A Hub for the Nuclear Receptor Signaling Atlas1

核受体信号图谱的枢纽1

基本信息

批准号：
8730648
负责人：
RONALD M EVANS
金额：
$ 165万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-17 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8730648
关键词：
Academia Achievement Androgen Receptor Anthelmintics Atlases Bioinformatics Cells Circadian Rhythms Communities Complex Computer software Data Analyses Data Set Data Sources Development Diabetes Mellitus Discipline Disease Endocrinology Funding Funding Mechanisms Funding Opportunities Gene Targeting Generations Genes Genome Genomics Government Hematology Individual Industry Inflammation Institutes Internet Investments Journals Literature Macrophage Activation Mails Malignant Neoplasms Measures Metabolic Pathway Metabolism Methods Metric Molecular Molecular Profiling National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Environmental Health Sciences Nature Neurosciences Nuclear Receptors Obesity Output Paper Peptides Phage Display Proteomics Protocols documentation PubMed Publications Publishing Receptor Signaling Regulation Research Research Personnel Research Project Grants Resources Role Science Site Software Tools Techniques Testing Therapeutic Time Tissues United States National Institutes of Health Validation Visit Writing base bone catalyst cell growth regulation chromatin modification epigenomics inhibitor/antagonist member metabolomics nervous system disorder novel outreach programs promoter protein protein interaction public health relevance response senescence small molecule sound success therapeutic target tool transcriptomics tumor metabolism user-friendly web site

项目摘要

DESCRIPTION (provided by applicant): Over the past decade the field of NR signaling has generated a large volume of global datasets that collectively describe sequences of NR and coregulator genes (genomics); the regulation by NRs and coregulators of gene networks in specific target tissues (transcriptomics); protein-protein interactions required for the efficient function of NRs and coregulators (proteomics); specific sites of action of NRs in target gene promoters (cistromics); covalent modification of chromatin (epigenomics); and, more recently, specific functional endpoints in the form of regulation of cellular metabolic pathways (metabolomics). In order to effectively leverage these resources, we propose the continued development of the Nuclear Receptor Signaling Atlas (NURSA) web resource that will assemble and integrate these datasets, build user-friendly data analysis tools and present these to the community for hypothesis generation and validation. To fully engage the research community, we propose to administer a program of NURSA Data Source Projects (NDSPs) that will generate new global scale datasets that will be submitted to the website and integrated with existing datasets. We will also engage in outreach efforts that will offer members of the research community to participate in NURSA as Affiliate members, as well as in testing software tools during their development. With the involvement of the community, we anticipate that NURSA will be an important research resource for this field.

描述（由申请人提供）：在过去的十年中，NR 信号传导领域已经生成了大量的全球数据集，这些数据集共同描述了 NR 和辅助调节基因的序列（基因组学）；特定靶组织中基因网络的 NR 和共调节因子的调节（转录组学）； NR 和辅助调节因子有效发挥功能所需的蛋白质-蛋白质相互作用（蛋白质组学）；靶基因启动子中 NR 的特定作用位点（顺反组学）；染色质的共价修饰（表观基因组学）；最近，以细胞代谢途径（代谢组学）调节形式出现的特定功能终点。为了有效地利用这些资源，我们建议继续开发核受体信号图谱（NURSA）网络资源，该资源将组装和集成这些数据集，构建用户友好的数据分析工具，并将这些工具呈现给社区以进行假设生成和验证。为了充分参与研究界，我们建议管理 NURSA 数据源项目 (NDSP) 计划，该计划将生成新的全球规模数据集，这些数据集将提交到网站并与现有数据集集成。我们还将开展外展工作，为研究社区成员提供作为附属成员参与 NURSA 的机会，并在软件工具的开发过程中对其进行测试。在社区的参与下，我们预计 NURSA 将成为该领域的重要研究资源。