Immune Responses to Malaria and HIV Infection and Immunization

对疟疾和艾滋病毒感染的免疫反应和免疫接种

• 批准号: 10198675
• 负责人: KENNETH D STUART
• 金额: $ 356.11万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198675
• 关键词: AIDS/HIV problem; Communicable Diseases; Communities; Disease; Environmental Exposure; Foundations; Goals; HIV; HIV Infections; HIV immunization; HIV-1; Health Status; Human; Immune; Immune response; Immune system; Immunity; Immunology; Infection; Malaria; Molecular Profiling; Pathway Analysis; Plasmodium falciparum; Population; Research; Systems Biology; Technology; Vaccination; Vaccine Adjuvant; Vaccines; data standards; design; insight; malaria infection; pathogen; response; vaccine development; vaccine efficacy

Malaria and HIV/AIDS are two of the most devastating infectious diseases, impacting millions of people world- wide. Effective vaccines against the pathogens that cause these diseases (HIV and Plasmodium falciparum) have proven elusive and traditional vaccine approaches are unlikely to succeed in eradicating either disease. In addition to our limited understanding of the desired immune responses to confer protection against the pathogens and our limited ability to elicit such responses, vaccine efficacy is also confounded by the diversity of pathogens, human populations, environmental exposures, and health status. The projects described herein are designed to support the identification of immune profiles that correlate with vaccine efficacy and are of potential relevance to protection against HIV-1 and P. falciparum infection. Beyond the importance of combatting these diseases, the strategies for profiling immunity in response to infection and vaccination hold promise for garnering fundamental insights into the complexity of the immune system as a whole. Such insight will have potential for impacting strategies for vaccine development and for treating immune-related diseases more broadly.

疟疾和艾滋病毒/艾滋病是两种最具破坏性的传染病，影响了数百万的世界 - 宽的。对引起这些疾病的病原体（HIV和恶性疟原虫）的有效疫苗 经过证明的难以捉摸的传统疫苗方法不太可能成功地消除任何一种疾病。 除了我们对所需免疫反应的有限理解以赋予保护 病原体和我们引起此类反应的有限能力，疫苗功效也被多样性混淆 病原体，人群，环境暴露和健康状况。此处描述的项目 旨在支持与疫苗功效相关的免疫特征的识别，并且 与保护HIV-1和恶性疟原虫感染的潜在相关性。超越重要性 打击这些疾病，响应感染和疫苗接种的疾病的策略策略 希望获得对整个免疫系统复杂性的基本见解。这样的见解 将有可能影响疫苗开发和治疗免疫相关疾病的策略 更广泛。