Staying Strong and Healthy during Androgen Deprivation Therapy for Latino Men

拉丁裔男性在雄激素剥夺疗法期间保持强壮和健康

基本信息

批准号：
8650129
负责人：
SALLY L Maliski
金额：
$ 64.95万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-23 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8650129
关键词：
Accounting Achievement Address Adjuvant Adopted Adoption Adverse effects American Androgens Attention Awareness Behavior Blood Glucose Body mass index Bone Density Cardiovascular Diseases Cardiovascular system Cause of Death Center for Translational Science Activities Cessation of life Cholesterol Congestive Heart Failure Cutaneous Data Diabetes Mellitus Diagnosis Disease Dyslipidemias Eating Education Emotional Ethnic Origin Event Exercise Fatigue Fatty acid glycerol esters Food Glucose Goals Health Height High Density Lipoproteins Hip region structure Hispanics Hot flushes Hypertension Individual Intervention Interview Latino Lipids Los Angeles Low-Density Lipoproteins Malignant Neoplasms Malignant neoplasm of prostate Measures Mental Depression Metabolic Metabolic syndrome Methods Minority Modeling Monitor Morbidity - disease rate Myocardial Infarction Neoadjuvant Therapy Non-Insulin-Dependent Diabetes Mellitus Nurses Obesity Operative Surgical Procedures Osteoporosis Outcome Outcome Measure Participant Patients Perception Personal Communication Personal Satisfaction Physiological Prevention program Process Prostate Cancer Outcomes Study Prostate Cancer therapy Quality of life Radiation Radiation therapy Randomized Recruitment Activity Recurrence Relative (related person)Risk SF-12 Serum Sexual Dysfunction Site Stage at Diagnosis Staging Subgroup Techniques Telephone Testing Time Triglycerides United States Vasomotor Visceral Waist-Hip Ratio Weight Wife cancer diagnosis cardiovascular disorder risk comparison group depressive symptoms deprivation design diabetes risk fitness good diet group intervention health related quality of life high risk improved indexing interest men muscle form nutrition post intervention programs public health relevance theories treatment as usual

项目摘要

Androgen deprivation therapy (ADT) is increasingly being used to treat prostate cancer in the neoadjuvant and adjuvant contexts with radiation therapy (RT), for recurrence following primary treatment with surgery or radiation, or when the prostate cancer is at an advanced stage. This becomes highly significant considering that prostate cancer is the most commonly diagnosed noncutaneous cancer in American men. Of particular concern are Latino men, because Latinos are the fastest growing minority in the United States (US). Latino men are diagnosed with later stage disease making them more likely to be treated with ADT. Studies have shown that men on ADT are at increased risk for vasomotor symptoms, depression, fatigue, diminished health- related quality of life (HRQOL), decreased bone mineral density (BMD), sexual dysfunction, metabolic syndrome, increased fat mass, along with decreased lean muscle mass, increased serum lipids, and decreased arterial compliance all of which places them at higher risk for cardiovascular disease (CVD), osteoporosis, and type II diabetes. Latinos more often have obesity, dyslipidemia, low cardiovascular fitness, hypertension, and diabetes. Therefore, we propose to test our Staying Strong and Healthy program to promote healthy activity and nutrition during ADT for Latino men. Using a mixed methods design we aim to: 1. Compare pre- and post-intervention BMI, lipids, waist/hip circumference, and glucose within and between 75 Latino men starting ADT who are randomly assigned to receive the Staying Strong and Healthy intervention and 75 Latino men starting ADT randomly assigned to receive usual care. 2. Compare pre- and post- intervention HRQOL using the SF-12 subscales of emotional and physical well-being and disease-specific HRQOL using the Expanded Prostate Cancer Index Composite (EPIC) within and between groups. 3. Develop and compare explanatory models of Latino men's activity and nutrition choices between those receiving the intervention and those receiving usual care. 4. Evaluate acceptability and benefit of the intervention from perspective of participants. Latino men will be recruited form several sites serving predominantly Latino populations in Los Angeles. Men will come to UCLA Center for Translational Research for baseline, 6 and 12 months measures and interview at 12 months. Men assigned to the intervention group will receive initial assessment and education on nutrition and the exercised program immediately following baseline measures. They will then receive 12 weekly calls from a nurse coordinator/cultural liaison team to deliver focused information, establish individually tailored nutrition and activity goals, assess accomplishments of goals and provide support. We will conduct qualitative interview with 30 men from each group to assess the intervention from their perspective and to develop explanatory frameworks for decision process used relative to food and activity choices. Analysis will combine within and between group comparisons and grounded theory techniques.

雄激素剥夺疗法 (ADT) 越来越多地用于治疗前列腺癌的新辅助治疗和放射治疗 (RT) 的辅助治疗，用于手术或初次治疗后的复发放射，或当前列腺癌处于晚期时。考虑到这一点变得非常重要前列腺癌是美国男性中最常诊断出的非皮肤癌。特别是值得关注的是拉丁裔男性，因为拉丁裔是美国增长最快的少数族裔。拉丁裔男性被诊断出患有晚期疾病，这使得他们更有可能接受 ADT 治疗。研究有研究表明，接受 ADT 的男性出现血管舒缩症状、抑郁、疲劳、健康状况恶化的风险增加相关生活质量 (HRQOL)、骨矿物质密度 (BMD) 下降、性功能障碍、代谢综合症，脂肪量增加，瘦肌肉量减少，血脂增加，动脉顺应性降低，所有这些都使他们患心血管疾病（CVD）的风险更高，骨质疏松症和 II 型糖尿病。拉丁美洲人更常患有肥胖症、血脂异常、心血管健康水平较低、高血压、糖尿病。因此，我们建议测试我们的“保持坚强和健康”计划在 ADT 期间促进拉丁裔男性的健康活动和营养。使用混合方法设计，我们的目标是： 1. 比较干预前和干预后 BMI、血脂、腰围/臀围和血糖在 75 以内和之间的情况开始 ADT 的拉丁裔男性被随机分配接受“保持坚强和健康”干预 75 名开始 ADT 的拉丁裔男性被随机分配接受常规护理。 2. 前后对比使用情绪和身体健康以及特定疾病的 SF-12 子量表进行干预 HRQOL HRQOL 在组内和组间使用扩展前列腺癌综合指数 (EPIC)。 3. 开发并比较接受治疗的拉丁裔男性的活动和营养选择的解释模型干预和接受常规护理的人。 4. 评估干预措施的可接受性和益处参与者的观点。将从几个主要服务于拉丁裔的网站招募拉丁裔男性洛杉矶的人口。男性将来到加州大学洛杉矶分校转化研究中心进行基线、6 岁和 12 岁的研究个月的测量和 12 个月时的访谈。分配到干预组的男性将收到初步的在基线措施之后立即对营养和执行计划进行评估和教育。然后，他们每周将接到护士协调员/文化联络小组打来的 12 次电话，以提供有针对性的服务信息，制定个性化的营养和活动目标，评估目标的完成情况和提供支持。我们将对每组 30 名男性进行定性访谈，以评估干预措施从他们的角度出发，并为与食品和食品相关的决策过程制定解释性框架活动选择。分析将结合组内和组间比较以及扎根理论技术。