Risk of Parkinson Disease Associated with Solvent Exposures in Finland

芬兰与溶剂接触相关的帕金森病风险

• 批准号: 8752056
• 负责人: Brad A Racette
• 金额: $ 22.21万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-25 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8752056
• 关键词: Age; Age of Onset; Aromatic Hydrocarbons; Benzene; Case-Control Studies; Censuses; Chlorinated Hydrocarbons; Collaborations; Comorbidity; Comprehensive Health Care; Coronary heart disease; Country; Data; Databases; Dementia; Disease; Disease Progression; Elderly; Emergency Situation; Environmental Air Pollutants; Epidemiologic Studies; Evaluation; Exposure to; Finland; Healthcare; Hip Fractures; Hydrocarbons; Immigration; Individual; Institutes; Institution; Link; Malignant Neoplasms; Mechanics; Mental Depression; Metals; Methylene Chloride; Morbidity - disease rate; Neurodegenerative Disorders; Neurologist; Occupational; Occupational Epidemiology; Occupational Exposure; Occupational Health; Occupations; Onset of illness; Organic solvent product; Parkinson Disease; Parkinsonian Disorders; Pensions; Persons; Pharmacotherapy; Phenotype; Plastics; Population; Prevention; Psychotic Disorders; Public Health; Public Policy; Records; Registries; Relative Risks; Research Personnel; Risk; Risk Factors; Solvents; Symptoms; Tetrachloroethylene; Toluene; Trichloroethanes; Trichloroethylene; Universities; Washington; Water Pollutants; Work; cohort; comparison group; compliance behavior; disease diagnosis; disorder risk; falls; migration; mortality; neuropsychiatry; neurotoxic; population based; population health; public health relevance; sex; treatment planning; urban area

DESCRIPTION (provided by applicant): Parkinson disease (PD) is a common disease of the elderly associated with substantial morbidity and early mortality. The causes of PD are largely unknown, but recent studies in small cohorts have implicated occupational exposure to neurotoxic solvents. Demonstrating a relation in a larger study would provide an opportunity to reduce exposures and hence disease risk. This is particularly important given the lack of any definitive pharmacotherapy to slow disease progression. Moreover, prevention would not be limited to workers with high exposures such as painters, mechanics, metal workers and plastic workers, since solvents are common environmental air and water pollutants in urban areas of the US. This proposal investigates the relation between occupational solvent exposure and incident PD in a large and efficiently-constructed, population-based study using existing data in Finland. Finland is an ideal country in which to conduct the studies described below due to low migration/immigration, universal health care, PD diagnoses made by neurologists, and high patient compliance with treatment plans. For this study, we will link the Finnish national population registry to the national comprehensive health care database to identify incident PD cases and a highly suitable comparison group, along with a wealth of covariate data for all subjects. We will further link these data with individual-level occupational data from the Finnish census and national pension database, and then estimate occupational solvent exposure, using the validated Finnish Job-Exposure Matrix (FINJEM). These Finnish databases have been used extensively to investigate occupational risk factors for many other diseases, including cancer and coronary heart disease, but remain to be used to investigate occupational risks associated with PD or other neurodegenerative diseases. The investigators and institutions in this proposal are ideally suited to perform the proposed study, representing the leading occupational health experts from the Finnish Institute of Occupational Health (FIOH) and well-established occupational epidemiology research collaboration between Washington University and the University of Washington.

描述（由申请人提供）：帕金森病（PD）是一种老年人常见疾病，发病率高，死亡率高。帕金森病的病因在很大程度上尚不清楚，但最近的小规模研究表明，职业性接触神经毒性溶剂有关。在更大规模的研究中证明这种关系将为减少暴露和疾病风险提供机会。鉴于缺乏任何确定的药物疗法来减缓疾病进展，这一点尤其重要。此外，预防措施不仅限于油漆工、机械师、金属工人和塑料工人等高接触溶剂的工人，因为溶剂是美国城市地区常见的环境空气和水污染物。该提案利用芬兰的现有数据，在一项大型、高效、基于人群的研究中调查了职业溶剂暴露与局部放电事件之间的关系。由于移民/移民率低、全民医疗保健、神经科医生做出的帕金森病诊断以及患者对治疗计划的高度依从性，芬兰是进行下述研究的理想国家。在这项研究中，我们将芬兰国家人口登记处与国家综合医疗保健数据库联系起来，以识别帕金森病事件病例和高度合适的对照组，以及所有受试者的大量协变量数据。我们将进一步将这些数据与芬兰人口普查和国家养老金数据库中的个人职业数据联系起来，然后使用经过验证的芬兰工作暴露矩阵（FINJEM）来估计职业溶剂暴露。这些芬兰数据库已广泛用于调查许多其他疾病的职业风险因素，包括癌症和冠心病，但仍有待用于调查与帕金森病或其他神经退行性疾病相关的职业风险。本提案中的研究人员和机构非常适合开展拟议的研究，他们代表了芬兰职业健康研究所 (FIOH) 的领先职业健康专家以及华盛顿大学和华盛顿大学之间完善的职业流行病学研究合作。