Clinical Core

临床核心

基本信息

批准号：
9922628
负责人：
LON S SCHNEIDER
金额：
$ 79.42万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9922628
关键词：
Address Alzheimer disease prevention Alzheimer&apos s Disease Arts Autopsy Basic Science Biological Markers Blood Blood Vessels California Caregiver support Caregivers Caring Cerebrovascular system Clinic Clinical Clinical Data Clinical Research Clinical Trials Cohort Studies Collaborations Collection Communities Comprehensive Health Care Data Data Set Databases Dementia Diagnosis Disease Elderly Engineering Enrollment Evaluation Funding Generations Goals Huntington Disease Image Impaired cognition Individual Infrastructure Institutes Leadership Learning Letters Longitudinal cohort Magnetic Resonance Imaging Measures Medical Medical Research Metabolic Molecular Monitor Multi-site clinical study Neuropsychology Participant Pathogenesis Pathologic Patients Phase Physicians Positron-Emission Tomography Postdoctoral Fellow Prevention Puncture procedure Research Research Institute Research Personnel Research Project Grants Risk Risk Factors Role Schedule Schools Specimen Spinal Puncture Targeted Research Technology Translational Research Underrepresented Groups United States National Institutes of Health Vascular Cognitive Impairment Vascular Diseases Venipunctures Work brain research caregiving cerebrovascular cohort college data management data sharing drug development early phase clinical trial ethnic diversity functional status health disparity imaging biomarker indexing medical schools neuroimaging neuropathology neurovascular unit new therapeutic target novel recruit research study statistics tool trial design vascular contributions vascular risk factor volunteer willingness

项目摘要

Abstract The Clinical Core serves the USC ADRC’s themes, cerebrovascular and metabolic contributions to cognitive impairment; vascular and metabolic risk factors in cognitive decline; Alzheimer pathogenesis; and the prevention and treatment of Alzheimer-related disorders. The Core’s three overarching objectives are to: 1) develop and maintain a vascular risk factors cohort; 2) catalyze local, clinical and translational research, including early phase clinical trials; 3) provide expertise in vascular disease, biomarkers, and imaging to national collaborative initiatives. The Core addresses many important goals of the 2011 National Alzheimer Project Act (NAPA): translational tools, infrastructure, trial design and conduct, novel drug targets, research on caregiver support, recruitment and citizen engagement, biomarkers, health disparities, data sharing, and enabling technologies. The Core enrolls and retains the primary ADRC cohorts, i.e., the Vascular Cohort Study, Brain Research (autopsy) Study, and participants co-enrolled in Affiliated-Studies. The core performs standard evaluations and diagnoses, oversees neuroimaging and blood and CSF biomarker collection. For this renewal, the core plans to increase the vascular cohort, enrollment for autopsy, and Latinx participation; and continue to provide infrastructure for over 25 ADRC-affiliated, independently-funded research studies including USC Investigator- initiated NIH-funded clinical studies. The core is an integrated, collaborative team, including physicians (Lon Schneider, Helena Chui, John Ringman, Elizabeth Joe, Sonia Pawluczyk), neuropsychologists (Lina D’Orazio, Carol McCleary), and other investigators (Hussein Yassine, Judy Pa, Michael Harrington). Its specific aims are to: 1) collaborate with the other ADRC cores to support the ADRC’s central theme by recruiting and maintaining the vascular risk cohort; 2) recruit and maintain an ethnically diverse cohort focusing on Latinx individuals and emphasizing vascular and metabolic risk, ADRC participation, and affiliated funded studies; 3) recruit and maintain a the Brain Research Study cohort and work with other cores to share specimens; 4) perform annual NACC Uniform Data Set (UDS) evaluations, submit data to NACC, promote an integrated national database, facilitate collaborative research and data sharing; 5) advance USC’s participation and leadership in national collaborative studies by recruiting, retaining participants in ADRC-affiliated national and multicenter projects; 6) enhance recruitment and promote dementia prevention efforts and translational research opportunities in collaboration with the ORE core that particularly includes participants from Latinx and underrepresented groups, and from the USC California-funded Alzheimer’s Disease Centers (CADC), and Roybal Comprehensive Healthcare Clinic; and 7) support neuroimaging and biofluid biomarker studies.

抽象的临床核心服务于 USC ADRC 的主题：脑血管和代谢对认知的贡献认知能力下降的血管和代谢危险因素；核心的三个总体目标是：1）开发和治疗阿尔茨海默病相关疾病。维持血管危险因素队列；2) 促进本地、临床和转化研究，包括早期阶段临床试验；3) 向国家协作提供血管疾病、生物标志物和影像方面的专业知识该核心解决了 2011 年国家阿尔茨海默病项目法案 (NAPA) 的许多重要目标：转化工具、基础设施、试验设计和实施、新药物靶点、护理人员支持研究、招聘和公民参与、生物标志物、健康差异、数据共享和支持技术。核心招募并保留主要 ADRC 队列，即血管队列研究、脑研究（尸检）研究，参与者共同参加附属研究，核心进行标准评估和评估。诊断、监督神经影像以及血液和脑脊液生物标志物收集对于此次更新，核心计划：增加血管队列、尸检登记和拉丁裔参与，并继续提供；超过 25 个 ADRC 附属、独立资助的研究的基础设施，包括 USC Investigator- 发起由 NIH 资助的临床研究，其核心是一个综合的协作团队，包括医生（Lon）。 Schneider、Helena Chui、John Ringman、Elizabeth Joe、Sonia Pawluczyk）、神经心理学家（Lina D’Orazio、 Carol McCleary）和其他调查员（Hussein Yassine、Judy Pa、Michael Harrington）。其具体目标是： 1）与其他 ADRC 核心合作，通过以下方式支持 ADRC 的中心主题：招募和维持血管风险队列；2) 招募和维持种族多元化的队列；针对拉丁裔个体并强调血管和代谢风险、ADRC 参与以及附属资助研究；3）招募和维持大脑研究队列并与其他核心合作共享样本； 4）执行年度NACC统一数据集（UDS）评估，向NACC提交数据，促进综合国家数据库，促进合作研究和数据共享；5）促进南加州大学的参与和通过招募、留住 ADRC 附属国家和地区的参与者，在国家合作研究中发挥领导作用多中心项目；6) 加强招募并促进痴呆症预防工作和转化研究与 ORE 核心合作的机会，特别是来自拉丁美洲和加勒比地区的参与者代表性不足的群体，以及来自南加州大学加州资助的阿尔茨海默病中心 (CADC)，以及 Roybal 综合医疗保健诊所；7) 支持神经影像学和生物流体生物标志物研究。