Malaria vectorial system and vector control in Southeast Asia

东南亚的疟疾媒介系统和媒介控制

基本信息

批准号：
9915851
负责人：
Jetsumon Prachumsri
金额：
$ 80.36万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9915851
关键词：
Address Affect Animals Anopheles Genus Area Behavior Behavioral Behavioral Mechanisms Biological Assay Bionomics Breeding Candidate Disease Gene China Communities Complex Culicidae Deforestation Development Drug Metabolic Detoxication Ecology Environmental Impact Epidemiology Exhibits Feeding behaviors Genes Genetic Genetic Drift Genetic Structures Genetic Variation Genomics Geography Heterogeneity High-Throughput Nucleotide Sequencing Human Insecticide Resistance Insecticides International Intervention Knowledge Malaria Maps Measures Metabolic Mining Monitor Mosquito Control Mutation Myanmar Parasites Pattern Phenotype Population Population Dynamics Population Genetics Proteins Research Residual state Resistance Rest Sampling Site Southeastern Asia Spatial Distribution Structure Surveys System Techniques Technology Testing Thailand Update Vector Ecology agricultural activity anthropogenesis base behavioral phenotyping deep sequencing environmental change environmental intervention experience feeding genetic information genome wide association study genomic tools improved knowledge base malaria transmission next generation sequencing overexpression population genetic structure preference programs pyrethroid tool trait transcriptome sequencing transmission process vector vector competence vector control vector mosquito

项目摘要

PROJECT 2 SUMMARY Malaria epidemiology in the Greater Mekong Subregion is characterized by high spatial and temporal heterogeneity with the presence of diverse vector species, which have different spatial distribution, seasonal dynamics, ecological niche requirement, host feeding preference and vector competence. Vector control is an integrated component of malaria control. The changes in mosquito biting behavior and emergence of resistance to pyrethroid insecticides make the conventional pyrethroid insecticide-treated nets and pyrethroid- based indoor residual spray less effective in reducing malaria transmission. Environmental changes, especially due to deforestation, also have led to dramatic changes in the bionomics and vectorial status of different Anopheles species. Therefore, updated knowledge on such changes and development of new resistance monitoring tools are critically needed. In order to address these pressing challenges in vector control, we selected international border regions in China, Thailand and Myanmar to 1) determine how environmental changes affect the mosquito community structures, 2) study the mosquito phenotypic plasticity and characterize landscape genetics of a major Anopheles vector species, 3) identify whether changes of mosquito biting behaviors are genetically determined using genomics technology, and 4) determine the extent, distribution and mechanisms of insecticide resistance in a major malaria vector. The overarching objectives of this project are to understand the vectorial system in diverse ecological and epidemiological settings and to develop the needed knowledge base for effective vector control in the GMS.

项目2摘要大湄公河区域中的疟疾流行病学的特征是高空间和时间。具有不同空间分布，季节性的不同矢量物种的异质性动力学，生态利基需求，宿主喂养偏好和向量能力。向量控制是疟疾控制的综合成分。蚊子咬人行为和出现的变化对拟除虫菊酯杀虫剂的抗性使常规的拟除虫菊酯杀虫剂治疗的网和拟除虫菊酯 - 基于室内残留喷雾在减少疟疾传播方面效率较低。尤其是环境变化由于森林砍伐，也导致了不同肛门物种。因此，有关这种变化和开发新抵抗的知识的最新知识监视工具至关重要。为了解决向量控制中的这些紧迫挑战，我们在中国，泰国和缅甸选定的国际边境地区至1）确定环境如何变化影响蚊子社区结构，2）研究蚊子表型可塑性和表征主要的肛门载体物种的景观遗传学，3）确定蚊子的变化是否变化咬人行为是使用基因组技术在遗传上确定的，4）确定程度，主要疟疾载体中杀虫剂抗性的分布和机制。总体目标该项目旨在了解各种生态和流行病学环境中的媒介系统以及为GMS中的有效向量控制建立所需的知识库。