Amazonian Center of Excellence in Malaria Research

亚马逊疟疾研究卓越中心

• 批准号: 9911980
• 负责人: Joseph M. Vinetz
• 金额: $ 136.68万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9911980
• 关键词: Acute; Address; Adult; Anopheles Genus; Biological; Biological Assay; Biology; Brazil; Breeding; Cells; Clinical; Computer software; Culicidae; Data; Data Analyses; Data Collection; Databases; Demographic Analyses; Development; Dictionary; Disease; Ecology; Ensure; Entomology; Epidemiology; Falciparum Malaria; Feeding behaviors; Feeds; Funding; Future; Genbank; Genetic; Genomics; Geography; Goals; Habitats; Health; Heterogeneity; Human; Immune; Immune response; Immunity; Immunologic Markers; Immunologics; Immunology; Incidence; Infection; Inflammation; Infrastructure; Innate Immune Response; Institution; Intervention; Laboratories; Legal patent; Longitudinal cohort; Malaria; Membrane; Metadata; Microscopy; Modification; Molecular Epidemiology; Pan American Health Organization; Parasitemia; Parasites; Patients; Pattern; Peru; Peruvian; Plasmodium; Plasmodium falciparum; Plasmodium vivax; Policies; Population; Preparation; Prevalence; Protocols documentation; Public Health; Regulation; Research; Research Design; Residual state; Sampling; Secure; Seminal; Signs and Symptoms; Site; Standardization; Surveys; Tablets; Testing; Time; Training; Vector Ecology; Work; base; biosignature; data management; data quality; data standards; design; experimental study; feeding; interdisciplinary approach; interest; international center; longitudinal dataset; malaria infection; malaria transmission; mathematical model; meetings; novel; novel strategies; population based; programs; prospective; sociodemographics; spatiotemporal; statistics; tool; transmission process; vector; vector competence; vector transmission

The overall research aim of the Amazonian International Center of Excellence in Malaria Research is to organize a comprehensive approach to understanding the biological features of Amazonian malaria towards the ultimate goal of regional control and elimination of Plasmodium falciparum and P. vivax. While in the past the Amazonian ICEMR focused primarily on P. vivax because of its greater impact in the region, given recent developments in both Brazil and Peru, P. falciparum will also be a focus of our work. At the national level in Brazil, the national malaria control program has made P. falciparum a primary focus of elimination efforts, as P. falciparum malaria remains highly prevalent in the Juruá Valley in western Brazilian Amazonia. In Peru, after the cessation of Global Fund-supported malaria control efforts in 2010, P. falciparum has reemerged as an important public health threat. The Amazonian ICEMR's recent meetings with the Loreto Ministry of Health witnessed the high level of concern about this re-emergence and the Ministry's interest in harnessing the Amazonian ICEMR's research strengths to addressing this emergent and timely issue. Overall, we anticipate that the lessons learned will contribute towards the audacious goal of global malaria eradication. The Amazonian ICEMR has 5 epidemiologically distinct malaria-endemic sites in Brazil and Peru. Project 1 focuses on malaria epidemiology and takes multidisciplinary approaches to study distinct transmission patterns in the Brazilian and Peruvian malaria-endemic sites using socio-demographic analysis, molecular epidemiology and genomics, and mathematical modeling to integrate all three ICEMR Projects, including Project 2, which focuses on vector ecology and transmission biology, and Project 3, which focuses on immunological mechanisms of asymptomatic parasitemia and clinical immunity, and to discover biosignatures of clinically immune (asymptomatic parasitemia) vs non-immune (acute, symptomatic malaria). Our long-term goal is to develop the scientific underpinnings of novel elimination strategies to be deployed in Amazonia, with broad generalizability to other malaria-endemic regions. This proposed Center therefore takes on a comprehensive approach to malaria research in the Peruvian and Brazilian Amazon, which will be used to inform Ministries of Health in Brazil and Peru, and officials of the Pan American Health Organization and the Amazonian Malaria Initiative, of new approaches to develop malaria elimination policies based on scientific data.

亚马逊国际疟疾研究中心的总体研究目的是。 组织一种全面的方法来理解亚马逊疟疾的生物学特征 过去的区域控制和消除疟原虫的最终目标。 鉴于最近 巴西和秘鲁，恶性疟原虫的发展也将成为我们的焦点。 巴西，国家疟疾控制计划使恶性疟原虫成为消除努力的主要重点，如P. 恶性疟疾在秘鲁西部的尤鲁亚山谷中仍然很普遍 2010年，全球拟福利基金支持的疟疾控制工作的停止，恶性疟原虫已重新出现为 重要的公共卫生线程。 目睹了对这种重新出现的高度关注以及该部对利用您的兴趣 亚马逊ICEMR的研究实力能够实现这一新出现和及时的问题。 所学的教训将有助于大胆的消除疟疾的目标。 亚马逊ICEMR在巴西和秘鲁有5个流行病学上不同的疟疾 - 疟疾 专注于疟疾流行病学，并采用多学科的方法来研究独特的传播 使用社会人口统计学分析，巴西和秘鲁疟疾 - 流行部位的模式 流行病学和基因组学以及数学建模，以整合所有三个ICEMR项目，包括 项目2，侧重于矢量生态学和传播生物学，以及项目3，重点介绍 无症状寄生虫血症和临床IMUNITY的免疫学机制，并发现 临床免疫（无症状寄生虫血症）与非iMune的生物签名（急性，有症状 疟疾）。我们的长期目标是发展新颖的消除策略的科学基础 在亚马逊地区部署，对其他疟疾流行区域有广泛的概括 因此 它将用于告知巴西和秘鲁的卫生部，以及泛美卫生的官员 组织和亚马逊疟疾倡议是开发疟疾Elaria消除的新方法 基于科学数据的政策。