University of Utah Interdisciplinary Training Program in Computational Approaches to Diabetes and Metabolism Research

犹他大学糖尿病和代谢研究计算方法跨学科培训项目

• 批准号: 9930879
• 负责人: Karen Louise Eilbeck
• 金额: $ 2.46万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9930879
• 关键词: Diabetes Mellitus; Metabolism; Research; Training Programs; Universities; Utah

PROJECT SUMMARY There is a broad consensus that obesity, diabetes, and its many complications represent one of the major public health crises of the 21st century in the United States and globally. Biomedical research efforts aimed at characterization of the etiology, diagnoses, prognosis, and outcomes of diabetes has increasingly generated large amounts of complex data in many scientific fields including structural biology, informatics, metabolomics, whole genome sequencing, proteomics, phenotypic datasets, electronic health records, and public health datasets. Computational and mathematical methods in bioinformatics, clinical informatics, data visualization, and mathematical modeling are needed to analyze and interpret the plethora of data to improve the lives of people with diabetes. With unique resources such as the Utah Population Database, the Utah Genome Project, the Department of Biomedical Informatics, and Utah's Diabetes and Metabolism Center, the University of Utah has an exceptional training environment and has seen many dual-mentored trainees establish independent research careers. In this application we propose to formally establish an NIDDK Interdisciplinary Training Program in Computational Approaches to Diabetes and Metabolism Research at the University of Utah under the leadership of Wendy Chapman, PhD, Chair of the Department of Biomedical Informatics, and Simon Fisher, MD, PhD, Chief of the Division of Endocrinology and Co-Director of the Diabetes and Metabolism Center at the University of Utah. The proposed multidisciplinary training program spans 18 departments at the University. The goal of this interdisciplinary program is to prepare predoctoral and postdoctoral trainees to be leaders in computational and mathematical methods and engage them in the analysis of large data sets involving complex biological problems in diabetes, obesity, and metabolism. Each trainee will participate in a two-year training program that includes a research project with a multidisciplinary mentoring committee, didactic coursework, and professional development opportunities. Each trainee will receive dual mentorship from both a computational and a biological mentor. The mentoring committees, tailored to each trainee's research interests, will draw from a mentor pool of 55 MD and PhD investigators (26 computational/mathematic mentors and 29 diabetes/metabolism mentors). The training program will be overseen by an executive committee comprising the two Principal Investigators and five Co-Directors, all of whom are investigators with strong track records of uncompromising commitment to mentoring trainees. We are requesting support for five trainee positions (three predoctoral and two postdoctoral) to train a total of 12 scientists over 5 years. With this unique interdisciplinary training experience, we expect our trainees to become world leaders in the application of bioinformatics to diabetes, obesity, and metabolism research.

项目摘要 有一个广泛的共识，肥胖，糖尿病及其许多并发症代表了主要的并发症之一 21世纪和全球的21世纪公共卫生危机。生物医学研究工作旨在 糖尿病的病因，诊断，预后和结局的表征增加了 许多科学领域的大量复杂数据，包括结构生物学，信息信息，代谢组学， 整个基因组测序，蛋白质组学，表型数据集，电子健康记录和公共卫生 数据集。生物信息学，临床信息，数据可视化的计算和数学方法， 需要数学建模来分析和解释大量数据以改善 患有糖尿病的人。凭借独特的资源，例如犹他州人口数据库，犹他州基因组项目， 生物医学信息学系以及犹他州的糖尿病和代谢中心，犹他大学 有一个非凡的培训环境，并且已经看到许多双人训练的学员建立了独立 研究事业。在此应用程序中，我们建议正式建立NIDDK跨学科培训 犹他大学的糖尿病和代谢研究计算方法计划 生物医学信息学系主任的温迪·查普曼（Wendy Chapman）领导，西蒙 费舍尔，医学博士，博士，内分泌学系负责人和糖尿病和代谢联合主任 犹他大学中心。拟议的多学科培训计划跨越了18个部门 大学。该跨学科计划的目的是准备前学生和博士后学员 计算和数学方法的领导者，并让他们参与大型数据集的分析 在糖尿病，肥胖和代谢中涉及复杂的生物学问题。每个学员将参加 为期两年的培训计划，其中包括由多学科指导委员会的研究项目， 教学课程和专业发展机会。每个学员将获得双重指导 来自计算和生物学精神。为每个学员量身定制的心理委员会 研究兴趣将从55 MD和博士学位研究人员的精神库中汲取（26个计算/数学 导师和29名糖尿病/代谢导师）。培训计划将由高管监督 委员会涉及两个主要调查员和五个联合主席，他们都是 对心理学员的毫不妥协的承诺的强有力记录。我们要求支持五个 在5年内，学员的职位（三个占三个占主导地位和两个博士后）在总共培训了12位科学家。与此 独特的跨学科培训经验，我们希望我们的学员成为申请中的世界领导者 糖尿病，肥胖和代谢研究的生物信息学研究。