Bioinformatics Core

生物信息学核心

基本信息

批准号：
9981784
负责人：
JASON L BURKHEAD
金额：
$ 31.31万
依托单位：
UNIVERSITY OF ALASKA FAIRBANKS
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-24 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9981784
关键词：
Address Alaska Alaska Native Alaskan Animals Award Bioinformatics Biomedical Research Biometry Clinical Research Collaborations Communities Consultations Data Analyses Development Ecology Educational Curriculum Educational workshop Enhancement Technology Environment Equipment Experimental Designs Faculty Family Foundations Funding Gene Proteins Goals Health High Performance Computing Human Individual Infrastructure Institutes Interdisciplinary Study Investments Leadership Methodology Methods Microbe Modeling Modernization Native-Born Personal Satisfaction Plants Postdoctoral Fellow Proteomics Research Research Infrastructure Research Personnel Resource Sharing Resources Scientist Services Structure Students System Technology Training Training and Education Translational Research Travel United States National Institutes of Health Universities base behavioral health bioinformatics resource career career development curriculum development data acquisition experience genome resource health disparity health organization instrumentation nanopore next generation sequencing programs protein metabolite recruit student training tool tribal health

项目摘要

Alaska INBRE 4 - BIOINFORMATICS CORE PROJECT SUMMARY One Health recognizes that human health is connected to the health of animals and their shared environment. These relationships in modern biomedical research enable researchers to study people, animals, plants, and microbes and their interactions through multiple bottom-up “omics” methods. The results include massive amounts of information about genes, proteins, and metabolites in an experimental system, which represents a revolutionary technological advancement in biomedical research that also necessitates new tools to sort and analyze the information. The AK INBRE 3 Bioinformatics Core established a distributed core model where Alaska-based bioinformatics resources were augmented by support for access to external resources and training from outside the University of Alaska network. The overall goals of the AK INBRE 4 Bioinformatics Core are to provide state-of-the art services and training in bioinformatics and biostatistics for investigators and students. The core will build on the successful AK INBRE 3 Core by providing enhanced support for Alaska infrastructure, including massively-parallel “next-gen” sequencing and high performance computing, as well as by promoting development of emerging bioinformatics technologies in the Alaska user group. Core activities will leverage bioinformatics resources within the UA system and provide funding and guidance to investigators to capitalize on external bioinformatics resources to build biomedical research capacity in Alaska. The Core deploys a distributed model that leverages Alaska-based resources in high-performance computing, next-gen sequencing, and biostatistics with funding support for AK INBRE scientists to use external resources and training. With an overall goal to provide state-of-the art services and training for bioinformatics and biostatistics for the AK INBRE community, the core will execute the following specific aims: 1) Provide access to bioinformatics technology and data acquisition through the support of local equipment and expertise as well as access to resources outside of Alaska; 2) Support bioinformatics and biostatistics experimental design and data analysis through access to specialized Alaska-based and external expertise; 3) Support career development and bioinformatics training for students, postdoctoral fellows, faculty and senior researchers in the AK INBRE network through Alaska-based workshops and curriculum development, as well as through support for external training; 4) Promote the development of emerging bioinformatics technologies that enhance INBRE One Health research.

阿拉斯加 INBRE 4 - 生物信息学核心项目摘要 One Health 认识到人类健康与动物及其共同环境的健康息息相关。现代生物医学研究中的这些关系使研究人员能够研究人、动物、植物和通过多种自下而上的“组学”方法研究微生物及其相互作用，结果包括大量的结果。实验系统中有关基因、蛋白质和代谢物的大量信息，代表了生物医学研究中革命性的技术进步也需要新的工具来分类和 AK INBRE 3 生物信息学核心建立了一个分布式核心模型，其中通过支持获取外部资源和资源，阿拉斯加的生物信息学资源得到了增强。来自阿拉斯加大学网络外部的培训 AK INBRE 4 生物信息学的总体目标。核心是为研究人员和生物统计学提供最先进的服务和生物信息学和生物统计学培训该核心将以成功的 AK INBRE 3 核心为基础，为阿拉斯加提供增强的支持。基础设施，包括大规模并行“下一代”测序和高性能计算，以及通过促进阿拉斯加用户组核心活动中新兴生物信息学技术的发展。将利用 UA 系统内的生物信息学资源，为研究人员提供资金和指导利用外部生物信息学资源来建设阿拉斯加核心的生物医学研究能力。部署分布式模型，利用阿拉斯加的高性能计算、下一代资源测序和生物统计学，为 AK INBRE 科学家提供资金支持，以利用外部资源和培训的总体目标是提供最先进的生物信息学和生物统计学服务和培训。对于 AK INBRE 社区，核心将执行以下具体目标： 1) 提供对通过本地设备和专业知识的支持以及生物信息学技术和数据采集获取阿拉斯加以外的资源；2) 支持生物信息学和生物统计学实验设计和通过获取阿拉斯加的专业知识和外部专业知识进行数据分析 3) 支持职业；为学生、博士后、教师和高级研究人员提供发展和生物信息学培训 AK INBRE 网络通过阿拉斯加的研讨会和课程开发，以及通过支持外部培训；4）促进新兴生物信息学技术的发展加强 INBRE One Health 研究。