Brain Rehabilitation Research Center

脑康复研究中心

• 批准号: 9910074
• 负责人: RUSSELL M BAUER
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910074
• 关键词: Achievement; Affect; Age; Animal Model; Attention; Award; Benchmarking; Biological Markers; Brain; Brain imaging; Budgets; Caring; Chronic; Clinical; Cognition; Cognitive; Diagnosis; Disease; Emotional; Emotions; Equipment; Ethnic Origin; Etiology; Feedback; Florida; Fright; Funding; Gait; Gender; Goals; Health; Health system; Healthcare; Healthcare Systems; Hospitals; Human; Impaired cognition; Inflammatory; Institution; Interdisciplinary Study; Intervention; Leadership; Locomotor training; Long-Term Care; Measurement; Measures; Memory; Memory impairment; Mentors; Mission; Motor; Nervous System Trauma; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Neurosciences; Organizational Models; Pathologic; Pathology; Performance; Personal Satisfaction; Post-Traumatic Stress Disorders; Process; Protocols documentation; Psychotherapy; Quality of life; Race; Recovery; Regimen; Rehabilitation therapy; Research; Research Personnel; Resource Sharing; Resources; Rodent Model; Role; Science; Self Efficacy; Services; Strategic Planning; Stroke; Structure; Survivors; Testing; Time; Training; Traumatic Brain Injury; Universities; Upper Extremity; Upper limb movement; Veterans; Walking; career; central nervous system injury; chronic stroke; clinical practice; clinically translatable; cognitive recovery; cohesion; comorbidity; comparative effectiveness trial; cost; cost effective; cost estimate; disability; emotion regulation; executive function; falls; functional restoration; gait rehabilitation; genetic variant; human model; improved; innovation; motor recovery; multiple disability; nervous system disorder; neural network; neurological rehabilitation; neurophysiology; novel; persistent symptom; post stroke; pre-clinical; program dissemination; programs; rehabilitation research; relating to nervous system; response; sensory feedback; stroke intervention; stroke survivor; stroke therapy

The Mission of the Brain Rehabilitation Research Center (BRRC) is: Maximize recovery of cognitive, emotion, and motor function in Veterans affected by neurologic injury or disease by potentiating neural plasticity and neural network reorganization through the discovery of mechanisms and innovation of treatments. The BRRC is a 19-yr consortium with three major institutions: North Florida/South Georgia VA Health Care System, University of Florida (UF)/Shands Healthcare, and Brooks Rehabilitation Hospital. The BRRC supports > 28 investigators (14 PIs with VA-funded studies, 14 associate investigators, and additional collaborating investigators) and their teams. The BRRC supports a collaborative, interdisciplinary research team, providing extensive facilities and resources for sophisticated human performance and brain function measurement. Our planned research programs utilize specific neuroplastic mechanisms to recover cognitive, emotion, and motor function. First, in the Cognition Function Initiative, we are developing innovative treatment for impaired memory, executive function, and goal achievement in TBI survivors. Second, in the Emotion Function Initiative, we are establishing new brain neuromarkers for objective diagnosis of PTSD and prediction of psychotherapy response in the presence and absence of TBI. We are investigating the etiological, pathological and neurophysiological mechanisms of PTSD comorbid with TBI, identifying brain networks involved in the emotional consequences of PTSD/TBI, and testing novel interventions to aid in recovery of emotion regulation. Third, in the Motor Function Initiative, we are investigating brain activation mechanisms during walking and during upper limb movement, to elucidate pathology and identify more useful treatment targets for inducing motor recovery. We are developing and feasibility-testing a new brain neural feedback regimen (real time brain imaging) to improve upper limb function after stroke. We are testing several innovative gait training interventions for stroke survivors: combination of gait coordination and brain stimulation; backward walking training paradigm; enhancing sensory feedback during walking and testing emotional fear factors related to fall self-efficacy; and feasibility-testing a protocol for a comparative effectiveness trial, for long-term mobility and health for chronic stroke. Fourth, in the Rehabilitation Neuroscience Initiative (animal and human models), we are refining our preclinical rodent models of TBI and SCI that reflect clinical symptoms of chronic and persistent disabilities in human TBI/SCI. We are establishing reliable, quantitative, and clinically translatable measures for assessing chronic multiple disabilities and for illuminating the role of TBI in chronic human neurodegenerative disease. We are evaluating efficacy of combined interventions, such as locomotor training and CNS stimulation, to mitigate TBI-induced disabilities. In stroke and TBI separately, we are evaluating the impact of potential modifiers such as age, gender, race/ethnicity, and moderating biomarkers of gene variants, brain structure/function, and inflammatory processes on cognitive impairment. The BRRC has consistently achieved the benchmarks expected by the RR&D Service, as follows: * Thematically cohesive, neural plasticity research portfolio focused on RR&D high priority Veteran needs for those with neurological injury or disease. * Robust science dissemination program, including national leadership by BRRC investigators. * Active and successful capacity-building program, including support and mentoring across career stages. * Excellent funding leverage ratio of Core Center award. * Acquisition and stewardship of extensive facilities, equipment, and shared resources for investigators. * Successful organizational model with a track record of strongly supporting investigators, inclusive budget planning process, visionary strategic planning process.

