Graduate Training in Cellular and Molecular Pathogenesis of Human Diseases

人类疾病的细胞和分子发病机制研究生培训

• 批准号: 10187600
• 负责人: Zsuzsanna Fabry
• 金额: $ 29.26万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10187600
• 关键词: Molecular; Pathogenesis; Training; human disease

PROJECT SUMMARY/ABSTRACT The Cellular and Molecular Pathology (CMP) Graduate Training Program is a joint venture of the University of Wisconsin (UW)-Madison Graduate School, the Department of Pathology & Laboratory Medicine and the School of Medicine and Public Health (SMPH). CMP provides rigorous didactic training in fundamental basic biomedical sciences combined with interdisciplinary and innovative training in the pathogenesis of major human diseases. The goal of the CMP program is to create a stimulating and robust intellectual environment for predoctoral training embedded in a dynamic basic and clinical translational research atmosphere in order to develop the skills needed to move biological knowledge toward clinical application. Biomedical Graduate Training for the future demands that first rate academic scientists graduate with appropriate operational, technical and professional skills that will position them for diverse bioscience careers in academia, industry or government. The primary mission of the CMP program is to answer this demand and prepare our graduates for productive careers in the rapidly evolving biomedical research field. The program provides operational (in-depth knowledge, rigorous and reproducible experimental design, critical thinking), technical (teaching state-of-the-art methods, rigor and reproducibility) and professional (career development, IDPs and other opportunities) skills to ensure student success. The overall objective of CMP is to educate trainees so that they have a fundamental knowledge of pathology and molecular medicine, and have an in-depth research experience that combines pathobiological and translational clinical research. CMP’s specific objective is to ensure optimal PhD completion rates and time-to-degree with the implementation of monitored IDPs, student success and progress monitoring. CMP objectives will integrate measurable outcomes the program intends to achieve, such as appropriate completion rates, career placement outcomes and student retention rates. The Program draws 85 PhD, MD/PhD or MD funded faculty trainers from 24 departments. We are requesting training of eight pre-doctoral students under the Molecular Medicine Program. Trainees will be supported in the first or second year of their training. Candidates will be selected based on commitment to research documented by research experience, letters of recommendation and the potential to enhance diversity and make significant contributions toward the health-related research needs of our nation. Our curriculum provides interdisciplinary and integrated training in fundamental concepts in modern pathobiology with an emphasis on biochemical, cellular and molecular approaches to the study of human disease, including training in statistics, rigor and reproducibility and responsible conduct in research. CMP helps students to develop teaching and leadership skills through committee service, presentations and workshop teaching. The proposed program provides the fundamental knowledge base, research experience, and understanding of translational clinical research necessary for the success of our graduates.

项目摘要/摘要 细胞和分子病理学（CMP）研究生培训计划是大学的合资企业 威斯康星州（UW） - 病理与实验室医学系麦迪逊研究生院 医学与公共卫生学院（SMPH）。 CMP提供了基本基本的严格教学培训 生物医学科学与主要发病机理中的跨学科和创新训练相结合 人类疾病。 CMP计划的目标是创建一个刺激性稳健的智力环境 用于嵌入动态基础和临床翻译研究气氛中的培训的训练 开发将生物学知识转向临床应用所需的技能。生物医学毕业生 对未来的培训要求一流的学术科学家以适当的运营毕业， 技术和专业技能将使它们适用于学术界的潜水生物科学职业 或政府。 CMP计划的主要任务是回答这一需求并准备我们 快速发展的生物医学研究领域的生产职业毕业生。该程序提供 操作（深入的知识，严格且可重复的实验设计，批判性思维），技术 （教授最先进的方法，严格和可重复性）和专业（职业发展，IDP和IDP和 其他机会）技能以确保学生成功。 CMP的总体目标是教育受训者，因此 他们对病理和分子医学有基本知识，并具有深入的研究 结合病理生物学和翻译的临床研究的经验。 CMP的具体目标是 确保实施受监视的IDP，学生的最佳博士完成率和度量的时间 成功和进度监控。 CMP目标将整合该计划的可衡量结果 达到适当的完成率，职业安排成果和学生保留率。这 计划吸引了来自24个部门的85位博士学位，医学博士/博士学位或MD资助的教师培训师。我们要求 根据Molecular Medicine计划对八名博士前学生的培训。学员将得到支持 他们培训的第一年或第二年。将根据对研究的承诺选择候选人 通过研究经验，推荐信以及增强多样性和 为国家与健康相关的研究需求做出重大贡献。我们的课程提供 现代病理生物学基本概念的跨学科和综合培训，重点是 人类疾病研究的生化，细胞和分子方法，包括统计训练， 严格和可重复性以及研究中负责任的行为。 CMP帮助学生发展教学和 通过委员会服务，演讲和研讨会教学的领导才能。拟议的计划 提供基本的知识库，研究经验以及对翻译临床的理解 我们毕业生成功所必需的研究。