Videogame-based environmental enrichment training for altercations in hippocampal function and memory in middle-aged adults

基于视频游戏的环境丰富训练对中年人海马功能和记忆力的影响

• 批准号: 9532048
• 负责人: Craig E Stark
• 金额: $ 19.31万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9532048
• 关键词: Adult; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Anger; Animals; Behavior Therapy; Behavioral; Birds; Brain; Brain Injuries; Cognition; Cognitive; Cognitive aging; Cognitive deficits; Complex; Computer Simulation; Data; Dementia; Diffusion; Disease; Education; Effectiveness; Environment; Environment Design; Exhibits; Exposure to; General Population; Generations; Hippocampus (Brain); Human; Image; Individual; Individual Differences; Intervention; Lead; Learning; Life Style; Literature; Longevity; Memory; Memory Loss; Memory impairment; Mental Depression; Neurodegenerative Disorders; Neuronal Plasticity; Participant; Performance; Play; Population; Prevention; Problem Solving; Process; Publishing; Reaction Time; Rehabilitation therapy; Resolution; Rodent; Rodent Model; Scanning; Sensory; Shapes; Sleep; Stress; Structure; Study models; Synapses; Techniques; Technology; Testing; Training; Video Games; age effect; age group; age related; aged; base; behavior influence; cognitive benefits; combat; design; environmental enrichment for laboratory animals; experience; healthy aging; human old age (65+); improved; lifestyle intervention; middle age; nervous system disorder; neurogenesis; newborn neuron; relating to nervous system; skills; social; synaptogenesis; virtual reality; young adult; Adult; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Anger; Animals; Behavior Therapy; Behavioral; Birds; Brain; Brain Injuries; Cognition; Cognitive; Cognitive aging; Cognitive deficits; Complex; Computer Simulation; Data; Dementia; Diffusion; Disease; Education; Effectiveness; Environment; Environment Design; Exhibits; Exposure to; General Population; Generations; Hippocampus (Brain); Human; Image; Individual; Individual Differences; Intervention; Lead; Learning; Life Style; Literature; Longevity; Memory; Memory Loss; Memory impairment; Mental Depression; Neurodegenerative Disorders; Neuronal Plasticity; Participant; Performance; Play; Population; Prevention; Problem Solving; Process; Publishing; Reaction Time; Rehabilitation therapy; Resolution; Rodent; Rodent Model; Scanning; Sensory; Shapes; Sleep; Stress; Structure; Study models; Synapses; Techniques; Technology; Testing; Training; Video Games; age effect; age group; age related; aged; base; behavior influence; cognitive benefits; combat; design; environmental enrichment for laboratory animals; experience; healthy aging; human old age (65+); improved; lifestyle intervention; middle age; nervous system disorder; neurogenesis; newborn neuron; relating to nervous system; skills; social; synaptogenesis; virtual reality; young adult

Project Summary The positive effects of environmental enrichment and their neural bases have been extensively studied in the rodent. For example, simply modifying an animal’s living environment to promote sensory stimulation can lead to enhancements in hippocampal cognition and neuroplasticity as well as to improve memory deficits associated with neurodegenerative diseases such as Alzheimer’s Disease and aging. While many studies of human aging have focused on individuals aged 65 and older, there are many aspects of cognition (including memory), which show a decline across the lifespan. In addition, current strategies for combating Alzheimer’s Disease are focused heavily on early prevention. Thus, the age group of 40-49 years old represents an understudied age group, which may benefit from a cognitive intervention aimed at improving memory performance. In this proposal, we hypothesize that the exploration of the vast and visually stimulating virtual environments within video games, is a human correlate of environmental enrichment. Although humans, in many ways, already live in an enriched environment, we are constantly adapting to new experiences and situations within our own environment on a daily basis. Video game training may provide a conduit for optimizing the cognitive and neural benefits of environmental enrichment for use as a behavioral intervention for improving memory performance, and possibly, hippocampal function. Recent published data from our lab has already provided evidence that memory performance on unrelated hippocampal-dependent tasks is improved following a 2-week training period on a 3D video game in young adults. In contrast, training on a 2D video game did not result in a boost in memory performance. Here, we seek to explore the neural contributions to this training by evaluating hippocampal structure and function in a pre/post design in adults, aged 40-49 years old. Further, we seek to determine the key features of such an intervention paradigm to explore the key features of video games (the spatial aspect, the complexity of the game, or some combination) to evaluate the potential benefit of environmental enrichment training. These data provide a bridge to much of the rodent literature exploring the benefits of environmental enrichment, extending these principles into humans. Most of the cognitive intervention paradigms currently studied or in use provide a benefit for the precise skill being trained (e.g. improved reaction time over the course of many trials), but they do not generalize to other tasks or cognitive domains. Our preliminary data suggests that following 3D video game training, performance on unrelated, hippocampal-dependent tasks is improved, which is extremely rare and offers great potential as a rehabilitation technique. By focusing on an age group that is fluent with technology, but beginning to exhibit subtle signs of age-related cognitive decline, we can explore the neural and cognitive benefits of such training. The benefits of such training have the potential to be applied to rehabilitation following brain injury and neurological disease, education, and possibly even the benefit of the general population.

项目摘要 环境富集及其神经碱的积极影响已广泛研究 啮齿动物。例如，仅修改动物的生活环境以促进感觉刺激 增强海马认知和神经可塑性，并改善记忆力不足 与阿尔茨海默氏病和衰老等神经退行性疾病有关。而许多研究 人类的衰老专注于65岁及以上的个体，认知有许多方面（包括 记忆），显示整个生命周期的下降。此外，目前与阿尔茨海默氏症的战略 疾病主要集中在早期预防上。那是40-49岁的年龄段代表 研究年龄段，这可能会受益于旨在改善记忆的认知干预措施 表现。在此提案中，我们假设探索广阔的和视觉刺激的虚拟 视频游戏中的环境是环境丰富的人类相关性。虽然人类，在 许多方式已经生活在丰富的环境中，我们一直在适应新的体验， 每天在我们自己的环境中的情况。视频游戏训练可能会为 优化环境丰富的认知和神经益处作为行为干预 用于改善记忆性能和可能的海马功能。我们实验室的最新发布数据 已经提供了证据，表明无关海马依赖性任务上的记忆性能是 经过2周的培训期，在年轻人的3D视频游戏中进行了2周的培训。相反，对2D进行培训 视频游戏不会导致内存性能的提高。在这里，我们试图探索神经贡献 通过评估40-49岁的成年人的前/后设计中的海马结构和功能来培训。 年龄。此外，我们试图确定这种干预范式的关键特征，以探索钥匙 视频游戏的功能（空间方面，游戏的复杂性或某种组合）来评估 环境丰富训练的潜在好处。这些数据为大部分啮齿动物提供了桥梁 文献探讨了环境丰富的好处，将这些原则扩展到人类。大多数 当前研究或使用的认知干预范例为精确技能提供了好处 经过培训（例如，在许多试验过程中的反应时间有所改善），但它们不会推广到其他任务或 认知领域。我们的初步数据表明，经过3D视频游戏训练，性能 无关，海马依赖性任务得到了改进，这是极为罕见的，并且具有巨大的潜力 康复技术。通过专注于流利技术但开始退出的年龄段 与年龄相关的认知能力下降的微妙迹象，我们可以探索这种训练的神经和认知益处。 这种训练的好处有可能应用于脑损伤后的康复 神经疾病，教育，甚至可能的受益。