Evaluating Vocal Fold Tissue Structure and Vibratory Stress

评估声带组织结构和振动应力

• 批准号: 9051471
• 负责人: Erin E Devine
• 金额: $ 3.67万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-31 至 2017-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9051471
• 关键词: Absenteeism at work; Accounting; Acoustics; Adult; Affect; American; Anisotropy; Behavior; Benign; Biomechanics; Caring; Chronic Disease; Chronic Obstructive Airway Disease; Clinical; Clinical Management; Collagen; Computer Simulation; Computers; Congestive Heart Failure; Cyst; Data; Dehydration; Development; Disease; Dysphonia; Elements; Evaluation; Evaluation Studies; Extracellular Matrix; Fatigue; Fiber; Generations; Goals; Gray unit of radiation dose; Health Care Costs; Hydration status; Image; Impairment; Inflammation; Intercellular Fluid; Intervention; Knowledge; Lamina Propria; Larynx; Laser Scanning Microscopy; Lead; Lesion; Liquid substance; Measures; Mechanics; Medical; Methods; Modeling; Movement; Nodule; Normal tissue morphology; Oryctolagus cuniculus; Patients; Phase; Phonation; Physiological; Physiology; Play; Polyps; Property; Quality of life; Recommendation; Relaxation; Research; Resistance; Role; Rupture; Solid; Spatial Distribution; Speed; Stress; Structure; Swelling; Therapeutic; Therapeutic Intervention; Tissues; Trauma; Ultrasonography; Voice; Voice Disorders; Wages; Weight-Bearing state; Work; cost; disability; elastography; experience; improved; interest; kinematics; novel; pressure; public health relevance; second harmonic; socioeconomics; soft tissue; trend; vibration; vocal cord

 DESCRIPTION (provided by applicant): Benign glottic lesions are generally believed to result from mechanical trauma to the vocal folds, and affect million of working Americans. However, the extent of trauma and loading conditions that lead to structural damage, inflammation, and ultimately lesions such as nodules, polyps or cysts, is not well defined. In order to better understand the loading conditions and vocal behaviors that can lead to damage, greater understanding of material properties, stress distributions, and the resulting fiber damage is necessary. Vocal fold tissues experience a type of loading that is unique among soft tissues of the body. They undergo vibration and are loaded in the axial and transverse directions in tension, compression and shear, while most soft tissues are loaded either in tension or compression in a single direction. Because of this difference in load bearing, the structure (extracellular matrix fiber arrangement) and material property trends of the vocal folds differs from other softer tissues, making study of the vocal fold tissue properties critical for understanding the mechanism of structural damage leading to lesions. The overall goal of this proposal is to evaluate the material properties of the vocal folds, the stress experienced during phonation under varying hydration, elongation and subglottal pressure conditions, and the resulting structural damage to the tissue. The results will potentially describe the forces of vibration that result in tissue damage- either fatigue damage or fiber rupture. Methods of material property estimation and structural damage evaluation are novel and will contribute to knowledge about vocal fold tissue properties. Knowledge gained from this research is essential for a more complete understanding of clinical management of voice disorders. The approach to this research will involve three specific aims. The first aim will focus on characterizing vocal fod material properties. It will employ acousto-elastography, which is a novel measure of the tissue acoustic properties that is linearly related to strain and nonlinearly related to tissue stress. Th results of these methods will be useful for establishing the effects of dehydration on tissue stiffness and informing computer model parameters. The second aim will focus on finite element modeling of vocal fold vibration and the resulting interstitial fluid dynamics and stress distributions. Elongation, subglottal pressure, hydration and stiffness will be varied and resultin stresses evaluated. The third aim will focus on excised studies and evaluation of tissue damage under varying subglottal pressure, hydration and elongation phonation challenges. The potential long term implications of this work are (1) better characterizing the vocal behaviors that might lead to lesions to inform therapeutic recommendations and (2) a better understanding of the mechanism of lesion formation to inform interventions.

 描述（由申请人提供）：良性声门病变通常被认为是由声带机械损伤引起的，然而，导致结构损伤、炎症和最终损伤的损伤程度和负荷条件导致了数以百万计的美国人。为了更好地了解可能导致损伤的负载条件和声带行为，需要更好地了解材料特性、应力分布以及由此产生的声带组织损伤。一个它们承受振动并在轴向和横向上承受拉伸、压缩和剪切载荷，而大多数软组织在单一方向上承受拉伸或压缩载荷。声带在承载、结构（细胞外基质纤维排列）和材料特性趋势方面的差异与其他软组织不同，使得声带组织特性的研究对于理解导致病变的结构损伤机制至关重要。该提案旨在评估材料特性声带的结构、在不同的水合、伸长和声门下压力条件下发声时所经历的应力，以及由此产生的组织结构损伤。结果将潜在地描述导致组织损伤的振动力——疲劳损伤或纤维断裂。材料特性估计和结构损伤评估的方法是新颖的，将有助于了解声带组织特性。从这项研究中获得的知识对于更全面地了解声音障碍的临床治疗至关重要。这项研究的方法将涉及三种方法。具体目标第一。目标将集中于表征声音食品材料的特性，这是一种与应变线性相关、与组织应力非线性相关的组织声学特性的新颖测量方法。这些方法的结果将有助于建立组织声学特性。第二个目标将集中于声带振动的有限元建模以及由此产生的间质流体动力学和应力分布。第三个目标将侧重于不同声门下压力、水合和伸长发声挑战下的组织损伤的切除研究和评估。这项工作的潜在长期影响是（1）更好地表征声音。可能导致病变的行为，为治疗建议提供信息；(2) 更好地了解病变形成机制，为干预措施提供信息。