Diversity Supplement: Preschooler emotion regulation in the context of maternal borderline personality disorder

多样性补充：母亲边缘型人格障碍背景下学龄前儿童的情绪调节

• 批准号: 9901326
• 负责人: Maureen Zalewski
• 金额: $ 4.2万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901326
• 关键词: Attention; Biomedical Research; Borderline Personality Disorder; Child; Development; Dialectical behavior therapy; Emotions; Family; Future; Goals; Grant; Growth; Income; Interpersonal Relations; Intervention; Knowledge; Laboratories; Longevity; Measures; Mental Health; Mental disorders; Methods; Modeling; Mothers; Nursery Schools; Oregon; Outcome Measure; Pathway interactions; Pennsylvania; Process; Regulation; Research Training; Risk; Services; Socialization; Testing; Time; United States National Institutes of Health; biobehavior; emotion regulation; improved; offspring; severe mental illness; skills; skills training; suicidal behavior; tool

This diversity supplement supports R01MH111758-01A1 to promote Ana Hernandez’s research, training, and professional development. The grant regards mothers with borderline personality disorder (BPD), a serious mental illness characterized by extreme emotions, chaotic interpersonal relationships, suicidal behaviors, and a poor sense of self. Offspring of mothers with BPD are at an elevated risk for developing mental illness across the lifespan. Difficulty managing emotions are a hallmark feature of BPD, and yet the ability to do so is necessary for responding effectively to childrens’ emotions. This process is called maternal emotion socialization, which has a major impact on how children develop their own emotion regulation (ER) skills. ER develops rapidly during preschool and deficits in preschool ER are recognized as underlying future mental disorders. This proposal will test a model examining the extent to which maternal ER and emotion socialization impact child ER, which may be a significant pathway by which mental health problems are transmitted to offspring of mothers with BPD. This proposal will leverage Dialectical Behavior Therapy (DBT) Skills training, a robust and effective method for improving ER as a tool to change maternal ER in mothers with BPD. By completing multiple assessments of biobehavioral markers of child and mother ER, this study is poised to uncover a potentially modifiable pathway by which these offspring are at risk. Specifically, we will conduct a stratified RCT of DBT Skills for mothers with BPD who have preschoolers (36-48 mos). A total of 270 dyads will be collected in Eugene, Oregon and Pittsburgh Pennsylvania, with 90 pairs in each of three groups: children who have mothers with BPD who receive DBT Skills, children who have mothers with BPD who receive Family Services as Usual (FSU), and children who have non-disordered mothers, matched on income, with this final group only participating in assessments (as to quantify normative ER growth). All children will be assessed 4 times every 4-months, with the first assessment occurring prior to treatment assignment. We will use a biobehavioral laboratory battery to measure child ER, assessing emotion understanding, strategy use, attention regulation, inhibitory control, and parasympathetic regulation. In mothers, we will employ a similar multi-method approach to assess emotion acceptance, strategy use, recognition, and parasympathetic regulation. Finally, during each laboratory assessment, we will observe mother’s ability to effectively respond to children’s negative emotions. Growth curve modeling will chart child ER trajectories for all 3 groups so that we can compare child ER growth as a function of: group status (DBT Skills vs. FSU vs. income matched, non-disordered controls), changes in maternal ER, and changes in maternal emotion socialization. Findings from this proposal will identify a modifiable pathway by which offspring of mothers with BPD are at risk, determine the extent to which child ER can be restored by treating mothers, and will be the first DBT Skills trial to measure outcomes in offspring.

这种多样性补充支持 R01MH111758-01A1 来促进 Ana Hernandez 的研究， 该补助金针对患有边缘型人格障碍（BPD）的母亲， 一种严重的精神疾病，其特征是极端情绪、混乱的人际关系、自杀倾向 患有 BPD 的母亲的后代患 BPD 的风险较高。 贯穿一生的精神疾病是边缘性人格障碍的一个标志性特征。 这样做的能力对于有效地应对儿童的情绪是必要的，这个过程称为母性。 情绪社会化，对儿童如何发展自己的情绪调节（ER）有重大影响 ER 在学前阶段发展迅速，学前 ER 的缺陷被认为是潜在的未来。 该提案将测试一个模型，检查母亲 ER 和情绪的程度。 社会化影响儿童的 ER，这可能是导致心理健康问题的一个重要途径 该提案将利用辩证行为疗法（DBT）。 技能培训是改善 ER 的一种稳健有效的方法，是改变患有以下疾病的母亲的 ER 的工具 BPD。通过完成对儿童和母亲 ER 生物行为标志物的多项评估，本研究是 具体来说，我们将 对有学龄前儿童（36-48 个月）的 BPD 母亲进行 DBT 技能分层随机对照试验。 俄勒冈州尤金和宾夕法尼亚州匹兹堡将收集 270 对，其中三个地区各收集 90 对 群体：患有 BPD 的母亲接受 DBT 技能的孩子、母亲患有 BPD 的孩子 接受照常家庭服务 (FSU) 的儿童以及母亲健康状况良好的儿童，将匹配 收入，最后一组仅参与评估（以量化规范 ER 增长）。 儿童将每 4 个月接受 4 次评估，第一次评估在治疗前进行 我们将使用生物行为实验室电池来测量儿童 ER，评估情绪。 理解、策略使用、注意力调节、抑制控制和副交感调节。 母亲们，我们将采用类似的多方法来评估情绪接受度、策略使用、 最后，在每次实验室评估期间，我们都会观察。 母亲有效应对孩子负面情绪的能力将通过成长曲线模型绘制出孩子的图表。 所有 3 组的 ER 轨迹，以便我们可以将儿童 ER 增长作为以下函数进行比较： 组状态（DBT 技能与 FSU 与收入匹配、无序控制）、孕产妇 ER 的变化以及 该提案的研究结果将确定后代的可修改途径。 患有 BPD 的母亲面临风险，确定通过治疗母亲可以在多大程度上恢复儿童 ER， 这将是第一个衡量后代结果的 DBT 技能试验。