Center for Prevention Implementation Methodology for Drug Abuse and HIV (Ce-PIM) - Innovative Implementation Methods Core for HIV and Drug Abuse

药物滥用和艾滋病毒预防实施方法中心 (Ce-PIM) - 艾滋病毒和药物滥用的创新实施方法核心

• 批准号: 9975814
• 负责人: C. HENDRICKS BROWN
• 金额: $ 64.04万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9975814
• 关键词: AIDS prevention; Abnormal coordination; Address; Adoption; Affect; African American; Benchmarking; Biology; Communities; Community Healthcare; Complex; Contracts; Decision Making; Development; Discipline; Drug abuse; Effectiveness; Engineering; Evidence based intervention; Evidence based practice; Failure; Funding; Government; Grant; HIV; HIV Infections; HIV Seropositivity; Hand; Health; Home environment; Homelessness; Human immunodeficiency virus test; Incidence; Individual; Information Systems; Intervention; Jail; Knowledge; Latino; Learning; Measurement; Measures; Mentors; Methodology; Methods; Minority Groups; Modeling; Municipalities; National Institute of Drug Abuse; Persons; Pharmaceutical Preparations; Play; Policies; Population; Prevention; Prevention program; Property; Public Health; Publishing; Qualifying; Research; Research Personnel; Resources; Rest; Risk; Science; Services; Sexual Health; Substance abuse problem; System; Testing; Time; Training; United States Substance Abuse and Mental Health Services Administration; Virus; Work; antiretroviral therapy; base; care seeking; career; design; drug abuse prevention; ethnic minority population; health care delivery; high risk; high risk sexual behavior; implementation research; implementation science; implementation strategy; implementation trial; improved; innovation; men; men who have sex with men; metropolitan; models and simulation; novel; pre-exposure prophylaxis; prevent; programs; racial and ethnic; ranpirnase; routine practice; scale up; sexual HIV transmission; social determinants; success; tool; transmission process; uptake; young men who have sex with men

PROJECT SUMMARY/ABSTRACT This application is for a competing renewal of the Center for Prevention Implementation Methodology for HIV and Drug Abuse, a NIDA P30 Center of Excellence. The number of new HIV cases in the US remains stable at 56,000 per year and continues to disproportionately affect some groups, including young men who have sex with men (YMSM), especially from racial/ethnic minorities. The purpose of this methodology center is to develop new methodologies that can be used by federal and local agencies and communities to reduce HIV incidence. Biomedical interventions and strategies, including pre-exposure prophylaxis (PrEP), rapid testing for HIV and early and consistent treatment for persons who are HIV positive (Treatment as Prevention, TasP) have been shown to have high efficacy and effectiveness in reducing HIV transmission, but there remains a giant gap between what research knows and what services needed to reduce population level incidence of HIV. The major premise of this application is that the effective biomedical to reduce HIV incidence and disparities are in hand, but success will only be achieved when they are implemented in ways that meet individual, community, and health care delivery system needs. This methods proposal addresses this major gap between research and practice through implementation science and methodology, focusing on innovative ways to address the complex, mulitilevel interactions needed to implement HIV prevention programs effectively. Two Cores, an Administrative Core and an Innovative Implementation Methods Core for HIV and Drug Abuse will carry out this work. Aim 1 is to develop innovative methods to maximize the impact of implementation research in HIV prevention. We do this through an extended set of systems science and engineering methods that focus on improving the measurement of implementation, the modeling of implementation strategies, and the testing of implementation strategies through rigorous trials. Five qualifying grants support this work. Aim 2 is to apply these innovative methods to close the gap between existing research, policy, and practice for HIV prevention. In addition to working closely with our five qualifying grants, we work locally with municipal Departments of Public Health and the federal Substance Abuse and Mental Health Services Administration (SAMHSA) HIV programs to identify and prioritize gaps in knowledge, find optimal implementation strategies for reduction of HIV transmission, and design the next large implementation trials. Aim 3 is to disseminate methods and train/mentor leaders at the intersection of HIV prevention, implementation science, and drug abuse fields to improve implementation of HIV prevention programs. This involves mentoring the early career researchers, publishing, and providing training to networks of HIV and drug abuse researchers.

项目概要/摘要 本申请用于预防中心实施方法的竞争性更新 艾滋病毒和药物滥用，NIDA P30 卓越中心。美国新增艾滋病毒病例数 稳定在每年 56,000 人，并继续对包括年轻人在内的一些群体产生不成比例的影响 男男性行为者 (YMSM)，尤其是少数族裔/族裔。这样做的目的 方法论中心致力于开发可供联邦和地方机构使用的新方法 社区减少艾滋病毒发病率。生物医学干预措施和策略，包括暴露前 预防 (PrEP)、艾滋病毒快速检测以及艾滋病毒感染者的早期和持续治疗 积极的（治疗即预防，TasP）已被证明在以下方面具有高效能和有效性： 减少艾滋病毒传播，但研究成果与服务之间仍存在巨大差距 需要降低人口水平的艾滋病毒发病率。该应用的大前提是 减少艾滋病毒发病率的有效生物医学手段和差距已在眼前，但成功只能靠 当它们以满足个人、社区和医疗保健提供的方式实施时即可实现 系统需求。该方法提案通过以下方式解决了研究与实践之间的主要差距 实施科学和方法论，重点关注解决复杂问题的创新方法， 有效实施艾滋病毒预防计划需要多层次的互动。两个核心，一个 艾滋病毒和药物滥用的行政核心和创新实施方法核心将开展 这项工作。 目标 1 是开发创新方法，最大限度地发挥实施研究的影响 艾滋病毒预防。我们通过一套扩展的系统科学和工程方法来做到这一点 重点关注改进实施的衡量、实施策略的建模以及 通过严格的试验来测试实施策略。五项合格赠款支持这项工作。 目标 2 是应用这些创新方法来缩小现有研究、政策和技术之间的差距 预防艾滋病毒的实践。除了与我们的五项合格赠款密切合作外，我们还与当地合作 市公共卫生部门和联邦药物滥用和心理健康部门 服务管理局 (SAMHSA) 艾滋病毒计划，旨在确定知识差距并确定优先顺序， 找到减少艾滋病毒传播的最佳实施策略，并设计下一个大型计划 实施试验。 目标 3 是传播艾滋病毒交叉点的方法并培训/指导领导者 预防、实施科学和药物滥用领域，以改善艾滋病毒预防的实施 程序。这包括指导早期职业研究人员、出版以及为网络提供培训 艾滋病毒和药物滥用研究人员。