Mindfulness training with HIV-positive youth and adult family members to improve treatment adherence

对艾滋病毒呈阳性的青少年和成年家庭成员进行正念训练，以提高治疗依从性

• 批准号: 9906853
• 负责人: Julie Anne Denison
• 金额: $ 12.43万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2021-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906853
• 关键词: Accounting; Address; Adherence; Adolescent; Adolescent Behavior; Adult; Advisory Committees; African American; Age; Alcohol or Other Drugs use; Asthma; Award; Awareness; Baltimore; Behavior; Behavioral; Caring; Characteristics; Chronic Disease; Chronically Ill; Cities; Clinic; Cognitive; Committee Members; Conduct Disorder; Conflict (Psychology); Counseling; Data; Data Analyses; Development; Diabetes Mellitus; Disease; Economically Deprived Population; Educational Intervention; Environment; Family; Family Caregiver; Family Characteristics; Family member; Friends; Funding; Future; Gender; Generations; Goals; Group Meetings; HIV; HIV Infections; HIV Seropositivity; Health; Home environment; Individual; Intervention; Intervention Studies; Intervention Trial; Interview; K-Series Research Career Programs; Knowledge; Logistics; Maryland; Medical; Mental Health; Mentored Research Scientist Development Award; Mentors; Methods; Mind-Body Method; Mindfulness Training; Minority; Morbidity - disease rate; Outcome; Parents; Participant; Pathway Analysis; Peer Group; Perinatal; Pharmaceutical Preparations; Pilot Projects; Population; Process; Reading; Research; Research Methodology; Research Personnel; Research Training; Risk; Role; Schools; Scientist; Self Management; Social Environment; Social Network; Statistical Methods; Structure; Supervision; Support System; Surveys; Testing; Training; United States; United States National Institutes of Health; Universities; Viral; Well in self; Work; Yoga; Youth; adolescent health; age effect; antiretroviral therapy; base; behavior change; behavioral outcome; body-mind; career; coping; evidence base; faculty mentor; family support; follow-up; improved; intergenerational; medication compliance; mindfulness; mindfulness intervention; mindfulness meditation; mindfulness-based stress reduction; mortality; physical conditioning; public health relevance; response; satisfaction; senior faculty; skills; social; social relationships; statistics; support network; systems research; theories; therapy adherence; treatment adherence; urban underserved; virology

 DESCRIPTION (provided by applicant): The purpose of the proposed Mentored Research Scientist Career Development Award (K01) is to promote Dr. Denison's development as an independent scientist in mindfulness research with a focus on family-based mindful approaches to support HIV outcomes among adolescents living with HIV (ALHIV). ALHIV have low rates of medication adherence, increasing their risk for HIV-related morbidities and mortality. Current strategies to improve adherence, such as peer group meetings and adherence counseling, rely on educational and cognitive approaches often targeting individual behavior change without addressing the familial and social context where HIV management occurs. This career development award challenges this paradigm by examining if mindfulness offered to ALHIV and an adult family caregiver, that targets awareness of thought rather than changing the content of thought, supports the self-regulatory and medication adherence behaviors of ALHIV in Baltimore City, Maryland. The study's specific aims are to: (1) assess the family support networks among 191 participants in the parent R01. Data will characterize family support network composition and characteristics to inform family caregiver definitions and participant selection for Aims 2 and 3. (2) Examine the effects of MBSR on family support relationships and the logistics of a two-generation MBSR intervention, by conducting qualitative in-depth interviews with 20 ALHIV and 20 adult family members; and (3) examine the acceptability and feasibility of a pilot MBSR intervention among 25 ALHIV and adult family member pairs to improve adolescent adherence to ART through increased family support. The Johns Hopkins University is an ideal environment for this proposed training where the candidate will receive guidance throughout the award from Senior Faculty mentors and advisory committee members with expertise in mindfulness research and topics related to implementing mindfulness in this adolescent population, such as adolescent health, statistical methods and family-based interventions. Through a combination of directed readings, coursework, and supervised research opportunities, this mentoring team will support Dr. Denison in achieving her training goals to (1) gain expertise in mindfulness theory, interventions and research methods; (2) refine and test a two generation mindfulness-based stress reduction intervention; (3) develop statistical skills in network and dyadic data analysis; and 4) enhance knowledge of family-based interventions methods and theory. The candidate's training and research plan will provide the skills and preliminary data for Dr. Denison to pursue funding and successfully become an independent researcher in mindfulness and family-based mindful approaches to improve self-management among chronically ill adolescents.

 描述（由适用提供）：拟议的指导研究科学家职业发展奖（K01）的目的是促进丹尼森博士作为正念研究的独立科学家的发展，重点是基于家庭的正念方法来支持HIV（ALHIV）青少年的艾滋病毒成果。 ALHIV的药物依从性率较低，增加了与艾滋病毒相关的病态和死亡率的风险。当前提高依从性的策略，例如同伴小组会议和依从性咨询，依赖于教育和认知方法通常针对个人行为改变，而无需解决艾滋病毒管理的家庭和社会环境。这项职业发展奖通过检查是否给Alhiv和成年家庭护理人员提供正念而挑战了这一范式，该奖项的目标是对思想的认识而不是改变思想内容，支持Alhiv在马里兰州巴尔的摩市Alhiv的自我调节和药物依从性行为。该研究的具体目的是：（1）评估父母R01的191名参与者之间的家庭支持网络。数据将表征家庭支持网络组成和特征，以告知家庭护理人员的定义以及AIM 2和AIM的参与选择 3。（2）检查MBSR对家庭支持关系的影响以及两代MBSR干预的后勤工作，通过对20个ALHIV和20名成年家庭成员进行定性的深入访谈； （3）研究25个ALHIV和成年家庭成员成对的试点MBSR干预的可接受性和可行性，以通过增加家庭支持来提高青少年对艺术的遵守。约翰·霍普金斯大学（Johns Hopkins University）是这项拟议培训的理想环境，在该培训中，候选人将获得高级教师导师和咨询委员会成员在整个奖项中获得正念研究专家和与在这种青少年人群中实施正念相关的主题的专家，例如青少年健康，统计方法和基于家庭的干预措施。通过有定向阅读，课程工作和监督研究机会的结合，这个心理团队将支持Denison博士实现她的培训目标，以（1）获得正念理论，干预和研究方法的专业知识； （2）完善并测试两代基于正念的压力减少干预措施； （3）在网络和二元数据分析中发展统计技能； 4）增强对基于家庭的干预方法和理论的知识。候选人的培训和研究计划将为丹尼森博士提供资金的技能和初步数据，并成功成为正念和基于家庭的正念方法，以改善长期不适的青少年的自我管理。

项目成果

Youth engagement in developing an implementation science research agenda on adolescent HIV testing and care linkages in sub-Saharan Africa.

• DOI: 10.1097/qad.0000000000001509
• 发表时间: 2017-07-01
• 期刊: AIDS (London, England)
• 作者: Denison JA;Pettifor A;Mofenson LM;Kasedde S;Marcus R;Konayuma KJ;Koboto K;Ngcobo ML;Ndleleni N;Pulerwitz J;Kerrigan D
• 通讯作者: Kerrigan D