Clinical Core

临床核心

基本信息

批准号：
9922628
负责人：
LON S SCHNEIDER
金额：
$ 79.42万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9922628
关键词：
Address Alzheimer disease prevention Alzheimer&apos s Disease Arts Autopsy Basic Science Biological Markers Blood Blood Vessels California Caregiver support Caregivers Caring Cerebrovascular system Clinic Clinical Clinical Data Clinical Research Clinical Trials Cohort Studies Collaborations Collection Communities Comprehensive Health Care Data Data Set Databases Dementia Diagnosis Disease Elderly Engineering Enrollment Evaluation Funding Generations Goals Huntington Disease Image Impaired cognition Individual Infrastructure Institutes Leadership Learning Letters Longitudinal cohort Magnetic Resonance Imaging Measures Medical Medical Research Metabolic Molecular Monitor Multi-site clinical study Neuropsychology Participant Pathogenesis Pathologic Patients Phase Physicians Positron-Emission Tomography Postdoctoral Fellow Prevention Puncture procedure Research Research Institute Research Personnel Research Project Grants Risk Risk Factors Role Schedule Schools Specimen Spinal Puncture Targeted Research Technology Translational Research Underrepresented Groups United States National Institutes of Health Vascular Cognitive Impairment Vascular Diseases Venipunctures Work brain research caregiving cerebrovascular cohort college data management data sharing drug development early phase clinical trial ethnic diversity functional status health disparity imaging biomarker indexing medical schools neuroimaging neuropathology neurovascular unit new therapeutic target novel recruit research study statistics tool trial design vascular contributions vascular risk factor volunteer willingness

项目摘要

Abstract The Clinical Core serves the USC ADRC’s themes, cerebrovascular and metabolic contributions to cognitive impairment; vascular and metabolic risk factors in cognitive decline; Alzheimer pathogenesis; and the prevention and treatment of Alzheimer-related disorders. The Core’s three overarching objectives are to: 1) develop and maintain a vascular risk factors cohort; 2) catalyze local, clinical and translational research, including early phase clinical trials; 3) provide expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The Core addresses many important goals of the 2011 National Alzheimer Project Act (NAPA): translational tools, infrastructure, trial design and conduct, novel drug targets, research on caregiver support, recruitment and citizen engagement, biomarkers, health disparities, data sharing, and enabling technologies. The Core enrolls and retains the primary ADRC cohorts, i.e., the Vascular Cohort Study, Brain Research (autopsy) Study, and participants co-enrolled in Affiliated-Studies. The core performs standard evaluations and diagnoses, oversees neuroimaging and blood and CSF biomarker collection. For this renewal, the core plans to increase the vascular cohort, enrollment for autopsy, and Latinx participation; and continue to provide infrastructure for over 25 ADRC-affiliated, independently-funded research studies including USC Investigator- initiated NIH-funded clinical studies. The core is an integrated, collaborative team, including physicians (Lon Schneider, Helena Chui, John Ringman, Elizabeth Joe, Sonia Pawluczyk), neuropsychologists (Lina D’Orazio, Carol McCleary), and other investigators (Hussein Yassine, Judy Pa, Michael Harrington). Its specific aims are to: 1) collaborate with the other ADRC cores to support the ADRC’s central theme by recruiting and maintaining the vascular risk cohort; 2) recruit and maintain an ethnically diverse cohort focusing on Latinx individuals and emphasizing vascular and metabolic risk, ADRC participation, and affiliated funded studies; 3) recruit and maintain a the Brain Research Study cohort and work with other cores to share specimens; 4) perform annual NACC Uniform Data Set (UDS) evaluations, submit data to NACC, promote an integrated national database, facilitate collaborative research and data sharing; 5) advance USC’s participation and leadership in national collaborative studies by recruiting, retaining participants in ADRC-affiliated national and multicenter projects; 6) enhance recruitment and promote dementia prevention efforts and translational research opportunities in collaboration with the ORE core that particularly includes participants from Latinx and underrepresented groups, and from the USC California-funded Alzheimer’s Disease Centers (CADC), and Roybal Comprehensive Healthcare Clinic; and 7) support neuroimaging and biofluid biomarker studies.

抽象的临床核心服务于USC ADRC的主题，脑血管和代谢对认知的贡献损害；认知下降的血管和代谢危险因素；阿尔茨海默氏症发病机理；和预防和阿尔茨海默氏症相关疾病的治疗。核心的三个总体目标是：1）开发和保持血管危险因素队列； 2）催化本地，临床和翻译研究，包括早期临床试验； 3）为民族合作提供血管疾病，生物标志物和成像的专业知识倡议。核心核心解决了2011年国家阿尔茨海默剂项目法（NAPA）的许多重要目标：翻译工具，基础设施，试验设计和行为，新型药物目标，护理人员支持研究，招聘和公民参与，生物标志物，健康分布，数据共享和启用技术。核心注册并保留主要的ADRC队列，即血管队列研究，大脑研究（尸检）研究，参与者在附属研究中共同注册。核心执行标准评估，诊断，监督神经影像，血液以及CSF生物标志物收集。对于此续约，核心计划增加血管队列，尸检入学率和拉丁裔参与；并继续提供超过25个ADRC附属，独立资助的研究的基础设施，包括USC研究者 - 启动了NIH资助的临床研究。核心是一个综合的协作团队，包括医生（LON） Schneider，Helena Chui，John Ringman，Elizabeth Joe，Sonia Pawluczyk），神经心理学家（Lina D'Orazio，卡罗尔·麦克拉里（Carol McClary）和其他调查人员（侯赛因·亚西（Hussein Yassine），朱迪·帕（Judy Pa），迈克尔·哈灵顿（Michael Harrington））。它的具体目的是：1）与其他ADRC核心合作，以支持ADRC的中心主题招募和维持血管风险队列； 2）招募和保持种族多样化的队列聚焦在拉丁裔个人上，并强调血管和代谢风险，ADRC参与和会员资助研究； 3）招募和维护脑研究队列并与其他核心合作共享标本； 4）执行年度NACC统一数据集（UDS）评估，将数据提交给NACC，促进集成国家数据库，促进协作研究和数据共享； 5）提高USC的参与和通过招聘，保留ADRC附属国家和参与者的国家合作研究领导多中心项目； 6）增强招募并促进预防痴呆症和转化研究与矿石核心合作的机会，特别包括拉丁裔和代表不足的群体，以及来自加州加州资助的阿尔茨海默氏病中心（CADC）和皇家综合医疗诊所； 7）支持神经影像学和生物流体生物标志物研究。