Compensatory Neural Networks for the Cognitive Control of Emotion in Youth at Risk for Bipolar Disorder

用于双相情感障碍青少年情绪认知控制的补偿神经网络

基本信息

批准号：
9913583
负责人：
Danella Marie Hafeman
金额：
$ 18.68万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-18 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9913583
关键词：
14 year old Adolescent Adult Affective Age Amygdaloid structure Area Back Bipolar Disorder Brain Brain region Child Childhood Clinical Collaborations Data Development Diagnosis Early Intervention Educational workshop Emotions Faculty Family Financial compensation Future Goals Individual Individual Differences Institution Instruction Intervention Knowledge Lateral Lead Longitudinal Studies Mediating Mental Depression Mental disorders Mentors Mentorship Meta-Analysis Methods Mood Disorders Moods Neurosciences Onset of illness Outcome Parents Pattern Phenotype Population Prefrontal Cortex Preventive Preventive measure Principal Investigator Psychiatrist Psychopathology Research Research Activity Research Personnel Resources Rest Risk Sampling Scanning Selection Criteria Short-Term Memory Signal Transduction Testing Time Training Training Activity Training Programs Universities Vulnerable Populations Work Youth affective neuroscience base behavior measurement career development childhood bipolar disorder cognitive ability cognitive control cognitive neuroscience cognitive reappraisal design disorder risk early adolescence emotion dysregulation emotion regulation emotional stimulus habituation improved negative affect neural circuit neural correlate neural network neurodevelopment neuroimaging neuromechanism novel offspring prevent recruit reduce symptoms relating to nervous system resilience response skills statistics success

项目摘要

PROJECT SUMMARY / ABSTRACT Offspring of parents with bipolar disorder (“at-risk youth”) are at increased risk for the development of psychopathology. Many of these at-risk youth have elevated mood lability, frequent and severe changes in mood state, which contributes to poor functioning and increases risk for mood disorder. However, not all individuals at familial risk develop psychiatric disorders, and in this project we explore the compensatory networks that could help to explain individual differences in risk. Several lines of evidence indicate that neural circuitry supporting working memory (WM) might act as such a compensatory network, and that better working memory capacity (WMC) in particular is associated with better emotion regulation and less mood lability. The objective of this project is to better understand the neural circuitry of mood lability, and to then assess potential compensatory neural mechanisms in youth at risk for bipolar disorder (BD). We propose to first assess differences between at-risk and healthy youth in the activation and functional connectivity (FxC) of ventral networks involved in cognitive reappraisal of emotion, and whether the individual differences in these networks correlate with degree of mood lability in the at-risk youth. We next evaluate if a greater WMC (and FxC of the central executive network, central to WM) might compensate for these ventral abnormalities, and thus might be associated with less mood lability in at-risk youth. To provide a probe of the directionality of this relationship, we conduct a pilot manipulation of WM training (5 weeks) in a subset of at-risk, labile youth. Identification of such a compensatory network in at-risk youth would provide a target for preventive measures in these youth, and pave the way for future studies investigating strategies for building resilience. In concert with this research plan, training goals will provide the Principal Investigator with a skillset necessary to further pursue this line of research: specifically, training in developmental cognitive neuroscience, the implementation of neuroimaging studies in pediatric populations, and sophisticated analysis of neuroimaging data. To obtain this training, the PI has assembled a mentorship team with expertise in relevant areas, most notably, her mentor Dr. Mary Phillips (neuroimaging in BD) and co-mentor Dr. Boris Birmaher (implementation of studies of youth with BD). She has also designed a detailed training plan, which includes formal collaborations with consultants, coursework, and workshops. Research and training activities will primarily occur at the University of Pittsburgh, an institution with a commitment to research in pediatric BD, as well as affective and cognitive neuroscience, and a strong track record for supporting the career development of junior faculty. This training will build on the PI’s existing background as a child psychiatrist with a strong knowledge of statistics and clinical neuroscience, to provide her will the necessary skills to become an independent investigator. Her long-term research goal is to better characterize the neurodevelopmental trajectory of BD in youth, and develop strategies for building resilience in those who are at risk for disorder.

项目摘要 /摘要躁郁症父母的后代（“处于危险年轻人”）的发展风险增加心理病理学。这些高风险的青年中有许多人的情绪劳动升高，经常和严重的变化情绪状态，导致功能不佳并增加了情绪障碍的风险。但是，不是全部家庭风险发展精神疾病的个人，在这个项目中，我们探索了补偿性可以帮助解释风险中个体差异的网络。几条证据表明中立支持工作记忆（WM）的电路可能充当这样的补偿网络，并且更好地工作尤其是记忆能力（WMC）与更好的情绪调节和更少的情绪劳动有关。这该项目的目的是更好地了解情绪不稳定的神经元电路，然后评估潜力躁郁症风险（BD）的年轻人的补偿性神经机制。我们建议首次评估在腹侧激活和功能连通性（FXC）中，处于危险和健康青年之间的差异参与情绪认知重新评估的网络，以及这些网络中的个体差异是否存在与高危青年的情绪不稳定程度相关。接下来，我们评估是否有更大的WMC（和FXC 中央执行网络，WM的中心）可能会弥补这些腹侧异常，因此可能是与高危青年的情绪不稳定相关。为了探究这种关系的方向性，我们对处于危险，不稳定的青年的子集进行了WM培训（5周）的试点操纵。识别这种高风险青年的补偿网络将为这些青年的预防措施提供目标，并为未来的研究铺平了道路研究建筑弹性的策略。与该研究计划一致，培训目标将为首席研究人员提供技能进一步购买这一研究的必要条件：特别是在发展认知神经科学方面的培训，在儿科人群中的神经影像学研究的实施，以及对神经影像数据。为了获得这项培训，PI与相关方面的专家组成了一支精通团队最值得注意的是她的精神玛丽·菲利普斯（Mary Phillips）博士（BD神经影像）和鲍里斯·伯玛赫（Boris Birmaher）博士（实施BD青年研究）。她还设计了一个详细的培训计划，其中包括与顾问，课程和研讨会的正式合作。研究和培训活动将首先是在匹兹堡大学（University of Pittsburgh），该机构致力于儿科BD研究，以及情感和认知神经科学，以及支持职业发展的良好记录初级教师。这项培训将以PI为儿童精神病医生的现有背景为基础了解统计和临床神经科学的知识，为她提供必要的技能，成为独立研究者。她的长期研究目标是更好地描述神经发育 BD在青年中的轨迹，并制定有疾病风险的人建立韧性的策略。