Integrative Health Sciences Facility Core

综合健康科学设施核心

基本信息

批准号：
10189588
负责人：
Anil Vachani
金额：
$ 35.32万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10189588
关键词：
Address Affect Air Pollutants Air Pollution Area Back Basic Science Big Data Bioinformatics Biological Biological Markers Biology Biometry Biosensor Cells Clinical Clinical Research Clinical Trials Collection Communication Communities Core Facility Data Database Management Systems Development Disease Disease Management Electronic Health Record Electronic cigarette Environmental Exposure Environmental Health Exposure to Fostering Health Health Sciences Human Human Resources Individual Informatics Information Dissemination Institutional Review Boards Integrative Medicine Intervention Trial Laboratories Lung Measures Mission Nature Neurosciences Observational Study Outcome Participant Patients Performance Phenotype Pilot Projects Population Population Sciences Predisposition Process Prognostic Marker Public Health Publications Questionnaires Reader Recording of previous events Research Research Design Research Personnel Research Subjects Research Support Resources Retrospective Studies Risk Sampling Services Specimen Handling Statistical Data Interpretation Statistical Methods Technology Testing Therapeutic Intervention Toxicant exposure Toxicokinetics Training Activity Training Support Translating Translational Research Translations Vision Work adverse outcome analytical method base biobank biomarker validation biomedical informatics combustible cigarette community based participatory research community engagement data management density design disorder risk environment related cancer environmental toxicology epidemiology study exposed human population fundamental research genetic information high dimensionality human subject imaging study innovation member non-genetic novel patient oriented research pre-clinical preclinical study predictive marker prevent preventive intervention quality assurance recruit tool training opportunity translational study vapor virtual

项目摘要

INTEGRATIVE HEALTH SCIENCES FACILITY CORE (IHSFC): ABSTRACT The IHSFC is the entity that enables CEET investigators to perform translational environmental health research that impacts individuals and communities. Its mission includes (1) support of the translation of basic science observations that relate environmental exposures to adverse outcomes into human studies that detect, prevent and/or manage diseases induced or exacerbated by these exposures and (2) to translate EHS questions derived from the community into testable hypotheses that can be addressed with human studies. Services provided by the IHSFC to CEET investigators include: (a) Human Studies Design and Performance Services, (b) Population Exposure Services, (c) Pre-clinical and Human Exposure Laboratories, (d) the CEET Virtual Biorepository and (e) Biostatistics Services. The Population Exposure Services now has expertise in GIS technology, ArcGIS tools, cartographic mapping, geospatial analysis to measure the external exposome. Population science-based projects that require biomarker support in the study design are referred to the Translational Biomarker Core, and those that generate “big-data” in their study design are referred to the Exposure Biology Informatics Core. The IHSFC acts as a bridge to the Community Engagement Core (CEC) and communicates in a bi-directional manner to formulate community-based questions and concerns into specific hypotheses for CEET investigators to address by research and communicate results of the studies back to community members. Studies supported by the IHSFC include those involving the integrated thematic areas of Air Pollution & Lung Health, Environmental Exposures & Cancer, Windows-of-Susceptibility and Environmental Neuroscience, as well as novel studies initiated via pilot projects. Over the past four years, the IHSFC has supported 51 separate studies involving 28 different CEET investigators that have generated 46 publications. Efforts by the IHSFC will ultimately result in achieving Precision Public Health (PPH) - the prediction of who is at risk of exposure, who is at risk for disease, and the identification of predictive and prognostic biomarkers.

综合健康科学设施核心 (IHSFC)：摘要 IHSFC 是使 CEET 研究人员能够进行转化环境健康研究的实体其使命包括 (1) 支持基础科学的翻译。将环境暴露与不良后果联系起来的观察结果纳入人类研究中，以发现、预防和/或管理由这些暴露诱发或加剧的疾病，以及 (2) 翻译衍生的 EHS 问题从社区转化为可检验的假设，这些假设可以通过人类研究服务来解决。 IHSFC 到 CEET 的调查人员包括：(a) 人类研究设计和绩效服务，(b) 人口暴露服务，(c) 临床前和人体暴露实验室，(d) CEET 虚拟生物样本库和 (e) 生物统计服务部门现在拥有地理信息系统技术、ArcGIS 方面的专业知识。工具、制图、地理空间分析来测量基于人口科学的外部暴露。在研究设计中需要生物标志物支持的项目被称为转化生物标志物核心，并且那些在研究设计中生成“大数据”的被称为暴露生物学信息学核心。 IHSFC 充当社区参与核心 (CEC) 的桥梁并以双向方式进行通信将基于社区的问题和关切制定为具体假设，供 CEET 调查人员通过研究发表演讲并将研究结果传达给社区成员支持的研究。 IHSFC 的项目包括涉及空气污染与肺部健康、环境等综合主题领域的项目暴露与癌症、易感性窗口和环境神经科学以及新颖的研究在过去四年中，IHSFC 通过试点项目发起了 51 项独立研究，涉及 28 项。 IHSFC 的不同 CEET 研究人员已发表 46 篇论文，最终将产生结果。实现精准公共卫生 (PPH) - 预测谁有暴露风险、谁有患病风险、以及预测和预后生物标志物的鉴定。