Integrative Training in the Neurocircuitry of Affective Disorders

情感障碍神经回路的综合训练

• 批准号: 9917853
• 负责人: YVETTE I SHELINE
• 金额: $ 23.56万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9917853
• 关键词: Mood Disorders; Training; neural circuit

 DESCRIPTION (provided by applicant):Title: Integrated Training in Neurocircuitry of Affective Disorders The proposed revised Institutional National Research Service Award Training Program will provide basic and clinical neuroscientists with the skills and mentor-guided experiences to propel them into an interdisciplinary research career designed to further the understanding of brain circuitry and affect. We request funds for two positions in Year 1 and four positions each subsequent year. The area of brain circuitry as applied to understanding psychopathology is a rapidly growing domain with great potential to inform the understanding of the causal pathways and mechanisms of affective mental illness. The Center for Neuromodulation in Depression and Stress (CNDS), in collaboration with multiple University of Pennsylvania (PENN) departments, centers and institutes is well poised to launch this novel post-doctoral fellowship based on established innovations in imaging, as well as the range of related expertise offered by the proposed multidisciplinary mentor group. The proposed training recognizes that the tools necessary to understand brain circuitry pathology require training across psychopathology, human neuroimaging methodology, statistics, engineering, neuroscience, genetics and basic translational models with associated imaging, such as optogenetics. The program will be guided by Dr. Yvette Sheline, (neuroimaging of depression and stress). Dr. John Detre (clinical neuroscience and methods development in functional neuroimaging) will be Associate Director. They are joined by numerous investigators at PENN with a rich track record of experience in imaging of affective disorders, including a cadre of investigators at the forefront of new methods development; many of these labs will be co-located, along with trainees, in a new facility. Research taking a brain circuit approach to psychopathology using a neuroscience model is a novel approach for training. The program mentors provide a unique multidisciplinary training environment in which to pursue this exciting new approach, given the established collaborations between neuroimaging researchers in the clinical and basic departments of the Perelman School of Medicine and their interface with the Biomedical Graduate Studies program. The University's role at the forefront of neuroimaging and translational neuroscience offers an opportunity to help train the next generation of young scientists who can pursue fundamental questions about abnormalities in brain circuitry in affective illness from the perspective of core psychological, neural and translational mechanisms that can inform and span traditional boundaries of psychopathology and lead to more effective treatments and identification of new targets for prevention.

 描述（由申请人提供）：标题：情感障碍神经回路综合培训拟议修订的机构国家研究服务奖培训计划将为基础和临床神经科学家提供技能和导师指导的经验，推动他们进入跨学科研究职业，旨在进一步加深对大脑回路和情感的理解。我们为第一年的两个职位申请资金，并在随后的每年申请四个职位。用于理解精神病理学的大脑回路领域是一个快速发展的领域，具有巨大的潜力。抑郁和压力神经调节中心 (CNDS) 与宾夕法尼亚大学 (PENN) 多个院系、中心和研究所合作，准备推出这一新颖的后治疗方法。博士奖学金基于成像领域的既定创新以及拟议的多学科导师小组提供的相关专业知识范围。拟议的培训认识到理解脑回路病理学所需的工具需要跨精神病理学、人类神经成像方法、统计学、工程学的培训。 ,神经科学、遗传学和相关成像的基本转化模型，例如光遗传学，该项目将由 Yvette Sheline 博士（抑郁和压力的神经成像）John Detre 博士（功能神经成像的临床神经科学和方法开发）指导。 PENN 的众多研究人员在情感障碍成像方面拥有丰富的经验，其中包括处于新方法开发前沿的骨干研究人员。与受训者一起在一个新设施中进行研究，利用神经科学模型对精神病理学进行脑回路研究，这是一种新颖的培训方法，项目导师提供了一个独特的多学科培训环境，可以在其中追求这种令人兴奋的新方法。鉴于佩雷尔曼医学院临床和基础部门的神经影像研究人员之间已建立的合作以及他们与生物医学研究生项目的联系，该大学在神经影像和转化神经科学的前沿发挥着作用，为帮助培养下一代提供了机会。年轻科学家可以从核心心理、神经和转化机制的角度探讨情感疾病中大脑回路异常的基本问题，这些机制可以告知和跨越精神病理学的传统界限，并导致更有效的治疗和确定新的预防目标。