Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer Disease Risk

多元文化健康饮食可减少认知能力下降

• 批准号: 9925720
• 负责人: Yasmin Mossavar-Rahmani
• 金额: $ 79.56万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925720
• 关键词: Adult; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; American; Anti-Inflammatory Agents; Biological Markers; C-reactive protein; Caring; Carotenoids; Cellular Phone; Chronic Disease; Clinical Trials; Cognition; Cognitive; Cognitive aging; Consumption; Cultural Diversity; DASH diet; Dementia; Diet; Dietary Intervention; Dietary Practices; Direct Costs; Disease; Dominican; Eating; Elderly; F2-Isoprostanes; Fatty Acids; Folic Acid; Fruit; Health; Hispanic Community Health Study/Study of Latinos; Hispanics; Impaired cognition; Incidence; Income; Individual; Inflammatory; Interleukin-6; Intervention; Measurable; Measurement; Measures; Methodology; Methods; Minority; Nerve Degeneration; Neurocognitive; New York; Observational Study; Oxidative Stress; Participant; Patient Self-Report; Pattern; Pilot Projects; Population; Population Heterogeneity; Psyche structure; Puerto Rican; Randomized; Randomized Clinical Trials; Savings; Serum; Short-Term Memory; Testing; Time; Tocopherols; Urban Population; Vegetables; Vitamin B 12; aging population; arm; base; care costs; cognitive benefits; cognitive change; cognitive function; cohort; cost; cost estimate; design; falls; follow-up; good diet; high risk; improved; indexing; inflammatory marker; lifestyle factors; mental function; middle age; novel; post intervention; prevent; processing speed; treatment arm; two-arm study; urban setting

Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer Disease Risk We propose a randomized clinical trial to investigate whether the Multicultural Healthy Diet (MHD), an anti-Inflammatory diet based on the Dietary Inflammatory Index tailored to a multi- cultural population, can improve cognitive functioning in a middle aged (40-65 yr old) urban population in Bronx, New York compared to a usual diet. We propose this study starting in a middle-aged population because early indicators of cognitive aging may manifest long before old age. Many previous studies have also used global mental function tests and relied on designs with relatively few and widely spaced repeated measurements, both of which can compromise the ability to detect cognitive change. To overcome these limitations, we propose to assess dietary effects on cognition using a “measurement-burst” design, which will consist of administering 35 brief assessments of a broad range of cognitive functions using smartphones during week-long measurement-bursts at nine-month intervals and repeated three times. This intensive measurement approach allows assessment of cognitive function in “real-time” which can provide a more reliable index of function that is more sensitive to change. The aims of this proposal are to: A1. Show that the MHD can be adapted to a diverse middle-aged cohort in the Bronx. Evaluate pre- and post-intervention serum biomarkers indicative of a MHD diet pattern, specifically total folate & vitamers, tocopherols, carotenoids, vitamin B12 and fatty acid profile; and self-reported intake of food groups such as fruits and green leafy vegetables, to compare study arms. A2. Test whether a MHD intervention in a multi-ethnic urban setting can benefit cognitive function in a middle-aged population. Assess cognitive functions (spatial working memory, short term memory, self-reported mental sharpness, processing speed), using real-time ambulatory assessments over a 7-day period every 9 months to evaluate the time course over which positive impacts are detectable. A3. Identify components of the MHD diet that are associated with stable or improved measures of cognition. We will evaluate biomarkers indicative of a MHD diet pattern (see A1) and relate to cognitive function measures.

多元文化健康饮食以减少认知能力下降和阿尔茨海默氏病风险 我们提出了一项随机临床试验，以调查多元文化健康饮食是否 （MHD），一种基于饮食炎症指数的抗炎饮食 文化人口可以改善中年（40 - 65岁）的城市的认知功能 与通常的饮食相比，纽约布朗克斯的人口。我们提出了这项研究。 中年人口是因为认知衰老的早期指标可能很早就表现出来 晚年。许多先前的研究还使用了全球心理功能测试并退休了 设计相对较少且间距广泛的重复测量值，这两者都可以 损害检测认知变化的能力。为了克服这些限制，我们建议 使用“测量 - 燃烧”设计评估对认知的饮食影响，该设计将包括 使用智能手机管理35个对广泛认知功能的简短评估 在为期一周的测量范围内，以九个月的间隔进行了三次，并重复3次。这 密集的测量方法允许评估“实时”认知功能 可以提供更可靠的功能索引，该索引对更改更敏感。这个目的 提案是： A1。证明MHD可以适应布朗克斯区的潜水员中年队列。评价 干预前后血清生物标志物指示MHD饮食模式，特别是总计 叶酸和维生素，生育酚，类胡萝卜素，维生素B12和脂肪酸剖面；并自我报告 摄入诸如水果和绿叶蔬菜之类的食物基团，以比较研究臂。 A2。测试在多种族城市环境中的MHD干预是否可以使认知受益 在中年人口中发挥作用。评估认知功能（空间工作记忆，短 术语记忆，自我报告的精神清晰度，处理速度），使用实时卧床 每9个月的7天内评估，以评估时间课程 积极影响是可以检测到的。 A3。确定与稳定或改进措施相关的MHD饮食的组成部分 认知。我们将评估指示MHD饮食模式的生物标志物（请参阅A1），并与 认知功能度量。