Does Reward Mediate Human Maternal Bonding? A PET-fMRI study

奖励是否能调节人类母性纽带？

• 批准号: 8633548
• 负责人: Lisa Feldman Barrett
• 金额: $ 25.73万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8633548
• 关键词: Adult; Affect; Affective; Anatomy; Applications Grants; Atrophic; Behavior; Behavior assessment; Behavioral; Binding; Biological; Biological Neural Networks; Brain; Build-it; Chemistry; Child; Child Development; Childhood; Coupling; Data; Development; Dopamine; Dopamine Receptor; Epigenetic Process; Film; Functional Magnetic Resonance Imaging; Future; Generations; Genetic Predisposition to Disease; Goals; Human; Infant; Link; Longevity; Measurement; Measures; Mediating; Medical; Methods; Modeling; Mothers; Neurobiology; Neuromodulator; Neurotransmitters; Nucleus Accumbens; Opioid; Outcome; Oxytocin; Pattern; Peptides; Performance; Personal Satisfaction; Plasma; Positron-Emission Tomography; Prevalence; Process; Psyche structure; Publications; Research; Research Methodology; Rest; Rewards; Rodent; Role; Sampling; Social Functioning; Stimulus; Structure; Ventral Striatum; Work; blood oxygenation level dependent response; brain behavior; heart rhythm; innovation; neurobiological mechanism; neurochemistry; novel; public health relevance; radioligand; receptor binding; relating to nervous system; response; social; social attachment; transmission process

DESCRIPTION (provided by applicant): The bonding between mothers and their infants have critical long term impacts on the child's physical and mental well-being across lifespan. Thus the social and biological mechanisms that support optimal bonding are critical for the child's optimal development. Prior work from our team has shown that BOLD activation in the nucleus accumbens (NAcc) is related to the level of behavioral synchronization between a mother and an infant, which is taken to be an indicator of optimal bonding. Among mothers who are synchronous with their infants, the response of the NAcc to the infant is stronger than among non-synchronous mothers, and is correlated with oxytocin plasma levels. The NAcc, along with several other key structures, belong to our recently discovered social affiliation network; strength of intrinsic connectivity within this network is linked to greater social connectedness. Synthesizing these findings, we propose an innovative model by which mother- infant synchrony leads to a oxytocin-dependent dopamine release in the NAcc and other regions of the social affiliation network. In this R21 application, we plan to use an innovative multi-disciplinary method as we begin to explore this model and measure its four components: behavioral assessments of mother-infant synchrony, which is linked to oxytocin (that will be measured in the plasma), which in turn is linked to endogenous dopamine secretion and social affiliation neural network connectivity (measured by combined fMRI-PET imaging). Together, they will allow us to assess the extent to which the anatomy, intrinsic connectivity, and functional response in this social affiliation network is linked to synchrony in a way that is mediated by dopamine and oxytocin, which are key neurotransmitters in this network. Specifically, we plan to examine if mothers with stronger connectivity in the social affiliation network are more synchronous with their infants (Aim 1). We will also evaluate whether synchronous mothers have a greater BOLD response in this network when viewing a film of their own infant for 20 minutes vs. when viewing an unfamiliar infant (Aim 2). Moreover, we will evaluate whether infant-related stimuli enhance endogenous dopamine release and whether synchronous mothers will have greater endogenous dopamine release that is correlated to oxytocin, in response to their infants. We will also explore which regions in the social affiliation network show the greatest dopamine binding (Aim 3). Understanding the neurobiological mechanisms in the mother that promote successful bonding may significantly reduce the prevalence of childhood illness and increases the child's wellbeing. Additionally, the proposed research will establish that social reward is a mechanism for human maternal affiliation, and it will begin to parse apart the neurochemistry involved in this mechanism. Last, this study plan to use a novel research methodology of combined PET and fMRI in the functional study of human behavior, and to utilize it in favor of children's development.

描述（由申请人提供）：母亲和婴儿之间的联系对孩子一生的身心健康有着至关重要的长期影响。因此，支持最佳联系的社会和生物机制对于儿童的最佳发展至关重要。我们团队之前的工作表明，伏隔核 (NAcc) 的 BOLD 激活与母亲和婴儿之间的行​​为同步水平有关，这被认为是最佳结合的指标。在与婴儿同步出生的母亲中，NAcc 对婴儿的反应比非同步母亲更强，并且与血浆催产素水平相关。 NAcc 以及其他几个关键结构都属于我们最近发现的社交关系网络；该网络内内在连通性的强度与更大的社会连通性相关。综合这些发现，我们提出了一种创新模型，通过该模型，母婴同步性导致 NAcc 和社交网络其他区域中催产素依赖性多巴胺的释放。在此 R21 应用中，我们计划使用创新的多学科方法，开始探索该模型并测量其四个组成部分：母婴同步性的行为评估，与催产素相关（将在血浆中测量） ，这反过来又与内源性多巴胺分泌和社会归属神经网络连接性（通过结合功能磁共振成像-PET 成像测量）相关。它们将使我们能够评估这个社会归属网络中的解剖结构、内在连通性和功能反应在多大程度上以多巴胺和催产素介导的同步性相关，而多巴胺和催产素是该网络中的关键神经递质。具体来说，我们计划检查在社会关系网络中具有更强连通性的母亲是否与婴儿更加同步（目标 1）。我们还将评估同步母亲在观看自己婴儿的电影 20 分钟时与观看不熟悉的婴儿时相比，在该网络中是否有更大的大胆反应（目标 2）。此外，我们将评估与婴儿相关的刺激是否会增强内源性多巴胺的释放，以及同卵母亲是否会根据婴儿的反应而释放更多与催产素相关的内源性多巴胺。我们还将探索社会归属网络中的哪些区域显示出最大的多巴胺结合（目标 3）。了解母亲促进成功联结的神经生物学机制可能会显着降低儿童疾病的患病率并增加孩子的福祉。此外，拟议的研究将确定社会奖励是人类母性归属的一种机制，并将开始解析该机制中涉及的神经化学。最后，本研究计划将PET和功能磁共振成像相结合的新研究方法用于人类行为的功能研究，并将其用于有利于儿童的发展。