Yale Clinical and Epidemiology Research in Neurology (CERN) Training Program

耶鲁大学神经病学临床和流行病学研究 (CERN) 培训计划

• 批准号: 9919004
• 负责人: JUDITH H LICHTMAN
• 金额: $ 31.7万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9919004
• 关键词: Clinical Research; Neurology; Training Programs; epidemiology study

This is a proposal to support the Yale Clinical and Epidemiology Research in Neurology (CERN) Training Program. The thematic concept and single focus of the proposed program is to train clinical neurologists in clinical and epidemiological research methods. Yale has an exceptionally strong existing research base in clinical neuroscience investigation. The Department of Neurology is ranked the 9th highest clinical neurology department in NIH funding. The critical mass of mentors with specific expertise in epidemiology and clinical research relevant to the neurosciences has led to a natural expansion of the training opportunities at Yale, fostering the development of the proposed program. The engagement of these mentors will provide an outstanding foundation for this novel research training. Our proposed program encompasses four key neurologic disease areas: cerebrovascular disease, neurodegeneration and aging, neuroinflammation, and epilepsy. The program is supported by 20 carefully-selected faculty across the Schools of Medicine and Public Health (YSPH). Our objective is to provide a closely mentored rigorous research training program for postdoctoral physician scientists to gain education and experience with the tools necessary for investigative academic careers focused on human subjects research. Two new CERN Training Program fellows per year will be selected for a two-year training program from clinically trained candidates with MD degrees and prior neurological specialty training (i.e., neurology residency). Central to the training experience will be pursuit of a project involving clinical or epidemiological research in neurology. In addition to pursuing mentored research projects, trainees will complete core coursework in these areas offered through the YSPH, and will participate in a series of regularly scheduled didactic series, seminars and workshops, and a course on the responsible conduct of research, which are available through the Yale Center for Neuroepidemiology and Clinical Neurological Research (CNE2) and the Yale Center for Clinical Investigation (YCCI). Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and YCCI- and YSPH-supported grant-writing workshops, with the goal of having successfully applied for independent career development awards by the conclusion of the fellowship. With abundant resources in the form of study participants, existing cohorts and datasets, outstanding collaborators, and educational opportunities, Yale provides an exemplary environment for clinical and epidemiologic neurologic research. This will be leveraged through this program to train a cadre of leading patient-oriented investigators, with a shared goal of prevention of or reduction of morbidity and mortality associated with neurological disease.

这是一项支持耶鲁大学神经病学临床和流行病学研究（CERN）的建议。 培训计划。拟议程序的主题概念和单一重点是培训临床 临床和流行病学研究方法的神经科医生。耶鲁大学有一个异常强大的现有 临床神经科学研究的研究基础。神经病学系排名第9 NIH资助中最高的临床神经病学系。具有特定专业知识的导师的关键质量 在与神经科学有关的流行病学和临床研究中 耶鲁大学的培训机会，促进了拟议计划的发展。参与 这些导师将为这项新型研究培训提供杰出的基础。我们提出的 程序包括四个关键神经疾病领域：脑血管疾病，神经退行性 以及衰老，神经炎症和癫痫。该计划得到20位精心挑选的教师的支持 在医学和公共卫生学校（YSPH）中。我们的目标是提供密切的指导 博士后医师科学家的严格研究培训计划获得教育和经验 借助调查学术职业所需的工具，专注于人类学科研究。二 每年新的CERN培训计划研究员将被选为一项为期两年的培训计划 具有MD学位的临床训练候选人和先前的神经学专业培训（即神经病学 居住）。培训经验的核心将是追求涉及临床或 神经病学流行病学研究。除了追求指导的研究项目外，学员还将 通过YSPH提供的这些领域的完整核心课程，并将参加一系列 定期安排的教学系列，研讨会和讲习班，以及负责举止的课程 研究，可通过耶鲁神经ePidemiology and Clinical Neurology中心获得 研究（CNE2）和耶鲁大学临床研究中心（YCCI）。通过精心选择的 教学和教育计划，并通过正式的指导对学员进步进行密切监控 过程，学员将获得设计和执行严格的调查项目的技能，分析他们的 数据，并发布其结果。学员将受到导师的指导，YCCI-和YSPH支持 赠款写作研讨会，目的是成功申请独立职业发展 奖励奖学金结束。以研究参与者的形式拥有丰富的资源， 耶鲁大学现有的队列和数据集，杰出的合作者以及教育机会，提供了一个 临床和流行病学神经系统研究的示例性环境。这将通过 该计划培训一群领先的以患者为导向的研究人员，共同预防 或降低与神经疾病相关的发病率和死亡率。