PSYCHOPHYSIOLOGY OF IMPLICIT MEMORY IN ALCOHOLIC AMNESIA

酒精性遗忘症中内隐记忆的心理生理学

• 批准号: 2043401
• 负责人: RUSSELL M BAUER
• 金额: $ 11.36万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-29 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2043401
• 关键词: Alzheimer's disease; Huntington's disease; alcoholic psychosis; alcoholism /alcohol abuse; autonomic nervous system; dementia; electrodes; galvanic skin response; human subject; intelligence tests; memory disorders; neuropsychological tests; neuropsychology; performance; psychophysiology; silver chloride electrode; statistics /biometry; toxicology

Recent neuropsychological and cognitive-psychological research with normals and brain-damaged subjects has indicated that overt processes of stimulus identification can be dissociated from covert processes of stimulus recognition. Several studies have revealed positive evidence of covert recognition (e.g., autonomic discrimination, rudimentay lexical categorization) in the absence of overt verbal identification. This suggests that there are covert aspects of information-processing which are neither directly nor accurately reflected in verbal report data. The overall objective of the proposed research is to determine whether similar dissociations characterize the memory-recognition performance of alcoholic amnesics and three groups of controls. It is known that alcoholic amnesics show memory benefit ("savings") in repeated presentations of tasks they do not overtly remember previously performing. In this context, the purpose of the proposed studies is to determine whether such patients can covertly "recognize" learned material that they have overtly forgotten. This will be approached by studying dissociations and correlations between autonomic and verbal recognition indices in alcoholic Korsakoff patients, nonalcoholic amnesics, long-term alcoholics, and normal controls. Four paradigms widely used in memory research (simple recognition, rate-of-forgetting, temporal-gradient remote memory assessment, and levels-of-processing) will be employed to study the relationship between verbal and autonomic (i.e., electrodermal) indices of recognition under differing conditions. If it is the case that, in alcoholic Korsakoff patients and controls, autonomic evidence of learning occurs in the absence of overt verbal report, then several critical issues are raised. First, amnesic failures in memory paradigms may be more related to deficits in demonstrating knowledge than to having knowledge about learned stimuli. Second, the question, "does the patient remember" may be answered in different ways depending upon which response system is used to index memory performance. Third, the relationship between covert and overt recognition indices will have to be accounted for in theoretic models of amnesic memory defects.

最近与正常的神经心理学和认知心理学研究 大脑受损的受试者表明刺激的明显过程 识别可以与刺激的秘密过程分离 认出。 几项研究揭示了秘密的积极证据 识别（例如，自主歧视，Rudimentay词汇 分类）在没有明显的言语识别的情况下。 这 表明信息处理的秘密方面是 口头报告数据中既不直接也不准确地反映。 这 拟议研究的总体目标是确定是否相似 分离表征了酒精的记忆识别性能 健忘症和三组对照。 众所周知，酗酒的失忆症 在重复演示他们执行的任务中显示内存益处（“储蓄”） 不公开记住以前的表现。 在这种情况下，目的 拟议的研究是确定此类患者是否可以秘密 “认识”他们公开忘记的材料。 这会 可以通过研究自主神经之间的分离和相关性来接近 和酒精korsakoff患者的言语识别指数， 非酒精性健忘症，长期酗酒和正常对照。 四个 广泛用于记忆研究的范例（简单识别， 遗产率，时间梯度遥控内存评估和 处理水平）将用于研究 言语和自主神经（即电甲型）识别指数 不同的条件。 如果是这种情况，在酗酒的科萨科夫 患者和对照，在缺席的情况下，学习的自主性证据发生 在公开的口头报告中，提出了几个关键问题。 第一的， 记忆范例中的失败失败可能与缺陷有关 展示知识而不是拥有有关学习刺激的知识。 其次，问题是“病人记住了” 根据使用哪个响应系统索引内存的不同方式 表现。 第三，秘密和公开认可之间的关系 必须在健忘记忆的理论模型中考虑索引 缺陷。