Breathing Research and Therapeutics (BREATHE)

呼吸研究和治疗（BREATHE）

• 批准号: 9901627
• 负责人: Gordon S. Mitchell
• 金额: $ 36.7万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901627
• 关键词: Breathing; Research; Therapeutic

ABSTRACT In this revised application, we propose a new pre- and post-doctoral training program at the University of Florida: Breathing REsearch And THErapeutics (BREATHE). Our proposal is to create a training program focused on the respiratory neuromuscular system, emphasizing the discovery of new knowledge and its translation to neuromuscular disorders that compromise breathing and airway defense. Diminished breathing capacity, unstable breathing and/or aspiration pneumonia from inadequate airway defense are hallmarks of many neuromuscular disorders, and respiratory failure is the most common cause of death. However, despite the fundamental importance of breathing and airway defense to the quality and duration of life in patients with degenerative neuromuscular diseases (eg. Muscular Dystrophy, Pompe Disease, ALS) or neural injury (eg. spinal cord injury), we know of no other training program with similar focus on breathing and airway defense in in these conditions. Our proposal directly addresses this critical gap in NHLBI funded research training. The ultimate goal of the BREATHE Training Program is to develop a unique cohort of researchers with strong foundations in basic research on respiratory neuromuscular biology, and a strong appreciation for the needs/realities of translational research in our attempts to develop treatments for impaired breathing and/or airway defense. Our perspective is that we can accelerate progress towards development of effective treatments for impaired breathing capacity/stability in diverse neuromuscular disorders by training investigators with: 1) a well-developed and comprehensive conceptual framework embracing similarities and differences between neuromuscular clinical disorders; and 2) a state-of-the-art “tool kit,” providing the technological know- how to perform meaningful investigations in animal models and humans with spontaneous disease. We will train individuals with diverse academic backgrounds, including neuroscience, muscle biology, engineering and/or clinical training (physicians, physical or speech therapists and veterinarians; including multiple specialties in each group). A hallmark of our program will be “cross-training,” where basic scientists are exposed to meaningful clinical experiences, and clinician scientists establish strong basic research foundations. We will capitalize on existing, and building strengths at the University of Florida to provide an integrated research-training program in respiratory neuromuscular biology and translational research. The UF Health Science Center has demonstrated its commitment to this area of research by creating a new Center for Respiratory Research and Rehabilitation. This Center, and other strengths at the UF Health Science Center, will provide an exceptional academic environment for the BREATHE Training Program.

抽象的 在此修订的申请中，我们建议在大学的大学前和博士后培训计划 佛罗里达：呼吸研究和治疗学（呼吸）。我们的建议是创建一个培训计划 专注于呼吸神经肌肉系统，强调发现新知识及其ITS的发现 转化为损害呼吸和气道防御的神经肌肉疾病。呼吸减弱 气道防御不足的容量，不稳定的呼吸和/或吸气性肺炎是 许多神经肌肉疾病和呼吸衰竭是最常见的死亡原因。但是，需求 呼吸和气道防御对患者的质量和寿命的根本重要性 退化性神经肌肉疾病（例如肌肉营养不良，庞贝病，ALS）或神经元损伤（例如 脊髓损伤），我们知道没有其他培训计划，重点是呼吸和气道防御 在这些条件下。我们的建议直接解决了NHLBI资助的研究培训中的这一关键差距。这 呼吸训练计划的最终目标是开发一个独特的研究人员 呼吸神经肌肉生物学基础研究的基础，并对 转化研究的需求/现实是我们试图开发呼吸受损和/或的治疗方法 气道防御。我们的观点是，我们可以加速进步来发展有效 通过培训研究人员的呼吸能力/稳定性的治疗 用：1）一个发达且全面的概念框架，包含相似之处和差异 在神经肌肉临床疾病之间； 2）提供技术知识的最先进的“工具套件” 如何在具有赞助疾病的动物模型和人类中进行有意义的研究。我们将 培训具有潜水员学术背景的个人，包括神经科学，肌肉生物学，工程学 和/或临床培训（医师，物理或言语治疗师和兽医；包括多个 每个组的专业）。我们计划的标志将是“交叉培训”，基础科学家在这里 暴露于有意义的临床经验，临床科学家建立了强大的基础研究 基础。我们将利用现有的现有，并在佛罗里达大学建立优势，以提供 呼吸神经肌肉生物学和转化研究中的综合研究训练计划。 UF 健康科学中心通过为这一研究领域展示了其对这一研究领域的承诺。 呼吸研究和康复。这个中心以及UF健康科学中心的其他优势， 将为呼吸训练计划提供出色的学术环境。