Genetic Mapping of Functional Vomeronasal Circuits
功能性犁鼻回路的基因图谱
基本信息
- 批准号:8663868
- 负责人:
- 金额:$ 33.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-01-10 至 2016-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdoptedAfferent NeuronsAggressive behaviorAnimalsBehaviorBehavioralBehavioral AssayBiological ModelsBrainCalciumCellsChemical StructureChemicalsChromosome MappingCognitive deficitsCuesDefectDetectionDiagnosticEmotionalEndocrineEndocrine systemEstrusEvolutionFamilyFemaleGeneticGenetically Engineered MouseGoalsHealthHigh Pressure Liquid ChromatographyHumanHypothalamic structureImageIndividualInstinctKnowledgeLabelLinkLogicMapsMediatingMental disordersMethodologyModalityMolecular BiologyMotivationMusNatureNeural PathwaysNeuronsNeurosecretory SystemsOutputPartner in relationshipPatternPerceptionPheromonePheromone ReceptorsPopulationPrimatesProcessProteinsPublishingReceptor GeneReproductive BehaviorReverse Transcriptase Polymerase Chain ReactionRitual compulsionSensorySensory ProcessSex AttractantsSex DiscriminationSexual MaturationSignal TransductionStereotypingStimulusSystemTestingTherapeuticTransgenic AnimalsTransgenic MiceUrineVertebratesVomeronasal SystemsWell in selfbasecalcium indicatorexperienceinformation processinginnovationinsightliquid chromatography mass spectrometrymaleneural circuitneuromechanismnovelnovel strategiesreceptorresearch studyresponsesensorsensory mechanismsensory systemsexsocialsocial communicationvomeronasal organ
项目摘要
DESCRIPTION (provided by applicant): The proper functioning of the sensory and endocrine systems is essential for the health and well being of human beings. Sensory experiences often have direct influence on endocrine systems and many experience- induced endocrine responses are innate. However, the neural circuitry that controls these processes is not well understood. In the proposed project, we will study the mouse vomeronasal circuitry as a model system to elucidate the neural mechanism of sensory information processing and mechanism of sensory control of endocrine function. In vertebrates, innate behaviors such as mating rituals and territorial aggression are elicited by the detection of pheromone cues through the vomeronasal organ. These behaviors are robust and stereotyped, but their expression critically depends on the proper response to pheromones. The vomeronasal circuit connects directly to the endocrine systems and influences their output. These circuits are largely genetically determined and there is an intrinsic link between sensory input and the behavior and endocrine responses, making it an attractive and tractable circuitry to understand sensory processing and sensory control of endocrine changes. The objective of this application is to identify the sex pheromones, their receptors and trace the neural circuitry processing the information. We hypothesize that male and female pheromones elicit responses from distinct populations of cells in the VNO. This information is represented in the brain by the distinct spatial patterns of the sensory neuron projection and allows sex discrimination and differential endocrine changes in response. In Aim 1, we will use transgenic animals expressing calcium indicators in the sensory neurons to identify cells that respond to specific pheromones in urine. Combining fluorescent imaging, mouse genetics and molecular biology, we will identify the pheromone receptor gene expressed by these cells. We will screen urine fractions to chemically identify the pheromones. In Aim 2, we will trace the information flow by genetically labeling the neurons expressing the sex pheromone receptors. In Aim 3, we will combine genetic experiments with behavioral assays to analyze pheromone control of endocrine responses. Animals have evolved specialized neural circuitry that links sensory input to endocrine responses. The complexity of sensory experiences makes it difficult to study sensory control of endocrine response in humans. The vomeronasal system is highly evolved in most vertebrate species and is specialized in controlling endocrine system and emotional states. Similar circuits exist in humans but may have been compacted during primate evolution to consist of mostly the main olfactory, and to include other sensory modalities. Insight gained from this study will help to elucidate control mechanism of endocrine systems and motivational states, as well as the processing of social communication.
描述(由申请人提供):感觉和内分泌系统的正常运作对于人类的健康和福祉至关重要。感官体验通常对内分泌系统有直接影响,并且许多体验引起的内分泌反应是与生俱来的。然而,控制这些过程的神经回路尚不清楚。在本项目中,我们将研究小鼠犁鼻环路作为模型系统,以阐明感觉信息处理的神经机制和内分泌功能的感觉控制机制。在脊椎动物中,诸如交配仪式和领土攻击等先天行为是通过犁鼻器官检测到信息素线索而引发的。这些行为是鲁棒且刻板的,但它们的表达很大程度上取决于对信息素的正确反应。犁鼻回路直接连接到内分泌系统并影响其输出。这些回路很大程度上是由基因决定的,感觉输入与行为和内分泌反应之间存在内在联系,使其成为了解感觉处理和内分泌变化的感觉控制的有吸引力且易于处理的回路。 该应用程序的目的是识别性信息素及其受体并追踪处理信息的神经回路。我们假设雄性和雌性信息素会引起 VNO 中不同细胞群的反应。这些信息在大脑中通过感觉神经元投射的不同空间模式来表示,并允许性别歧视和不同的内分泌变化做出反应。在目标 1 中,我们将使用在感觉神经元中表达钙指示剂的转基因动物来识别对尿液中特定信息素做出反应的细胞。结合荧光成像、小鼠遗传学和分子生物学,我们将鉴定这些细胞表达的信息素受体基因。我们将筛选尿液成分,以化学方式识别信息素。在目标 2 中,我们将通过基因标记表达性信息素受体的神经元来追踪信息流。在目标 3 中,我们将把基因实验与行为分析结合起来,分析信息素对内分泌反应的控制。 动物已经进化出专门的神经回路,将感觉输入与内分泌反应联系起来。感官体验的复杂性使得研究人类内分泌反应的感官控制变得困难。大多数脊椎动物的犁鼻系统都高度进化,专门控制内分泌系统和情绪状态。人类也存在类似的回路,但在灵长类动物的进化过程中可能已经被压缩,主要由主要嗅觉组成,并包括其他感觉方式。从这项研究中获得的见解将有助于阐明内分泌系统和动机状态的控制机制,以及社会沟通的处理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Congrong Ron Yu', 18)}}的其他基金
Circuit Mechanism of Pheromone Processing and Innate Behavior
信息素加工和先天行为的回路机制
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Mechanisms of Developmental Plasticity in the Mammalian Olfactory System
哺乳动物嗅觉系统发育可塑性机制
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10174905 - 财政年份:2018
- 资助金额:
$ 33.79万 - 项目类别:
Mechanisms of Developmental Plasticity in the Mammalian Olfactory System
哺乳动物嗅觉系统发育可塑性机制
- 批准号:
10119618 - 财政年份:2018
- 资助金额:
$ 33.79万 - 项目类别:
Mechanisms of Developmental Plasticity in the Mammalian Olfactory System
哺乳动物嗅觉系统发育可塑性机制
- 批准号:
10424507 - 财政年份:2018
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$ 33.79万 - 项目类别:
Genetic Mapping of Functional Vomeronasal Circuit
功能性犁鼻环路的基因图谱
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Genetic Mapping of Functional Vomeronasal Circuit
功能性犁鼻环路的基因图谱
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7850288 - 财政年份:2009
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Genetic Mapping of Functional Vomeronasal Circuits
功能性犁鼻回路的基因图谱
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8278484 - 财政年份:2006
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$ 33.79万 - 项目类别:
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