Center to Accelerate Translation of Interventions to Decrease Premature Mortality in SMI

加速转化干预措施以降低 SMI 过早死亡率的中心

• 批准号: 10188636
• 负责人: Gail L. Daumit
• 金额: $ 153.34万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188636
• 关键词: Address; Adopted; Adoption; Advocacy; Behavior Therapy; Behavioral; Behavioral Research; Body Weight decreased; Cardiovascular Diseases; Caring; Cessation of life; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication Methods; Communities; Consultations; Criminal Justice; Development; Diabetes Mellitus; Diet; Discipline; Dyslipidemias; Engineering; Evidence based intervention; Evidence based practice; Faculty; Family member; Foundations; Funding; Future; Gap Junctions; Goals; Health; Health Personnel; Health Services Research; Health behavior change; Health system; Homelessness; Human; Hypertension; Individual; Intervention; Intervention Studies; Life Expectancy; Maryland; Medical; Mental Health; Mentorship; Methods; Obesity; Organizational Policy; Persons; Physical activity; Policy Maker; Population; Premature Mortality; Provider; Public Health; Quality of Care; Research; Research Methodology; Research Personnel; Resources; Risk Behaviors; Risk Factors; Science; Services; Smoking Cessation Intervention; Speed; System; Testing; Time; Tobacco smoking behavior; Training; Translating; Translations; Unhealthy Diet; Vision; Vulnerable Populations; cardiovascular disorder risk; cardiovascular risk factor; care delivery; cohort; comorbidity; design; effective intervention; evidence base; experience; health care service organization; health communication; health equity; implementation science; implementation strategy; improved; innovation; interest; medical specialties; mortality; mortality disparity; motivational enhancement therapy; peer; physical inactivity; premature; research study; research to practice; response; scale up; severe mental illness; smoking cessation; social; synergism; system-level barriers; years of life lost

Persons with serious mental illness (SMI) comprise one of the most highly vulnerable groups in the US, dying 10 to 20 years earlier and with mortality rates two to over three times higher than the overall population. Much of this premature death is attributable to cardiovascular disease (CVD) and is potentially preventable; all CVD risk behaviors (unhealthy diet, physical inactivity, tobacco smoking) and risk factors (obesity, hypertension, diabetes and dyslipidemia) are markedly elevated in persons with SMI. Concomitantly, persons with SMI often receive poor quality of care for these conditions. While these health and mortality gaps are widely recognized as a public health crisis, individual, provider, organizational, and policy level barriers impede progress. While many persons with SMI receive most of their care from the public mental health sector, tailored interventions to decrease CVD risk shown effective in clinical trials for those with SMI (e.g., for weight loss, smoking cessation) have not been widely adopted in community mental health settings. Meaningfully advancing health and decreasing mortality disparities for persons with SMI requires urgent development and testing of implementation strategies for scale-up of practical, effective interventions. In response to this extraordinary burden of years of life lost, our goal is to create the Center to Accelerate Translation of Interventions to Decrease Premature Mortality in SMI that will use cutting-edge transdisciplinary methods towards short and long-term progress to reduce CVD risk in this highly vulnerable population. The Center’s uniquely qualified team will conduct 3 R34 studies to develop and pilot test innovative implementation strategies to address all CVD risk behaviors and risk factors in persons with SMI in community mental health settings. The R34s will focus on evidence-based approaches for: 1) behavioral weight loss with diet and physical activity; 2) tobacco smoking cessation treatment; 3) care delivery for diabetes, hypertension and dyslipidemia. The Methods Core will use a transdisciplinary approach incorporating clinical and behavioral intervention research, implementation science, human factors engineering, systems science, and health services research to support Center research. The Methods Core will also advance research methods in 1) human factors engineering to support implementation; 2) avatar-assisted training and assessment in motivational interviewing; 3) quantitative methods to support intervention scale-up; 4) and systems science. The Administrative Core will engage stakeholders, building on well-established partnerships in Maryland and nationally, and bring together all of the Center’s activities. The gaping differential in life expectancy and CVD risk factor burden in persons with SMI calls for concentrated, transdisciplinary approaches to solutions. This Center will create a nexus of innovation and momentum around T2 translation to reduce premature mortality in SMI. Our vision is health equity – that persons with SMI, similar to persons without SMI, live long healthy lives.

