National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Core Project

全国青少年至成人健康纵向研究（添加健康）：第六波核心项目

基本信息

批准号：
10355540
负责人：
ROBERT A HUMMER
金额：
$ 575.97万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10355540
关键词：
Address Adolescent Adult Age Age-Years Aging Alcoholic Liver Diseases Alcohols Alzheimer&apos s disease related dementia American Ancillary Study Archives Attention Behavior Behavioral Biological Biological Assay Biological Markers Birth Certificates Blood Blood Pressure COVID-19 COVID-19 pandemic Cardiometabolic Disease Cardiovascular Diseases Chronic Cognitive Collection Communities Companions Consent Country Data Data Collection Data Files Death Certificates Dimensions Discrimination Disease Drug abuse Drug usage Economics Elderly Epigenetic Process Ethnic Origin Exhibits Future Gender Gene Expression Genetic Markers Geography Goals Health Health Surveys Heavy Drinking Home Interview Intoxication Life Cycle Stages Link Longitudinal Studies Malignant Neoplasms Measures Mental Health Neighborhoods Online Systems Pain Parents Participant Persons Pharmaceutical Preparations Physical Function Positioning Attribute Reporting Research Personnel Rural Sampling Schools Science Secure Social Change Socioeconomic Status Specimen Stress Substance abuse problem Suicide Venous Visit Work adult obesity base career life balance caregiving cohort cost data dissemination disadvantaged population ethnic minority follow-up health care economics health disparity innovation low socioeconomic status member microbiome middle age mortality pandemic disease psychosocial racial and ethnic racial disparity residence response sexual minority social socioeconomics trend urban residence

项目摘要

Project Summary This project, developed in response to RFA-AG-21-008, describes core plans for data collection and dissemination of the sixth wave (Wave VI) of the National Longitudinal Study of Adolescent to Adult Health (Add Health), when cohort members will be 39-48 years of age (mean 44). Add Health is a longitudinal study of a nationally representative sample of over 20,000 adolescents who were in grades 7-12 during the 1994-95 school year and have been followed for five waves to date. Over 25 years, Add Health has collected rich demographic, social, familial, socioeconomic, behavioral, psychosocial, cognitive, and health survey data from participants and their parents; a vast array of contextual data from participants' schools, neighborhoods, and geographies of residence; administrative data linked to participants, including birth and death certificates; and in-home physical and biological data from participants, including anthropometric measures, genetic markers, blood-based assays, and medications. Ancillary studies have added more information, including epigenetic, gene expression, and microbiome data. Thus, Add Health is exceptionally unique because it has a rich, multi- level, longitudinal array of data for a large nationally representative cohort of Americans who are entering midlife. Importantly, the overall health profile of the cohort as they make the transition to midlife is problematic across many dimensions. Moreover, health disparities by race, ethnicity, gender, socioeconomic status, sexual minority status, and rural-urban residence in this cohort are wide and, in some cases, widening. As such, rich longitudinal, multi-level, and nationally representative data are urgently needed to best understand the life course determinants of health trajectories and health disparities of US adults as they enter midlife. Wave VI of Add Health will fill this critical need. The overall goal of Wave VI of Add Health is to collect and disseminate the comprehensive data needed to best understand the social, economic, psychosocial, contextual, and biological determinants of health trajectories and disparities among this nationally representative cohort of Americans as they age into midlife. The project is focused around five aims: 1) Re-interviewing cohort members using predominantly web-based and in-person modes, with explicit attention to securing high response rates from racial/ethnic minority and low socioeconomic status participants; 2) Enriching study content in key domains that will elucidate mid- and later-life health trajectories and disparities; 3) Re-visiting cohort members who consent for an in-home health exam that includes venous blood collection and other important components of health; 4) Assaying biological specimens for important pre-disease and disease biomarkers; and 5) Cleaning, documenting, disseminating, archiving, promoting, and supporting Wave VI data for the scientific community. This project has extraordinary potential to contribute to the science of aging, health, and health disparities for decades to come, as the Add Health cohort ages into the middle adult years and beyond. Successful carryout of this project will supply essential data for thousands of researchers working on these critical issues.

项目摘要该项目是针对RFA-AG-21-008的响应而开发的，描述了数据收集的核心计划和全国青少年纵向研究的第六波（波VI）传播成人健康（增加健康），当队列成员年龄39-48岁时（平均44岁）。 ADD健康是一项纵向研究在1994 - 95年期间7 - 12年级的20,000多名青少年的全国代表性样本迄今为止，学年已经遵循了五波。 25年来，Add Health收集了丰富的人口，社会，家族，社会经济，行为，社会心理，认知和健康调查数据参与者和他们的父母；来自参与者学校，社区和居住地理；与参与者有关的行政数据，包括出生和死亡证明；和参与者的家庭物理和生物学数据，包括人体测量指标，遗传标记，基于血液的测定和药物。辅助研究添加了更多信息，包括表观遗传学，基因表达和微生物组数据。因此，添加健康是非常独特的，因为它具有丰富的，多的级别，大型国家代表人群的纵向数据阵列中年。重要的是，在过渡到中年时，队列的整体健康状况是有问题的在许多维度上。此外，划分种族，种族，性别，社会经济地位，性行为的健康差异少数群体地位和该队列中的农村居住地很广，在某些情况下会扩大。这样，有钱迫切需要纵向，多层次和全国代表性数据以了解生活美国成年人进入中年时的健康轨迹和健康差异的课程决定因素。波六加上健康将满足这种关键需求。添加健康的波浪VI的总体目标是收集和传播最能理解社会，经济，心理，背景和生物学所需的综合数据国家代表性的美国人队列中的健康轨迹和差异的决定因素他们年龄到中年。该项目围绕五个目标：1）使用主要是基于网络的和面对面的模式，并明确关注从种族/族裔少数民族和社会经济地位低下的参与者； 2）在关键领域中丰富研究内容将阐明中后期的健康轨迹和差异； 3）重新访问同意的队列成员进行家庭健康检查，包括静脉血液的收集和其他重要组成部分； 4）分析重要的预疾病和疾病生物标志物的生物标本； 5）清洁，记录，传播，归档，促进和支持科学界的波VI数据。该项目具有极大的潜力，可以为衰老，健康和健康差异的科学做出贡献即将到来的数十年，随着成年后期及以后的健康队列年龄增加。成功的随身携带该项目将为成千上万的研究人员提供基本数据。