Resource Dissemination and Outreach Center for Illuminating the Druggable Genome

阐明可药物基因组的资源传播和外展中心

• 批准号: 9932594
• 负责人: TUDOR I OPREA
• 金额: $ 19.61万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9932594
• 关键词: Access to Information; Biological; Biology; Communities; Data; Development; Disease; Drug Targeting; Family; G-Protein-Coupled Receptors; Genome; Human; Infrastructure; Ion Channel; Lighting; Medical; New Mexico; Pharmaceutical Preparations; Policies; Process; Protein Kinase; Proteins; Proteome; Reagent; Reproducibility; Research; Research Personnel; Resources; TimeLine; Training; Training Programs; United States National Institutes of Health; Universities; Work; clinical development; data resource; drug discovery; experience; improved; interoperability; member; novel; novel therapeutics; operation; outreach; outreach program; pre-clinical; programs; success; tool

PROJECT SUMMARY Despite steady progress in developing novel therapeutics and their enormous medical and societal benefits, current drugs target only a small fraction of the human proteome. Even drugs in clinical development and most preclinical drug discovery research ignore a significant portion of the druggable proteome. Through the development, broad dissemination, and use of community scientific resources, the IDG program is focused on advancing research to study human proteins for which publicly available information or active research is currently lacking, in order to catalyze the discovery of novel biology with a particular focus on understudied members of the protein kinase, ion channel, and non-olfactory GPCR families. Our highly-coordinated team from the University of New Mexico and the University of Miami has established the IDG generated relationships The IDG-RDOC works with all IDG Consortium investigators to collect and curate information regarding critical tools and reagents being developed by the IDG Consortium and disseminate them through the IDG Portal. Specifically we: (i) coordinate and support the IDG consortium via a highly experienced administrative team; (ii) facilitate and coordinate external partnerships, outreach, and training related to IDG program activities; and (iii) develop and implement data standards, policies, operations, and tools to collect, curate, identify, and disseminate IDG-generated resources in accordance with (extended) NIH FAIR (Findable, Accessible, Attributable, Interoperable, Reusable, Reproducible) principles. Via the proposed supplement, we will significantly expand the capabilities of the RDOC as requested by the NIH program, but not originally proposed due to budgetary constraints. In particular we will implement and support a dynamic Protein Illumination Timeline (PIT) and required infrastructure and processes as a primary mechanism of communicating progress of the consortium regarding the illumination of understudied proteins and to provide access to information of IDG-generated resources related to understudied proteins. Resource Dissemination and Outreach Center (RDOC) to facilitate widespread access to consortium- data and resources as well as to serve the overall administration of the IDG Consortium and its with external partners. 1

项目摘要 尽管在发展新型治疗剂及其巨大的医学和社会利益方面取得了稳步的进展，但 当前药物仅针对人类蛋白质组的一小部分。甚至临床开发中的药物，大多数药物 临床前药物发现研究忽略了可鉴定蛋白质组的很大一部分。通过 IDG计划的开发，广泛的传播和社区科学资源的使用是 研究研究人类蛋白质的研究，该蛋白是公开可用信息或主动研究的研究 目前缺乏，为了催化新的生物学发现，特别关注研究 蛋白激酶，离子通道和非富尔科GPCR家族的成员。 我们来自新墨西哥大学和迈阿密大学的高度协调的团队已建立 IDG 生成 关系IDG-RDOC与所有IDG财团调查员合作收集和 关于IDG财团开发的关键工具和试剂的策划信息， 通过IDG门户将它们传播。具体我们：（i）通过A协调和支持IDG财团 经验丰富的行政团队； （ii）促进和协调外部伙伴关系，外展和 与IDG计划活动有关的培训； （iii）制定和实施数据标准，政策，操作， 以及根据（扩展）收集，策划，识别和传播IDG生成的资源的工具 NIH Fair（可访问，可访问，可归因，可互操作，可重复使用，可重现）原则。 通过拟议的补充，我们将按照拟议的补充剂大大扩展RDOC的功能 NIH计划，但最初不是由于预算限制而提出的。特别是我们将实施和 支持动态蛋白照明时间表（PIT），并作为主要基础架构和过程 有关研究蛋白的照明的财团进步的机制 并提供与已研究蛋白质有关的IDG生成资源的信息。 资源传播与外展中心（RDOC），以促进广泛进入财团的机会 数据和资源以及为IDG财团及其的整体管理服务 与外部合作伙伴。 1