最佳实践指南。将这些物种分配给项目调查人员 病理核心主任将协调。该核心将在 具有肝病学专业知识的病理学家，并与外科医生，移植密切合作 肝病学家和基础研究研究人员最大程度地提高了这些项目的翻译影响。这提出了 核心将利用现有的数据库框架，标本分布和优先级系统 起源于现有孢子。具体而言，我们将拥有与病理数据有关的临床历史 密码保护数据库。将有一种机制来确定要求的分配 向约翰霍普金斯医疗系统内部和外部的调查人员提供资源。