A turnkey research platform to accelerate clinical translation of focused-ultrasound (FUS) oncology therapies

加速聚焦超声 (FUS) 肿瘤疗法临床转化的交钥匙研究平台

• 批准号: 9908739
• 负责人: Ryan Gessner
• 金额: $ 30万
• 依托单位: SONOVOL, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9908739
• 关键词: 3-Dimensional; Ablation; Acceleration; Acoustics; Address; Algorithms; Animal Model; Animals; Area; Basic Science; Breast Cancer Model; Clinic; Clinical; Collaborations; Complex; Computer software; Coupling; Data; Detection; Development; Devices; Dose; Drug Delivery Systems; Engineering; Ensure; Equipment; Focused Ultrasound; Focused Ultrasound Therapy; Foundations; Frequencies; Image; Immunization; Immunologist; Immunology; Immunotherapy; In Vitro; Industry; Institution; Location; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measures; Modality; Monitor; Neurology; Operative Surgical Procedures; Output; Pharmaceutical Preparations; Phase; Physicians; Radiation; Reproducibility; Research; Research Personnel; Robotics; Rodent Model; Scanning; Site; Standardization; Surgical incisions; Surveys; System; Techniques; Technology; Temperature; Testing; Therapeutic; Therapeutic Human Experimentation; Thermal Ablation Therapy; Thermometry; Three-Dimensional Image; Tissues; Traction; Transducers; Translations; Ultrasonic Transducer; United States National Institutes of Health; Validation; Work; anti-cancer therapeutic; anticancer treatment; base; cancer therapy; clinical application; clinical translation; clinically translatable; commercialization; experimental study; flexibility; follow-up; image guided; in vivo; innovation; mouse model; new technology; novel; oncology; pre-clinical; pressure; research and development; software development; sonoporation; tool; treatment planning; treatment strategy

Abstract Focused ultrasound (FUS) is an early-stage, noninvasive therapeutic technology with great potential in oncology. FUS could potentially offer either an alternative or complementary strategy to existing cancer treatment approaches such as surgery, radiation, and immunotherapy. While FUS technology has some initial traction, there are still many unknowns about how best to deliver FUS and mechanisms of action. The work proposed herein will result in a platform that will accelerate the translational pace of this promising treatment modality. SonoVol is proposing to build and validate a novel FUS guidance, treatment, and assessment platform for small animals. The system will be deployed in SonoVol’s Vega, a robotically controlled volumetric scanning device for high-throughput preclinical imaging. Unlike conventional FUS research solutions, the new 3D image guided “TherUS” Platform will ensure accurate and repeatable FUS dose delivery irrespective of user or sonographer expertise. TherUS will accelerate FUS clinical translation by lowering the technological barriers which limit widespread access, putting the technology directly in the hands of the broader market of cancer biologists and immunologists to develop cutting-edge anticancer treatment strategies, including immunotherapy approaches. This work will proceed via three stages. First, we will develop hardware to allow accurate and repeatable dose delivery via multiple FUS transducers within the same study. Two transducers with center frequencies of 0.5 and 2 MHz will be installed in a robotic carriage and the pressure fields will be mapped to allow spatial localization with the guidance and follow up transducers. Second, we will develop software to facilitate treatment planning and confirmation of dose delivery. We will create a module to allow registration to previous timepoints, as well as dose confirmation algorithms within SonoVol’s software for thermometry and cavitation detection. Finally, we will compare accuracy, repeatability, and reproducibility of TherUS against a conventional top-down FUS system and prove in vivo feasibility with an ablation study in a mouse model of breast cancer.

抽象的 专注超声（FUS）是一种早期，无创的治疗技术，具有很大的潜力 肿瘤学。 FUS可能会为现有癌症提供替代或完整的策略 治疗方法，例如手术，放射和免疫疗法。虽然FUS技术有一些初始 牵引力，关于如何最好地提供FUS和作用机理仍然有许多未知数。工作 本文提出的将导致一个平台，该平台将加速这种承诺治疗的转化空间 方式。 Sonovol提议建立和验证新型的FUS指导，治疗和评估 小动物的平台。该系统将部署在Sonovol的Vega，这是一个由机器人控制的体积 高通量临床前成像的扫描装置。与传统的FUS研究解决方案不同，新的 3D图像指导的“ Therus”平台将确保准确且可重复的FUS剂量交付 用户或超声波专业知识。 Therus将通过降低技术来加速FUS临床翻译 限制宽度访问的障碍，将技术直接掌握在更广阔的市场中 癌症生物学家和免疫学家制定尖端的抗癌治疗策略，包括 免疫疗法方法。这项工作将通过三个阶段进行。首先，我们将开发硬件以允许 在同一研究中，通过多个FUS传感器进行准确且可重复的剂量递送。两个传感器 中心频率为0.5和2 MHz将安装在机器人载体中，压力场将是 映射以允许在指导和后续换能器中进行空间定位。第二，我们将发展 软件以促进治疗计划和剂量递送的确认。我们将创建一个模块以允许 注册以前的时间点，以及Sonovol软件中的剂量确认算法 温度计和空化检测。最后，我们将比较准确性，可重复性和复制 反对常规自上而下的FUS系统的Therus，并通过一项消融研究证明了体内可行性 乳腺癌的小鼠模型。