患有严重精神疾病的人（SMI）是美国最脆弱的群体之一 死亡10到20年前死亡，死亡率比整体人口高两到三倍。 这种过早死亡的大部分归因于心血管疾病（CVD），并且可以预防。全部 CVD风险行为（不健康的饮食，身体不活跃，吸烟）和危险因素（肥胖， 在患有SMI的人中，高血压，糖尿病和血脂异常明显升高。同时，人 在SMI的情况下，对于这些条件通常会获得较差的护理质量。尽管这些健康和死亡率差距是 被广泛认为是公共卫生危机，个人，提供者，组织和政策层面障碍的阻碍 进步。虽然许多患有SMI的人从公共心理健康部门获得大部分护理，但量身定制 降低CVD风险的干预措施在临床试验中显示出SMI患者有效（例如，减肥， 在社区心理健康环境中，戒烟）尚未被广泛采用。有意义 改善健康状况并减少SMI患者的死亡率差异需要紧急发展和 测试实施策略，以扩大实际，有效的干预措施。 为了回应这种非凡的伯恩（Burnen）多年的生命，我们的目标是创建中心以加速 干预措施的翻译以降低SMI的过早死亡率，这将使用尖端的跨学科 在这个高度脆弱的人群中，短期和长期进步的方法降低了CVD风险。这 Center的独特合格团队将进行3项R34研究，以开发和进行试验测试创新实施 解决社区心理健康中SMI患者中所有CVD风险行为和风险因素的策略 设置。 R34将重点介绍以下循证方法：1）饮食和 体育锻炼； 2）烟草戒烟治疗； 3）护理糖尿病，高血压和 血脂血症。该方法核心将使用跨学科的方法结合了临床和行为 干预研究，实施科学，人为因素工程，系统科学和健康 服务研究以支持中心研究。方法核心还将在1中推进研究方法 人力因素工程以支持实施； 2）阿凡达协助培训和评估 励志面试； 3）支持干预量扩大的定量方法； 4）和系统科学。 行政核心将与利益相关者互动，以马里兰州建立良好合作伙伴关系为基础 在全国范围内，并汇集了所有中心的活动。预期寿命和CVD的差异 SMI呼吁采用集中的，跨学科的解决方案的危险因素燃烧。这 中心将在T2翻译周围建立创新和动力的联系，以减少过早死亡率 smi。我们的愿景是健康公平 - 具有SMI的人，类似于没有SMI的人，过着健康的生活。

项目成果

Commercial Weight Loss Programs in the Management of Obesity: an Update.

• DOI: 10.1007/s13679-021-00428-y
• 发表时间: 2021-06
• 期刊: Current obesity reports
• 影响因子: 8.8
• 作者: Laudenslager M;Chaudhry ZW;Rajagopal S;Clynes S;Gudzune KA
• 通讯作者: Gudzune KA

Agent-Based Modeling for Implementation Research: An Application to Tobacco Smoking Cessation for Persons with Serious Mental Illness.

• DOI: 10.1177/26334895211010664
• 发表时间: 2021-01
• 期刊: Implementation research and practice
• 作者: Huang W;Chang CH;Stuart EA;Daumit GL;Wang NY;McGinty EE;Dickerson FB;Igusa T
• 通讯作者: Igusa T

Physical Activity Levels and Screen Time among Youth with Overweight/Obesity Using Mental Health Services.

• DOI: 10.3390/ijerph19042261
• 发表时间: 2022-02-17
• 期刊: International journal of environmental research and public health
• 作者: Jerome GJ;Fink T;Brady T;Young DR;Dickerson FB;Goldsholl S;Findling RL;Stepanova EA;Scheimann A;Dalcin AT;Terry A;Gennusa J;Cook C;Daumit GL;Wang NY
• 通讯作者: Wang NY

Care Coordination and Population Health Management Strategies and Challenges in a Behavioral Health Home Model.

• DOI: 10.1097/mlr.0000000000001023
• 发表时间: 2019-01
• 期刊: Medical care
• 影响因子: 3
• 作者: Daumit GL;Stone EM;Kennedy-Hendricks A;Choksy S;Marsteller JA;McGinty EE
• 通讯作者: McGinty EE

Evidence-based COVID-19 policy-making in schools.

• DOI: 10.1038/s41591-021-01585-2
• 发表时间: 2021-12
• 期刊: NATURE MEDICINE
• 影响因子: 82.9
• 作者: Stuart, Elizabeth A.;Dowdy, David W.
• 通讯作者: Dowdy, David W.