2020 Bones and Teeth Gordon Research Conference and Gordon Research Seminar

2020年骨骼与牙齿戈登研究会议暨戈登研究研讨会

• 批准号: 9913185
• 负责人: Vicki Rosen
• 金额: $ 2.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2021-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913185
• 关键词: Adult; Aging; Atmosphere; Biology; Chronology; Collaborations; Data; Degenerative polyarthritis; Development; Developmental Biology; Disabled Persons; Disease; Embryo; Emerging Technologies; Endocrinology; Environment; Event; Extracellular Matrix; Failure; Fostering; Fracture; Goals; Healthcare; Homeostasis; Institutes; Knowledge; Life; Malignant Bone Neoplasm; Mentorship; Mission; Molecular Genetics; Morbidity - disease rate; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; Natural regeneration; Organ; Osteoporosis; Participant; Pathology; Periodontitis; Physiology; Postdoctoral Fellow; Research; Research Personnel; Research Support; Scientist; Shapes; Signal Transduction; Site; Skeletal Development; Skeleton; Structure; Students; Therapeutic; Time; Tissues; Tooth structure; Travel; Underrepresented Minority; United States National Institutes of Health; Woman; Work; bone; career; career development; clinically relevant; combat; craniofacial; design; meetings; mortality; next generation; novel therapeutic intervention; posters; programs; repaired; response; skeletal; skeletal tissue; stem cell biology; stem cells; symposium; therapeutic development

PROJECT SUMMARY For more than 60 years, the Gordon Research Conference on Bones & Teeth (B&T GRC) has distinguished itself as a forum for the exchange of cutting-edge ideas on the physiology and pathology of bone, bone-related tissues and teeth (herein referred to as the skeleton). In the past decade, the Gordon Research Seminar (GRS) held one day before the GRC and focused on participation of trainees and early career investigators has promoted close interactions between next-generation scientists and senior investigators. The 2020 B&T GRC and GRS will continue and strengthen this tradition. Through structured scientific presentations, formal and informal discussions, and highly interactive poster sessions held over the course of 6 days (1day GRS plus 5 days GRC), the meetings are designed to showcase the latest scientific discoveries and to catalyze cross-disciplinary collaborations. Despite impressive advances in our understanding of the cellular, molecular and genetic mechanisms governing normal skeletal development and homeostasis, diseases of the skeleton, including osteoporosis, osteoarthritis, fracture repair failure, bone cancer, and periodontitis continue to be major contributors to adult morbidity and mortality. By bringing together experts in signal transduction, extracellular matrix (ECM) biology, stem cell biology, developmental biology, molecular genetics, physiology, endocrinology, aging, and emerging technologies, the 2020 B&T GRC hopes to capture the tremendous momentum and progress in the field, inspire new research directions, and foster new collaborations aimed at advancing therapeutic development in the skeletal arena. The theme of the 2020 B&T GRC is The Life of the Skeleton. Starting with an introduction to signaling circuits, stem cells, and ECM, we examine the events directing skeletal homeostasis in chronological order, and at specific temporal inflection points compare and contrast the appendicular, axial and craniofacial skeletal responses. We also discuss emerging technologies that allow us to investigate skeletal biology in new ways, and end our meeting by focusing on whether repair/regeneration of adult skeletal tissues is a return to principles that govern embryonic skeletal development, or representative of a new stage of skeletal biology, a controversial topic vital to development of successful therapeutic approaches in the adult skeleton. Both the scientific content and the collaborative spirit of the GRC and GRS are directly aligned with the missions of multiple NIH institutes including NICHD, NIDCR, NIA, and NIAMS.

项目概要 60 多年来，戈登骨骼与牙齿研究会议 (B&T GRC) 一直在 本身作为骨生理学和病理学、骨相关前沿思想交流的论坛 组织和牙齿（本文称为骨骼）。过去十年，戈登研究研讨会 (GRS) 在 GRC 前一天举行，重点关注学员和早期职业调查员的参与 促进了下一代科学家和高级研究人员之间的密切互动。 2020 年 B&T GRC和GRS将继续并加强这一传统。通过结构化的科学演示，正式 为期 6 天的非正式讨论和高度互动的海报会议（1 天 GRS 加上 5 天的 GRC），会议旨在展示最新的科学发现并促进 跨学科合作。尽管我们对细胞、分子的理解取得了令人印象深刻的进步 和控制正常骨骼发育和稳态、骨骼疾病的遗传机制， 包括骨质疏松症、骨关节炎、骨折修复失败、骨癌和牙周炎继续受到关注 成人发病率和死亡率的主要因素。通过汇集信号转导领域的专家， 细胞外基质（ECM）生物学、干细胞生物学、发育生物学、分子遗传学、生理学、 内分泌学、衰老和新兴技术，2020 年 B&T GRC 希望捕捉到巨大的成果 该领域的势头和进展，激发新的研究方向，并促进旨在实现新的合作 推进骨骼领域的治疗发展。 2020年B&T GRC的主题是The Life of the 骨骼。首先介绍信号回路、干细胞和 ECM，我们研究这些事件 按时间顺序指导骨骼稳态，并在特定的时间拐点进行比较和 对比四肢、轴向和颅面骨骼反应。我们还讨论新兴技术 这使我们能够以新的方式研究骨骼生物学，并通过关注是否 成人骨骼组织的修复/再生是对控制​​胚胎骨骼的原则的回归 发展，或代表骨骼生物学的新阶段，一个对发展至关重要的有争议的话题 成人骨骼的成功治疗方法。既有科学内容，又有协作精神 GRC 和 GRS 的职责与多个 NIH 机构的使命直接相关，包括 NICHD、NIDCR、 NIA 和 NIAMS。