Integrative Environmental Health Sciences Facility Core

综合环境健康科学设施核心

基本信息

批准号：
9904624
负责人：
Joel Daniel Kaufman
金额：
$ 36.29万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9904624
关键词：
3-Dimensional Animal Experimentation Applications Grants Basic Science Bioinformatics Biological Models Biometry Cardiac Myocytes Chronic Disease Clinical Clinical Research Collaborations Collection Consultations Core Facility Data Discipline Disease Early Diagnosis Ensure Environment Environmental Health Environmental Risk Factor Epigenetic Process Fostering Genetic Genomics Germ Cells Grant Health Policy Human Inhalation Exposure Interdisciplinary Study Kidney Liver Manuscripts Mission Modernization Molecular Organ Patients Physiological Population Research Population Study Preparation Prevention Proteomics Public Health Recording of previous events Research Research Design Research Personnel Resources Rodent Sampling Services Systems Biology Technology Testing Tissues Toxic effect Toxicology Translational Research Universities Washington Work Xenobiotics bench to bedside biobank cost effective design epidemiology study epigenomics experimental study exposed human population health practice improved innovation innovative technologies metabolomics microphysiology system novel population based research clinical testing response systems research toxicant transcriptomics translational study virtual

项目摘要

ABSTRACT The Integrative Environmental Health Sciences Facility Core (IEHSFC) serves the EDGE Center as a focal point for interdisciplinary research, the portal for accessing Center services, and a comprehensive consultation resource to assist EDGE investigators and trainees, emphasizing clinical, translational, and population-based studies. The IEHSFC allows UW EHS research to move as smoothly as possible not only from “bench-to- bedside” but also from population-based observations to bench to clinical research and onward to public health policy and practice. This facility core builds on a rich history of environmental health translational and epidemiological research at the UW. The IEHSFC facilitates EHS research bi-directionally---including translational research--and fosters the integration of basic sciences research at the University of Washington with population-based and clinical EHS research to improve early detection and prevention of environmentally related disorders. The core's mission is to provide access and consultation to EDGE Investigators to ensure that the most modern molecular and `systems biology' approaches are used to identify the interactions between genetic, epigenetic and environmental factors that contribute to the major chronic diseases. The core is comprised of three major units: the Clinical/Translational Services Unit (CTSU), the Bioinformatics and Biostatistics Unit (BBU; this unit also includes OMICs integration), and the Microphysiological Modeling of Toxicant Responses Unit (MMTRU). While the core offers a myriad of concrete services (and even a dedicated space for clinical evaluation in the CTSU), the core is first and foremost a literal and virtual collaborative space dedicated to encouraging and enabling innovative translational research and collaborations across disciplines at the UW. Figure 3.1: The IEHSFC bridges the gap across disciplines

抽象的综合环境健康科学设施核心（IEHSFC）是边缘中心作为焦点跨学科研究的观点，访问中心服务的门户网站以及全面的咨询资源以协助边缘调查人员和受训者，强调临床，转化和基于人群的资源研究。 IEHSFC允许UW EHS研究尽可能顺利地移动床头”，但也从基于人群的观察到板凳到临床研究，再到公共卫生政策和实践。该设施核心基于环境健康翻译的丰富历史和 UW的流行病学研究。 IEHSFC的最爱ehs研究双向研究---包括翻译研究 - 促进了华盛顿大学基础科学研究的整合通过基于人群和临床EHS研究，以改善对环境的早期检测和预防相关疾病。核心的使命是向调查人员提供访问和咨询确保使用最现代的分子和“系统生物学”方法来识别遗传，表观遗传学和环境因素之间的相互作用有助于主要慢性疾病。核心由三个主要单元组成：临床/转化服务部门（CTSU），生物信息学和生物统计学单元（BBU；本单元还包括OMICS集成），并且有毒反应单元（MMTRU）的微生物生理模型。而核心提供了无数的混凝土服务（甚至是CTSU中临床评估的专用空间），核心是首先是字面意思和虚拟协作空间，致力于鼓励和实现创新的翻译研究和 UW跨学科的合作。图3.1：IEHSFC桥梁跨学科的差距