SPECT/CT for Molecular Imaging Facility at TJU

TJU 分子成像设备 SPECT/CT

• 批准号: 8628246
• 负责人: MATHEW laxman THAKUR
• 金额: $ 30.04万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-27 至 2015-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8628246
• 关键词: 4 year old; Animals; Basic Science; Biomedical Research; Cardiology; Cost Control; Data; Diagnosis; Disease; Docking; Doctor of Philosophy; Drug Kinetics; Effectiveness; Enrollment; Equipment; Funding; Image; Imaging Device; Investigation; Journals; Letters; Magnetic Resonance Imaging; Modality; Neurology; Optics; Peer Review; Physicians; Positron-Emission Tomography; Prevention; Radiology Specialty; Research Personnel; Research Project Grants; Resolution; Scientist; Services; System; Therapeutic Intervention; Translational Research; Ultrasonography; in vivo; molecular imaging; novel; oncology; operation; optical imaging; single photon emission computed tomography

DESCRIPTION (provided by applicant): The importance of imaging small animals in basic and translational biomedical research, with such modalities as PET, SPECT, CT, optical, ultrasound and MRI, cannot be overemphasized. The ability to image small animals without having to sacrifice a large number of them allows investigators to a) validate novel probes for diagnosis and therapy, b) conduct pharmacokinetic studies in vivo, c) evaluate investigational bio- molecules for prevention and treatment of diseases, and d) determine the effectiveness of therapeutic interventions. Small animal imaging reduces the number of animals to be enrolled in each investigation, controls cost, and provides valuable, scientifically valid data that can be evaluated statistically. At TJU, more than three hundred basic and physician scientists are engaged in biomedical research in oncology, neurology and cardiology. In 2004, TJU established a small animal imaging facility that is directed by the PI (Mathew L. Thakur, PhD), in the Department of Radiology. The facility includes a CT, PET/SPECT, a PET scanner and an optical imaging device. This facility has thus far been used by thirty-seven investigators and produced sixty four articles in peer-reviewed journals. CT is an integral part of PET/SPECT imaging. The four-year-old MicroCAT II CT we are currently using breaks down frequently. Even worse, Siemens service is not available as of January 1, 2012 (letter dated August 1, 2011). Our SPECT equipment is a modified Philips MOSAIC PET unit that suffers from poor resolution and presents numerous technical challenges for its operation in the SPECT mode. The availability of the Siemens SPECT/CT unit that can dock to our existing Siemens Inveon PET will provide us with a highly versatile, integrated, tri-modal imaging system that shall greatly enhance our imaging capability and serve for several federally funded translational and basic research projects at TJU. No such system currently exists at TJU. (1)

描述（由申请人提供）：使用 PET、SPECT、CT、光学、超声和 MRI 等方式对小动物进行成像在基础和转化生物医学研究中的重要性怎么强调也不为过。无需牺牲大量动物即可对小动物进行成像的能力使研究人员能够a）验证用于诊断和治疗的新型探针，b）进行体内药代动力学研究，c）评估用于预防和治疗疾病的研究生物分子， d) 确定治疗干预措施的有效性。小动物成像减少了每次研究中招募的动物数量，控制了成本，并提供了可进行统计评估的有价值的、科学有效的数据。在天津大学，三百多名基础科学家和医学科学家从事肿瘤学、神经病学和心脏病学的生物医学研究。 2004 年，天津大学在放射科建立了一个小动物成像设施，由 PI（Mathew L. Thakur 博士）领导。该设施包括 CT、PET/SPECT、PET 扫描仪和光学成像设备。迄今为止，该设施已被 37 名研究人员使用，并在同行评审期刊上发表了 64 篇文章。 CT 是 PET/SPECT 成像的一个组成部分。我们目前使用的 MicroCAT II CT 使用了四年，经常出现故障。更糟糕的是，自 2012 年 1 月 1 日起，西门子服务不再可用（日期为 2011 年 8 月 1 日的信件）。我们的 SPECT 设备是经过改进的飞利浦 MOSAIC PET 装置，其分辨率较差，并且在 SPECT 模式下运行存在许多技术挑战。西门子 SPECT/CT 设备可与我们现有的西门子 Inveon PET 对接，将为我们提供高度通用、集成的三模态成像系统，该系统将大大增强我们的成像能力，并为多项联邦政府资助的转化和基础研究服务天津大学的项目。 TJU 目前没有这样的系统。 (1)