Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center

MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心

• 批准号: 9903475
• 负责人: TODD T BROWN
• 金额: $ 423.91万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9903475
• 关键词: Achievement; Acquired Immunodeficiency Syndrome; Affect; Age; Aging; Ancillary Study; Area; Artificial Intelligence; Baltimore; Behavior; Behavioral; Biological; Biological Specimen Banks; Cardiovascular Diseases; Cardiovascular system; Caring; Chicago; Chronic Disease; Clinic; Cohort Studies; Cryopreservation; Data; Data Coordinating Center; Diabetes Mellitus; Disease; District of Columbia; Echocardiography; Endocrine; Enrollment; Epidemic; Equilibrium; Event; Follow-Up Studies; Funding; Goals; Grant; HIV; HIV Infections; HIV antiretroviral; Health; Home environment; Hospitals; Impaired cognition; Inflammation; Laboratories; Lead; Leadership; Liver diseases; Long-Term Care; Los Angeles; Lung; Machine Learning; Malignant Neoplasms; Measurement; Medicine; Metabolic; Metabolic Diseases; Methods; National Heart, Lung, and Blood Institute; Natural History; Neurocognitive; Participant; Pathogenesis; Performance; Peripheral Blood Mononuclear Cell; Physical activity; Plasma; Play; Polysomnography; Principal Investigator; Protocols documentation; Publications; Questionnaires; RNA; Reading; Recording of previous events; Research; Research Personnel; Risk Factors; Role; Science; Site; Sleep; Specimen; T-Lymphocyte Subsets; Techniques; The Multicenter AIDS Cohort Study; Time; Viral load measurement; Walkers; Washington; Woman; Women’s Interagency HIV Study; Work; actigraphy; adjudication; antiretroviral therapy; base; career development; clinical care; clinical research site; cohort; comorbidity; data management; experience; follow-up; health disparity; high standard; improved; innovation; men; men who have sex with men; men' s group; neurocognitive disorder; psychosocial; recruit; repository; research study; response; synergism

Project Summary This application is for the renewal of the Study to Help the AIDS Research Effort (SHARE), which has been the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS) since 1984. The MACS was established with sites in Baltimore-Washington, Chicago, Pittsburgh, and Los Angeles, initially to study the natural history of HIV infection in men who have sex with men and later, with the advent of effective combination antiretroviral therapy (cART), the treated history of HIV infection, including the relationship between long-term controlled HIV infection and chronic diseases and co-morbidities associated with aging. To reflect these changing priorities in HIV research, SHARE has had subsequent enrollments to balance proportions of HIV- and HIV+ men and to reflect the HIV epidemic more accurately. Men enrolled have been followed semi annually since 1984 or enrollment and have a) provided questionnaire data, physical exam data, laboratory data (including HIV serostatus, T cell subset measurements, and HIV viral load measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells, and other specimens; and these have permitted SHARE and MACS to make major contributions to the understanding of treated and untreated HIV disease, and comorbidities associated with increased survival due to antiretroviral treatment. The present application, in response to RFA-HL-19-008, aims to extend followup of the SHARE cohort (about 640 men) from 2019 to 2026, to allow merger of SHARE (and the other MACS sites) with the nine sites of the Women’s Interagency HIV Study (WIHS) into a single cohort, termed the MACS-WIHS Combined Cohort Study (CCS), that will include both men and women. The specific aims of the CCS are outlined in a parallel application from the putative Data and Coordinating Center (DACC) of the CCS, and the 10 Specific Aims of that single cohort are outlined in the DACC application for the CCS; these include Cardiovascular (CV), Pulmonary/Sleep (PS), Neurocognitive NC), Aging (AG), Cancer, HIV Pathogenesis (PA), Psychosocial (PS), Health Disparities, Platform (PL), and Career Development (CD) Aims. The specific aims of the SHARE Clinical Research Site (CRS) are to: 1) play a leading role in the achievement 7 of these Aims by the CCS (i.e., CV, PS, AG, PA, PS, PL, and CD), including serving as a reading center for echocardiography and sleep studies; 2) to contribute to the achievement of the other 3 CCS aims, and 3) to implement all applicable CCS protocols and support the scientific goals of the CCS. Local initiatives on inflammation and physical activity will also support these aims, which take full advantage of the extensive follow-up and repository of biological specimens already available from this cohort and which will be extended under this proposal, enabling further contributions to our understanding and care of comorbidities and other health issues faced by people living with HIV today.

项目摘要 该应用程序是为了续签研究，以帮助艾滋病研究工作（共享） 自1984年以来是多中心艾滋病队列研究（MAC）的巴尔的摩 - 华盛顿DC。 由巴尔的摩 - 华盛顿，芝加哥，匹兹堡和洛杉矶的网站成立，最初是为了研究 与男人发生性关系的男性艾滋病毒感染的自然历史，随着有效组合冒险 抗逆转录病毒疗法（CART），治疗的HIV感染病史，包括长期的关系 受控的HIV感染和慢性疾病以及与衰老有关的合并症。反映这些 改变艾滋病毒研究的优先事项，Share随后入学以平衡艾滋病毒和艾滋病毒的比例 HIV+男性，以更准确地反映HIV流行。年度年度的男性已遵循 自1984年以来或注册以来，a）提供了问卷数据，体格检查数据，实验室数据（包括 HIV血清，T细胞子群测量和HIV病毒负荷测量值）以及大的存储库 血浆，血清，冷冻保存的外周血单核细胞和其他标本；这些有 允许的股份和Mac，为理解治疗和未经治疗的艾滋病毒做出重大贡献 疾病和合并症与抗逆转录病毒治疗引起的生存率增加有关。 目前的应用程序响应RFA-HL-19-008，旨在扩展股群的后续行动 （约640名男子）从2019年到2026年，以允许共同（以及其他Mac站点）与九个网站合并 妇女间艾滋病毒研究（WIHS）的单个队列中，称为Macs-wihs组合队列 研究（CCS）将包括男人和女人。 CCS的具体目的是在平行的 CCS的推定数据和协调中心（DACC）的申请以及10个具体目标 在CCS的DACC申请中概述了单个队列；其中包括心血管（CV）， 肺/睡眠（PS），神经认知NC），衰老（AG），癌症，HIV发病机理（PA），社会心理（PS）， 健康差异，平台（PL）和职业发展（CD）的目的。共享临床的具体目的 研究站点（CRS）是：1）在成就中发挥主要作用，其中包括CCS的目标（即CV，PS，， AG，PA，PS，PL和CD），包括作为超声心动图和睡眠研究的阅读中心； 2）到 有助于实现其他3 cc的目标，以及3）实施所有适用的CCS协议和 支持CCS的科学目标。有关感染和体育锻炼的当地举措也将支持 这些目标已经充分利用了广泛的生物标本的随访和存储库 可从该队列获得，并将根据该提案扩展，从而为我们的进一步贡献 了解当今艾滋病毒患者所面临的合并症和其他健康问题。