Development of a nanotechnology resource center to advance urological research

开发纳米技术资源中心以推进泌尿外科研究

• 批准号: 9913112
• 负责人: KELVIN P DAVIES
• 金额: $ 33.4万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-17 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913112
• 关键词: Address; Basic Science; Benign; Biomedical Research; Clinical; Clinical Research; Collaborations; Communities; Development; Diagnosis; Drug Delivery Systems; Drug Targeting; Extramural Activities; Formulation; Funding; Genitourinary system; Goals; Image; Institution; Laboratory Research; Lead; Learning; Licensing; Medical; Modality; Nanotechnology; Pathology; Positioning Attribute; Process; Property; Publications; Research; Research Personnel; Research Project Grants; Resource Allocation; Resource Development; Resources; Role; System; Technology; Therapeutic; Tissues; Training; Urogenital Diseases; Urologic Diseases; Urology; design; improved; interest; nanoparticle; nanoparticle delivery; new technology; novel; programs; synergism; urologic

Abstract Novel technologies facilitate breakthroughs in scientific discovery with concomitant advances in therapy. In the case of nanotechnology, a major focus has been on optimizing its use for targeted drug delivery, imaging, diagnosis, or a combination of therapeutics and diagnosis (“theranosis”). However, the application of nanotechnology in the research and treatment of benign urological pathologies remains underexplored. At our institution (“Einstein”), the research laboratory of Dr. Joel Friedman has developed a nanoparticle- delivery system (the “Einstein” nanoparticle). We and others have applied this system to multiple research fields, including benign urology, as documented by >20 publications, several extramurally funded research projects, and licensing to a commercial entity. This nanoparticle-delivery system has intrinsic potential for modulation of its physicochemical properties, allowing use in a vast array of basic research and clinical conditions. However, the availability of these nanoparticle-delivery systems to the general urologic research community is currently limited by the absence of specific resource allocations for design and synthesis. This proposal addresses these limitations by establishing a P20 Resource Development Center with two primary goals: 1) to educate and promote the use of nanotechnology within the urologic basic and clinical research community, and 2) to create a resource development (research project) component in which the “Einstein” nanoparticle will be available for collaborative projects focused on benign urologic diseases. The proposed Resource Center will design and synthesize nanoparticles tailored to each research project until commercial entities assume this role. The Center will be highly synergistic, with investigators learning how nanotechnology can be applied to their specific field of research. Investigators will have access to resources and training, so they can apply the “Einstein” nanotechnology in their project. Investigators will require design and synthesis of novel nanoparticle formulations tailored to their specific research projects. This process would therefore lead to the development and expansion of novel nanoparticle formulations for a variety of benign urologic conditions. We anticipate that commercial entities will be positioned to synthesize nanoparticles within 2-4 years, eventually replacing the need for this P20 Resource Center.

抽象的 新型技术促进了科学发现的突破，并伴随治疗方面的进步。 就纳米技术而言，主要重点是优化其用于靶向药物输送，成像，， 诊断，或理论与诊断的结合（“治疗”）。但是，应用 良性泌尿科病理学研究和治疗中的纳米技术仍未得到充实。 在我们的机构（“爱因斯坦”），乔尔·弗里德曼（Joel Friedman）博士的研究实验室开发了纳米颗粒 - 输送系统（“爱因斯坦”纳米颗粒）。我们和其他人将该系统应用于多个研究领域， 包括20个出版物记录的良性泌尿科，包括几个基金外资助的研究项目， 并获得商业实体的许可。该纳米粒子交付系统具有调制的内在潜力 它的物理特性，允许在大量的基础研究和临床状况中使用。然而， 目前 受设计和合成的特定资源分配的限制。 该提案通过建立一个P20资源开发中心来解决这些限制 主要目标：1）在泌尿外科和临床上教育和促进纳米技术的使用 研究社区和2）创建一个资源开发（研究项目）组成部分，其中 “爱因斯坦”纳米颗粒将用于关注良性泌尿科疾病的协作项目。这 拟议的资源中心将设计和合成针对每个研究项目量身定制的纳米颗粒，直到 商业实体承担这一角色。 该中心将是高度协同的，研究人员学习如何将纳米技术应用于 他们的特定研究领域。调查人员将可以使用资源和培训，因此他们可以应用 他们的项目中的“爱因斯坦”纳米技术。研究人员将需要设计和合成新型纳米颗粒 针对其特定研究项目量身定制的公式。因此，这个过程将导致发展 以及针对各种良性泌尿科条件的新型纳米颗粒公式的扩展。我们预料到这一点 商业实体将定位在2 - 4年内合成纳米颗粒，最终取代需求 对于这个P20资源中心。