Implications of the 2004-2005 Influenza Vaccine Shortage

2004-2005 年流感疫苗短缺的影响

• 批准号: 8608478
• 负责人: SRIKANTH KADIYALA
• 金额: $ 24.52万
• 依托单位: RAND CORPORATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8608478
• 关键词: Absenteeism; Absenteeism at work; Accounting; Address; Affect; Area; Behavioral; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Country; Data; Data Set; Data Sources; Decision Making; Dose; Drops; Failure; Health; Herd Immunity; Individual; Infection; Influenza; Influenza vaccination; Intervention; Licensure; Manufacturer Name; Marketing; Measures; Medical; Methodology; Morbidity - disease rate; Natural experiment; Outcome; Plants; Policies; Policy Maker; Population; Preventive; Production; Productivity; Public Policy; Randomized Controlled Trials; Risk Factors; Schools; Seasons; Shock; Students; Surveys; United States; Vaccinated; Vaccination; Vaccines; Variant; Work; chiron vaccine; cost; design; evidence base; experience; flu; health care service utilization; health economics; influenza virus vaccine; innovation; instrument; interest; mortality; population health; prevent; public health relevance; seasonal influenza; social

DESCRIPTION (provided by applicant): Influenza vaccination protects individuals against infection, reduces absenteeism at work and missed days of school. The 2004-2005 flu season saw a substantial reduction in influenza vaccination rates due to a shortage in the supply of the influenza vaccine. Due to failure of a Chiron production plant, compared to previous years, there was approximately a 31 million-dose shortage of the influenza vaccine and vaccination rates in the country dropped by nearly 25%. In this proposal we aim to take advantage of this natural experiment to estimate the effect of this reduction in vaccination supply on a variety of outcomes including health care utilization, mortality, work productivity and school absenteeism. Specifically, we take advantage of the fact that states that ordered vaccinations specifically from Chiron were more likely to experience a vaccine shortage than states that did not order their vaccinations from Chiron. Calculations of state level vaccination rates from the Behavioral Risk Factor Social Survey data indicate substantial cross-state variation in reductions in vaccination rates due to the shortage, with some states experiencing nearly a 40% reduction in vaccination rates while other states experienced little to no reduction. In the analyses, using unique data from the CDC on state vaccination orders specifically to Chiron, we first instrument for the reduction in state vaccination rates in the 2004-2005 flu season. We then estimate the impact of this reduction on state level measures of health care utilization, influenza mortality, work productivity and school attendance. Compared to previous work in this area, our study promises to provide comprehensive estimates of the effects of the vaccination on these outcomes since we are able to capture these outcomes for both vaccinated and unvaccinated individuals in these states. A more comprehensive accounting of the benefits of vaccination has the potential to affect policy maker decision making with respect to the utilization of the influenza vaccination to increase population health.

描述（由申请人提供）：流感疫苗接种可以保护个人免受感染，减少缺勤和缺课的情况。 2004-2005年流感季节，由于流感疫苗供应短缺，流感疫苗接种率大幅下降。由于Chiron生产工厂的故障，与往年相比，该国流感疫苗短缺约3100万剂，疫苗接种率下降了近25%。 在本提案中，我们的目标是利用这一自然实验来估计疫苗供应减少对各种结果的影响，包括医疗保健利用率、死亡率、工作生产力和缺勤率。具体来说，我们利用了这样一个事实：各州专门从 与没有从 Chiron 订购疫苗的州相比，Chiron 更有可能出现疫苗短缺的情况。根据行为风险因素社会调查数据计算的州级疫苗接种率表明，由于疫苗短缺，疫苗接种率下降的跨州差异很大，一些州的疫苗接种率下降了近 40%，而其他州则几乎没有下降。 。 在分析中，我们利用 CDC 专门针对 Chiron 的各州疫苗接种订单的独特数据，首先对 2004-2005 流感季节各州疫苗接种率的下降进行了分析。然后，我们估计这种减少对州级医疗保健利用率、流感死亡率、工作生产力和入学率指标的影响。与该领域之前的工作相比，我们的研究有望提供疫苗接种对这些结果的影响的全面估计，因为我们能够捕获这些州接种疫苗和未接种疫苗的个体的这些结果。对疫苗接种益处进行更全面的核算可能会影响政策制定者有关流感疫苗接种的决策 提高人口健康水平。

项目成果

The Effect of the 2009 Influenza Pandemic on Absence from Work.

2009 年流感大流行对缺勤的影响。

• 发表时间: 2017-12
• 影响因子: 2.1
• 作者: Duarte, Fabian;Kadiyala, Srikanth;Masters, Samuel H;Powell, David
• 通讯作者: Powell, David