A role for vitamin D in drug addiction

维生素 D 在药物成瘾中的作用

基本信息

批准号：
8721039
负责人：
RALPH J DILEONE
金额：
$ 17.74万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-15 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8721039
关键词：
Adult Affect Amphetamines Amygdaloid structure Area Behavior Behavioral Brain Calcitriol Clinical Treatment Consumption Data Diet Dietary Component Dopamine Drops Drug Addiction Drug abuse Drug usage Eating Behavior Evaluation Food Gene Expression Genes Glucose Goals Health Surveys Hormones Illicit Drugs Institute of Medicine (U.S.)Intake Leptin Measures Mediating Metabolic Modeling Molecular Motivation Motor Activity National Health and Nutrition Examination Survey Nature Neural Pathways Neuraxis Neurons Neurophysiology - biologic function Nutrient Nutrition Surveys Obesity Oral Osteoclasts Pathway interactions Pharmaceutical Preparations Physiological Regulation Relapse Research Role Sampling Secosteroids Serum Signal Pathway Signal Transduction Silver Staging Steroid Receptors Stress Sunscreening Agents Surveys System Testing Therapeutic Time Vitamin D Vitamin D Deficiency Vitamin D3 Receptor Vitamins Work addiction base drug of abuse drug seeking behavior feeding food restriction interest mind body interaction neural circuit neuromechanism novel prevent public health relevance receptor receptor function release of sequestered calcium ion into cytoplasm research study response transcription factor

项目摘要

DESCRIPTION (provided by applicant): Caloric dietary components and metabolic hormones can act directly on the brain to influence neural function and relevant behaviors. While several of these signals (e.g. glucose and leptin) are known and studied, the effects of non-caloric dietary components, such as vitamins, are less studied. The fully active form of vitamin D (calcitriol), which functions as a secosteroid, can be derived from dietary vitamin D. The identification of vitamin D receptor (VDR) in dopamine centers in the brain raises the possibility that vitamin D levels can influence these areas. Specifically, it is hypothesized that behaviors affected by dopamine signaling, such as drug addiction, are affected by vitamin D signaling directly to these neurons. Preliminary data suggests that vitamin D levels can regulate gene expression of dopamine signaling genes, as well as behavioral responses to amphetamine, such as locomotor activity and oral consumption. The present application seeks to assess the specific role of VDR activity on these neurons in the context of dopamine release and signaling. Additionally, the potential therapeutic role of exogenous vitamin D will be evaluated in drug addiction paradigms. The proposed work is important for elucidating a novel role for a non-caloric dietary component, while also testing the therapeutic potential of vitamin D for treating drug addiction.

描述（由申请人提供）：热量饮食成分和代谢激素可以直接作用于大脑，影响神经功能和相关行为。虽然有几个这些信号（例如葡萄糖和瘦素）是已知的并已被研究，但对非热量饮食成分（例如维生素）的影响的研究较少。维生素 D（骨化三醇）的完全活性形式具有类固醇的作用，可以从膳食维生素 D 中提取。大脑多巴胺中枢中维生素 D 受体 (VDR) 的识别提出了维生素 D 水平影响这些功能的可能性。地区。具体来说，假设受多巴胺信号传导影响的行为（例如药物成瘾）会直接受到维生素 D 信号传导至这些神经元的影响。初步数据表明，维生素 D 水平可以调节多巴胺信号基因的基因表达，以及对安非他明的行为反应，例如运动活动和口服消耗。本申请旨在评估 VDR 活性在多巴胺释放和信号传导背景下对这些神经元的具体作用。此外，还将在药物成瘾范例中评估外源性维生素 D 的潜在治疗作用。这项工作对于阐明无热量饮食成分的新作用非常重要，同时还测试了维生素 D 治疗药物成瘾的治疗潜力。