Skin Biology Resource-Based Center at UCI

UCI 皮肤生物学资源中心

• 批准号: 9903217
• 负责人: Bogi Andersen
• 金额: $ 75.56万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9903217
• 关键词: Abnormal pigmentation; Area; Bioinformatics; Biological; Biology; Blood Vessels; Chemistry; Communities; Complex; Data; Data Set; Development; Diagnosis; Discipline; Disease; Engineering; Faculty; Fertilization; Fostering; Funding; Future; Genomics; Goals; Image; Imaging technology; Individual; Knowledge; Melanogenesis; Methodology; Mission; Modeling; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Pathogenesis; Process; Regenerative Medicine; Research; Research Personnel; Resources; Scheme; Science; Scientist; Skin; Skin Carcinogenesis; Systems Biology; Technology; Training; Translating; Translations; Work; analytical tool; base; cohesion; collaborative approach; epidermal stem cell; experimental study; imaging system; innovation; interdisciplinary approach; interest; knowledge translation; large scale data; mathematical methods; mathematical model; model development; molecular scale; multidisciplinary; outreach program; programs; recruit; single cell analysis; skin disorder; skin regeneration; technology development; vascular abnormality

Increasingly, advances in skin biology depend on cross-disciplinary, collaborative approaches. Through systems biology, multiple disciplines can now be integrated into a cohesive approach to skin biology. The broad, long-term objective of the UC Irvine Skin Biology Resource-based Center is to promote cross- fertilization between multiple disciplines that allows an innovative, integrated approach to regulatory mechanisms in skin biology and disease. This will be achieved through the establishment of resource cores in genomics-bioinformatics, imaging and systems biology. The interactions between investigators and cores, and between cores, will be coordinated through the Administrative Core, which will also be responsible for an enrichment program that promotes goals of the Center. The Specific Aims are: 1. To foster multidisciplinary, collaborative science between skin researchers and experts in genomics, advanced imaging, and biologically- oriented computation; and to integrate these approaches through systems biology. 2. To develop and adapt new cutting-edge technologies in genomics, imaging and biologically-oriented computation to advance skin biology research and its translation to disease. 3. To train skin researchers in advanced imaging, genomics, bioinformatics and system biology. 4. To recruit and support junior investigators in research in biology and diseases of the skin. 5. To produce and make available resources useful to the skin research community at large. The establishment of the Center will have strong impact on the well-funded, innovative research community, leading to significant discoveries relevant to regulatory mechanisms in skin biology. The Center will also draw investigators from other fields into NIAMS-funded research and promote entry of junior investigators into skin biology research.

皮肤生物学的进步越来越依赖于跨学科的协作方法。通过 系统生物学，现在可以将多个学科整合到皮肤生物学的有凝聚力的方法中。这 加州大学欧文分校皮肤生物学资源中心的广泛、长期目标是促进跨 多学科之间的融合，允许采用创新、综合的监管方法 皮肤生物学和疾病的机制。这将通过在以下领域建立资源核心来实现： 基因组学-生物信息学、成像和系统生物学。研究者和核心之间的互动，以及 核心之间的协调，将通过行政核心进行协调，该核心还负责 促进中心目标的丰富计划。具体目标是： 1. 培养多学科、 皮肤研究人员和基因组学、高级成像和生物学专家之间的合作科学 面向计算；并通过系统生物学整合这些方法。 2. 发展和适应 基因组学、成像和生物导向计算领域的新尖端技术可促进皮肤发展 生物学研究及其对疾病的转化。 3. 培训皮肤研究人员进行先进成像、基因组学、 生物信息学和系统生物学。 4. 招募和支持生物学研究的初级研究人员 皮肤疾病。 5. 生产并提供对皮肤研究界有用的资源 大的。该中心的成立将对资金充足、创新的研究产生重大影响 社区，导致与皮肤生物学调节机制相关的重大发现。该中心将 还吸引其他领域的研究人员参与 NIAMS 资助的研究，并促进初级研究人员的进入 进入皮肤生物学研究。