大脑康复研究中心（BRRC）的任务是： 最大化受神经损伤影响的退伍军人的认知，情感和运动功能的恢复 通过发现神经可塑性和神经网络的重组，通过发现 治疗机制和创新。 BRRC是一个19岁的财团，拥有三个主要机构：北佛罗里达州/佐治亚州南部弗吉尼亚州卫生保健 系统，佛罗里达大学（UF）/Shands Healthcare和Brooks Rehabilitation Hospital。 BRRC 支持> 28位研究人员（14个PI，由VA资助的研究，14位副研究人员和其他 合作调查人员）及其团队。 BRRC支持一项协作，跨学科研究 团队，为复杂的人类绩效和大脑功能提供广泛的设施和资源 测量。我们计划的研究计划利用特定的神经塑性机制来恢复认知， 情绪和运动功能。首先，在认知功能倡议中，我们正在开发创新治疗 在TBI幸存者中，记忆力受损，执行功能和目标成就。第二，情感 功能倡议，我们正在建立新的大脑神经标志物，以实现PTSD的客观诊断和预测 在存在和不存在TBI的情况下，心理治疗反应的。我们正在研究病因， PTSD合并与TBI的病理和神经生理机制，识别脑网络 参与PTSD/TBI的情感后果，并测试新颖的干预措施以帮助恢复 情绪调节。第三，在运动功能计划中，我们正在研究大脑激活机制 在步行和上肢运动期间，阐明病理学并确定更有用的治疗方法 诱导运动恢复的目标。我们正在开发和可行性测试新的大脑神经反馈 方案（实时脑成像）以改善中风后上肢功能。我们正在测试几个 中风幸存者的创新步态训练干预措施：步态协调和大脑刺激的结合； 向后步行训练范式；在步行和测试情绪恐惧期间增强感觉反馈 与跌倒自我效能有关的因素；并为比较有效性试验的方案进行可行性测试，用于 慢性中风的长期流动性和健康。第四，在康复神经科学倡议中（动物 和人类模型），我们正在完善反映临床症状的TBI和SCI的临床前啮齿动物模型 人类TBI/SCI中的慢性残疾和持续残疾。我们正在建立可靠，定量和临床 可翻译的措施，用于评估慢性多重残疾和阐明TBI在慢性中的作用 人神经退行性疾病。我们正在评估合并干预措施的功效，例如运动 训练和中枢神经系统刺激，以减轻TBI诱发的残疾。在中风和TBI中，我们是 评估年龄，性别，种族/种族等潜在修饰符的影响，并调节生物标志物 基因变异，大脑结构/功能以及认知障碍的炎症过程。 BRRC始终达到了RR＆D服务期望的基准，如下所示： *主题性凝聚力，神经可塑性研究组合的重点是RR＆D高优先级的资深需求 患有神经损伤或疾病的人。 *强大的科学传播计划，包括BRRC调查人员的国家领导。 *积极而成功的能力建设计划，包括跨职业阶段的支持和指导。 *核心中心奖的优质资金杠杆比率。 *为调查人员获得广泛的设施，设备和共享资源的收购和管理。 *成功支持调查人员，包容性预算的成功组织模型 计划过程，远见的战略规划过程。