Visual-Motor Development in Infants at High Risk for Autism

自闭症高危婴儿的视觉运动发育

• 批准号: 9915960
• 负责人: Mary Beth Nebel
• 金额: $ 14.89万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915960
• 关键词: Advisory Committees; Affect; Age-Months; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Biomedical Engineering; Body part; Brain; Brain imaging; Child; Classification; Code; Collection; Data; Development; Diagnosis; Diagnostics Research; Early Intervention; Exhibits; Goals; Grant; Image; Impairment; Infant; Infant Development; Institutes; International; Intervention; Knowledge; Laboratories; Language; Lead; Learning; Life; Link; Magnetic Resonance Imaging; Manuals; Measures; Mediating; Mentored Research Scientist Development Award; Mentors; Motor; Movement; Nature; Neurodevelopmental Disorder; Outcome; Outcome Study; Parents; Pathway interactions; Pattern; Play; Research; Research Project Grants; Resources; Rest; Risk; Sampling; Scheme; School-Age Population; Science; Scientist; Sensory; Severities; Sleep; Social skills development; Study Subject; Symptoms; System; Testing; Time; Toddler; Training; Visual; Visual Motor Coordinations; Visual system structure; Work; autism spectrum disorder; autistic children; base; behavior measurement; behavioral outcome; behavioral study; career; clinical care; discounting; experience; eye hand coordination; functional outcomes; high risk; high risk infant; imaging approach; imaging study; improved; individual response; motor behavior; motor deficit; motor disorder; motor impairment; motor learning; neuroimaging; novel; programs; public health relevance; relating to nervous system; segregation; skill acquisition; skills; social; social deficits; statistics; vision development; visual feedback; visual motor; visual-motor integration

 DESCRIPTION (provided by applicant): The candidate is a biomedical engineer, committed to developing neuroimaging and behavioral strategies to elucidate developmental mechanisms leading to motor and social deficits in children with Autism Spectrum Disorder (ASD). School-age children with ASD exhibit particular difficulty with tasks that rely on hand-eye coordination and show what appears to be an ASD-specific discounting of visual feedback when learning novel movements. In addition, non-specific perturbations to motor development are observable within the first year of life in infants who later develop ASD and may be among the earliest signs of ASD. Early imitation behavior, which depends critically on visual-motor integration, has been linked with subsequent language and play development in children with ASD and is a common target for intervention. Thus, closer examination of the emergence of motor, and specifically visual-motor, deficits is of critical importance to ASD. We propose to investigate trajectories of visual-motor integration in infants at risk for ASD using both behavioral and brain imaging approaches. To carry out this research, we have begun to develop a novel behavioral measure of visual-motor coordination in infants during a ball-catching task. We will also use resting state functional connectivity MRI (fcMRI) data collected during natural sleep to extract neural measures of visual-motor integration from the same infants. Aims 1 and 2 are focused on extracting these behavioral and neural measures of visual-motor function from AOSI videos and fcMRI data compiled by the Infant Brain Imaging Study (IBIS). We will investigate whether baseline abnormalities and developmental trajectories for these behavioral and neural measures of visual-motor integration differentially predict functional outcomes in affected high-risk infants versus unaffected high-risk infants and controls. Exploratory Aim 3 will then test whether behavioral and neural measures of visual-motor integration can predict individual responses to a parent- mediated intervention using visual-manual activities to target socially engaged imitation. If successful, identifying the neurodevelopmental basis of visual-motor abnormalities in ASD could help stratify ASD into more tractable conditions, which could help identify children in need of early intervention and help determine how to most effectively intervene to help these children fulfill their potential. The candidate has fully engaged a superb advisory team composed of mentors and consultants with complementary skill sets that reflect the interdisciplinary nature of her work. Primary mentor Dr. Stewart Mostofsky, co-mentor Dr. John Pruett and consultants Dr. Rebecca Landa, Joseph Piven, Kelly Botteron and Brian Caffo, are internationally-recognized scientists with a diverse range of expertise in ASD research, clinical care, infant development, developmental imaging science and statistics. Kennedy Krieger Institute has committed to supporting the candidate by providing the necessary laboratory space and financial resources needed to carry out the proposed research. This Mentored Research Scientist Development Award will provide the candidate with a critical training period to acquire knowledge and skills necessary to successfully implement the proposed research project and to develop an independent research career pursuing the interplay of early motor, visual and social skill development in ASD.

 描述（由申请人提供）：候选人是一名生物医学工程师，致力于开发神经影像和行为策略，以阐明导致自闭症谱系障碍 (ASD) 儿童运动和社交缺陷的发育机制。患有 ASD 的学龄儿童表现出特别的困难。任务依赖于手眼协调，并在学习新动作时表现出似乎是自闭症谱系障碍特有的视觉反馈折扣。此外，在第一年内可以观察到对运动发育的非特异性干扰。早期模仿行为主要取决于视觉-运动整合，与自闭症儿童随后的语言和游戏发展有关，并且是自闭症儿童的常见目标。因此，仔细检查运动缺陷，特别是视觉运动缺陷的出现对于自闭症谱系障碍至关重要，我们建议使用行为和脑成像方法来研究有自闭症谱系障碍风险的婴儿的视觉运动整合轨迹。进行在这项研究中，我们已经开始开发一种新的行为测量方法，用于测量婴儿在接球任务期间的视觉运动协调性，我们还将使用休息状态。 在自然睡眠期间收集功能连接 MRI (fcMRI) 数据，以提取同一婴儿的视觉运动整合的神经测量值。目标 1 和 2 的重点是从 AOSI 视频和编译的 fcMRI 数据中提取视觉运动功能的行为和神经测量值。我们将研究这些视觉运动整合的行为和神经测量的基线异常和发育轨迹是否对受影响的高危婴儿的功能结果有不同的预测。然后，探索性目标 3 将测试视觉运动整合的行为和神经测量是否可以预测个体对父母介导的干预的反应，使用视觉手动活动来针对社交模仿。自闭症谱系障碍（ASD）视觉运动异常的神经发育基础可以帮助将自闭症谱系障碍（ASD）分类为更容易处理的病症，这可以帮助识别需要早期干预的儿童，并帮助确定如何最有效地干预以帮助这些儿童发挥潜力。拥有一支由导师和顾问组成的优秀咨询团队，他们具有互补的技能，反映了她工作的跨学科性质，主要导师 Stewart Mostofsky 博士、联合导师 John Pruett 博士和顾问 Rebecca Landa 博士、Joseph Piven 和 Kelly 博士。 Botteron 和 Brian Caffo 是国际公认的科学家，在 ASD 研究、临床护理、婴儿发育、发育成像科学和统计学方面拥有广泛的专业知识，肯尼迪克里格研究所致力于通过提供必要的实验室空间来支持候选人。该导师研究科学家发展奖将为候选人提供关键的培训期，以获取成功实施拟议研究项目所需的知识和技能，并发展追求相互影响的独立研究生涯。自闭症谱系障碍 (ASD) 的早期运动、视觉和社交技能发展。