Brown/Moi Training Program for the Prevention of HIV related Cervical Cancer

Brown/Moi 预防艾滋病毒相关宫颈癌培训计划

• 批准号: 9769364
• 负责人: SUSAN CU-UVIN
• 金额: $ 30.48万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-16 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769364
• 关键词: AIDS prevention; Adult; Age; Area; Behavior assessment; Caring; Cervical; Cervical Cancer Screening; Cervix Neoplasms; Cessation of life; Country; Data; Educational workshop; Ethical Issues; Goals; HIV; HIV Infections; Health; Human Papilloma Virus Vaccination; Human Papillomavirus; Human papilloma virus infection; Incidence; Interdisciplinary Study; Kenya; Laboratory Technicians; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Nurses; Pathogenesis; Pharmacists; Prevention; Research; Research Assistant; Research Personnel; Research Training; Social Workers; Standardization; Technology; Training; Training Programs; Translational Research; United States National Institutes of Health; Woman; antiretroviral therapy; cancer vaccination; cost; improved; low and middle-income countries; men; multidisciplinary; programs; screening; screening program; social; symposium

Every year, cervical cancer is responsible for 275,000 deaths worldwide, of which about 88% occurred in lower and middle income countries where HIV infection is greatest and access to skilled care is poorest. The adult HIV incidence rate in Kenya is 1.21/1000 in 2017. There are 1,500,000 Kenyans living with HIV: 860,000 are women compared to 520,000 men. Cervical cancer is the most common gynecological cancer in this country . The crude incidence of cervical cancer in Kenya is 22.4/100,000 women and the age standardized rate (15-44 y.o.) is 40.1/100,000. Cervical neoplasia/cancer is more prevalent among women living with HIV (WLHIV) . As WLHIV are living longer with increasing access to combination antiretroviral therapy and if we are to optimally improve their health and lives, it is not enough to provide HIV treatment through many programs including PEPFAR programs and watch them die from cervical cancer. The focus of this proposed research training program is the understanding of the pathogenesis of cervical cancer in WLHIV and to optimize the screening, prevention and treatment of HIV related cervical cancer. A multidisciplinary group of Kenyan researchers will be trained to conduct HIV, HPV, cervical cancer related studies with the end goal of decreasing cervical cancer related deaths among WLHIV. The scope of training will be related to priority areas identified by the Kenyan MOH:1) translational research on the interactions between HIV and HPV; 2) improvement of cervical cancer screening programs including low cost technologies ;3) assessment of the best treatment options for cervical precancer/cancer among WLHIV ;4) operational studies on HPV vaccination and 5) assessment of behavioral, social and ethical issues related to HPV infection, cervical precancer/cancer, and HPV vaccination. We propose to train 6 long term trainees in graduate studies (2PhD and 4 Master’s ); 8 medium term trainees (3-6 months) for doctors, nurses, cytotechnologists, data managers, pharmacist, social workers, research assistants, laboratory technicians; and conduct short term symposiums/workshops in these priority areas. The ultimate goal is to develop a cadre of multidisciplinary researches in Western Kenya who will anchor research in this NIH priority area and to increase research capacity on HIV and cervical cancer in Kenya.

每年，宫颈癌在全球造成275,000人死亡，其中约88％ 发生在最大的艾滋病毒感染最大的中低收入国家中 熟练的护理最贫穷。肯尼亚的成人艾滋病毒发病率在2017年为1.21/1000。 1,500,000肯尼亚人患有艾滋病毒的肯尼亚人：女性为860,000，而520,000名男性则是女性。宫颈 癌症是该国最常见的妇科癌症。原始事件的 肯尼亚的宫颈癌为22.4/100,000妇女，年龄标准化率（15-44 Y.O.）为 40.1/100,000。宫颈肿瘤/癌症在艾滋病毒的女性中更为普遍 （wlhiv）。随着WLHIV的寿命更长 治疗，如果我们要最佳地改善他们的健康和生活，这还不足以提供艾滋病毒 通过包括PEPFAR计划在内的许多程序进行治疗，看着它们死于 宫颈癌。该建议的研究培训计划的重点是对 WLHIV中宫颈癌的发病机理，并优化筛查，预防和 治疗HIV相关的宫颈癌。肯尼亚研究人员将是一个多学科的小组 受过培训以进行HIV，HPV，宫颈癌相关研究，以减少的最终目标 WLHIV之间的宫颈癌相关死亡。培训范围将与优先级有关 肯尼亚MOH确定的领域：1）关于HIV之间相互作用的转化研究 和HPV; 2）改进宫颈癌筛查计划，包括低成本 技术； 3）评估宫颈预科/癌症的最佳治疗方案 WLHIV; 4）有关HPV疫苗接种的运营研究和5）评估行为，社会和 与HPV感染，宫颈预科/癌症和HPV疫苗接种有关的道德问题。我们 提议培训6名长期学员的研究生学习（2PHD和4个硕士）； 8个媒介 学期学员（3-6个月），用于医生，护士，细胞技术医生，数据经理，药剂师， 社会工作者，研究助理，实验室技术人员；并进行短期 这些优先领域的研讨会/研讨会。最终目标是建立一个干部 肯尼亚西部的多学科研究将在此NIH优先领域锚定研究 并增加肯尼亚艾滋病毒和宫颈癌的研究能力。