APOLLO - Upper Midwest

阿波罗 - 上中西部

基本信息

批准号：
9977188
负责人：
Brad C Astor
金额：
$ 34.11万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9977188
关键词：
APOL1 gene Acute African African American Apolipoproteins Caregivers Caring Chronic Kidney Failure Clinical Data Decision Making Disease Donor person End stage renal failure Epidemiology Event Fibrinogen Genes Genetic Genotype Goals Graft Survival Hospitals Incidence Individual Intervention Investigation Kidney Kidney Failure Kidney Transplantation Living Donors Midwestern United States Monitor Nephrology Organ Organ Donor Organ Procurements Organ Transplantation Outcome Population Precipitating Factors Proteinuria Public Health Relative Risks Renal function Research Research Personnel Risk Risk Factors Socioeconomic Factors Transplant Recipients Transplantation Transplantation Surgery Universities Variant Wisconsin base clinical risk clinically significant delayed graft function genetic variant graft failure graft function high risk living kidney donor mortality risk variant transplant centers

项目摘要

ABSTRACT Recipients of a kidney transplant from an African-American deceased donor have worse outcomes than their counterparts receiving an organ from a White deceased donor. The extent to which this is due to the presence of high-risk APOL1 genotypes in African-American donors is unknown. Several recent studies have found a positive association between high-risk APOL1 genotypes and graft failure, but these have been based on relatively few events, have come primarily from a few large centers, and have not analyzed donor-recipient pairs. The proposed studies will investigate the association of a kidney donor's APOL1 status with recipient outcomes. We will also study estimate the impact of APLO1 status on living donor outcomes. We have assembled a consortium including 6 organ procurement organizations covering 7 states in the Upper Midwest, 123 recovering hospitals, 25 transplant centers and collaborators in transplant surgery, transplant nephrology, epidemiology and genetics to achieve these goals. These findings will provide a greater understanding of the impact of the presence of high-risk APOL1 variants in both recipients and living donors. These data are needed for informed decision-making for recipients, potential living donors, and their caregivers. Both the relative and absolute risk of clinically significant events associated with high-risk APOL1 variants will be estimated with much greater precision that previous studies, allowing more informed decisions on acceptance of specific organs for transplantation.

抽象的来自非裔美国人死者捐助者的肾脏移植的接受者的情况更糟结果比他们的同行从白人死者的捐助者那里接收器官。程度这是由于非裔美国人捐助者中存在高风险APOL1基因型的原因是未知。最近的一些研究发现高风险Apol1之间存在正相关基因型和移植失败，但这些都是基于相对较少的事件的，已经来了主要来自几个大中心，尚未分析供体 - 接收对。提议研究将调查肾脏供体的APOL1状态与接受者的关联结果。我们还将研究估计Aplo1状态对活捐助者结果的影响。我们组建了一个财团，包括6个器官采购组织7 中西部上部的州，123家恢复医院，25个移植中心和合作者在移植手术中，移植肾脏病，流行病学和遗传学以实现这些目标。这些发现将对高风险存在的影响有更深入的了解接收者和活捐赠者的Apol1变体。这些数据需要知情为接收者，潜在的捐助者及其照顾者进行决策。亲戚和与高风险APOL1变体相关的临床意义事件的绝对风险将是估计以比以前的研究更高的精确度，从而允许更明智的决定接受特定器官进行移植。